产品简要
公司名称 :
圣克鲁斯生物技术
产品类型 :
抗体
产品名称 :
细胞周期蛋白D1(DCS-6)抗体
目录 :
sc-20044
规格 :
200微克/毫升
价格 :
279美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
DCS-6
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 77
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 6d
Guiley K, Stevenson J, Lou K, Barkovich K, Kumarasamy V, Wijeratne T, et al. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019;366: pubmed 出版商
  • 免疫印迹; 小鼠; 图 3d
Lee Y, Yeo I, Kim K, Han S, Hong J. Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity. Front Immunol. 2019;10:1379 pubmed 出版商
  • 免疫沉淀; 人类; 图 4b
  • 免疫细胞化学; 人类; 图 4c
  • 免疫印迹; 人类; 图 4b
He D, Ren B, Liu S, Tan L, Cieply K, Tseng G, et al. Oncogenic activity of amplified miniature chromosome maintenance 8 in human malignancies. Oncogene. 2017;36:3629-3639 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2b
Tormos A, Rius Pérez S, Jorques M, Rada P, Ramírez L, Valverde A, et al. p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. PLoS ONE. 2017;12:e0171738 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
  • 免疫印迹; 小鼠; 1:1000; 图 s1
Chen P, Qin L, Li G, Tellides G, Simons M. Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGF?)-dependent smooth muscle cell phenotype modulation. Sci Rep. 2016;6:33407 pubmed 出版商
  • 免疫印迹; 人类; 1:3000; 图 5a
Gao S, Yang X, Wang M. Inhibitory effects of B?cell translocation gene 2 on skin cancer cells via the Wnt/??catenin signaling pathway. Mol Med Rep. 2016;14:3464-8 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Li C, Li Q, Cai Y, He Y, Lan X, Wang W, et al. Overexpression of angiopoietin 2 promotes the formation of oral squamous cell carcinoma by increasing epithelial-mesenchymal transition-induced angiogenesis. Cancer Gene Ther. 2016;23:295-302 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s1
Gvozdenović A, Boro A, Meier D, Bode Lesniewska B, Born W, Muff R, et al. Targeting αvβ3 and αvβ5 integrins inhibits pulmonary metastasis in an intratibial xenograft osteosarcoma mouse model. Oncotarget. 2016;7:55141-55154 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s1
Chen P, Qin L, Li G, Tellides G, Simons M. Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression. EMBO Mol Med. 2016;8:712-28 pubmed 出版商
  • 免疫印迹; 人类; 表 1
Lombardo G, Dentelli P, Togliatto G, Rosso A, Gili M, Gallo S, et al. Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action. Sci Rep. 2016;6:25689 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Xiao L, Shi X, Zhang Y, Zhu Y, Zhu L, Tian W, et al. YAP induces cisplatin resistance through activation of autophagy in human ovarian carcinoma cells. Onco Targets Ther. 2016;9:1105-14 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 5
Ercilla A, Llopis A, Feu S, Aranda S, Ernfors P, Freire R, et al. New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress. Nucleic Acids Res. 2016;44:4745-62 pubmed 出版商
  • 免疫组化; 大鼠; 1:50; 图 5c
Ge S, Zhang J, Du Y, Hu B, Zhou Z, Lou J. Dynamic changes in the gene expression profile during rat oral carcinogenesis induced by 4-nitroquinoline 1-oxide. Mol Med Rep. 2016;13:2561-9 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Podmirseg S, Jäkel H, Ranches G, Kullmann M, Sohm B, Villunger A, et al. Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion. Oncogene. 2016;35:4580-90 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s3
Lauková J, Kozubík A, Hofmanová J, Nekvindová J, Sova P, Moyer M, et al. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PLoS ONE. 2015;10:e0141020 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7
Sakabe I, Hu R, Jin L, Clarke R, Kasid U. TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling. Breast Cancer Res Treat. 2015;153:285-97 pubmed 出版商
  • 流式细胞仪; 人类; 图 6
Sarojini S, Pecora A, Milinovikj N, Barbiere J, Gupta S, Hussain Z, et al. A combination of high dose rate (10X FFF/2400 MU/min/10 MV X-rays) and total low dose (0.5 Gy) induces a higher rate of apoptosis in melanoma cells in vitro and superior preservation of normal melanocytes. Melanoma Res. 2015;25:376-89 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Han Y, Lee J, Lee S. Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of rapamycin pathways. Mol Med Rep. 2015;12:3446-3452 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Zhang W, Hou J, Wang X, Jiang R, Yin Y, Ji J, et al. PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis. Oncotarget. 2015;6:9420-33 pubmed
  • 免疫印迹; 小鼠; 1:800; 图 5
Dubon M, Park K. Substance P enhances the proliferation and migration potential of murine bone marrow-derived mesenchymal stem cell-like cell lines. Exp Ther Med. 2015;9:1185-1191 pubmed
  • 免疫印迹; 人类; 1:1500
Wang G, Liu G, Ye Y, Fu Y, Zhang X. The role of microRNA-1274a in the tumorigenesis of gastric cancer: accelerating cancer cell proliferation and migration via directly targeting FOXO4. Biochem Biophys Res Commun. 2015;459:629-35 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
Sun X, Tang S, Xu C, Wang C, Qin S, Du N, et al. DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1. J Cell Mol Med. 2015;19:1357-65 pubmed 出版商
  • 免疫印迹; 人类; 1:300
Mishra R, Nagini S, Rana A. Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression. Mol Cancer. 2015;14:20 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Bele A, Mirza S, Zhang Y, Ahmad Mir R, Lin S, Kim J, et al. The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells. Cell Cycle. 2015;14:990-1000 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Zhao H, Xie C, Lin X, Zhao Y, Han Y, Fan C, et al. Coexpression of IQ-domain GTPase-activating protein 1 (IQGAP1) and Dishevelled (Dvl) is correlated with poor prognosis in non-small cell lung cancer. PLoS ONE. 2014;9:e113713 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Fan C, Jiang G, Zhang X, Miao Y, Lin X, Luan L, et al. Zbed3 contributes to malignant phenotype of lung cancer via regulating β-catenin and P120-catenin 1. Mol Carcinog. 2015;54 Suppl 1:E138-47 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Tian L, Wang C, Hagen F, Gormley M, Addya S, Soccio R, et al. Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells. Oncotarget. 2014;5:7303-15 pubmed
  • 免疫印迹; 人类
Oliveira C, de Bock C, Molloy T, Sadeqzadeh E, Geng X, Hersey P, et al. Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma. BMC Cancer. 2014;14:630 pubmed 出版商
  • 免疫组化; 小鼠
Costales M, Lopez F, García Inclán C, Fernandez S, Marcos C, Llorente J, et al. Establishment and characterization of an orthotopic sinonasal squamous cell carcinoma mouse model. Head Neck. 2015;37:1769-75 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Velicky P, Haider S, Otti G, Fiala C, Pollheimer J, Knöfler M. Notch-dependent RBPJ? inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts. Mol Hum Reprod. 2014;20:756-66 pubmed 出版商
  • 免疫印迹; 人类
Wu K, Chen K, Wang C, Jiao X, Wang L, Zhou J, et al. Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation. Cancer Res. 2014;74:829-39 pubmed 出版商
  • 免疫印迹; 小鼠
Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, et al. PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-?B. J Hepatol. 2014;60:306-12 pubmed 出版商
  • 免疫印迹; 人类
Shan L, Li X, Liu L, Ding X, Wang Q, Zheng Y, et al. GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporation. Oncogene. 2014;33:3205-16 pubmed 出版商
  • 免疫印迹; 人类
Hsu F, Yang M, Lin E, Tseng C, Lin H. The significance of Her2 on androgen receptor protein stability in the transition of androgen requirement in prostate cancer cells. Am J Physiol Endocrinol Metab. 2011;300:E902-8 pubmed 出版商
McLaughlin R, He J, van der Noord V, Redel J, Foekens J, Martens J, et al. A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy. Breast Cancer Res. 2019;21:77 pubmed 出版商
Knudsen E, Kumarasamy V, Ruiz A, Sivinski J, Chung S, Grant A, et al. Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer. Oncogene. 2019;38:3355-3370 pubmed 出版商
Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough M, Dhir S, et al. Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease. elife. 2018;7: pubmed 出版商
Ruiz Estévez M, Staats J, Paatela E, Munson D, Katoku Kikyo N, Yuan C, et al. Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization. Cell Rep. 2018;25:2537-2551.e8 pubmed 出版商
Baek H, Kim S, Choi E, Kim J, Shin D, Park E, et al. Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation. Int J Biol Sci. 2018;14:1755-1768 pubmed 出版商
Inoue M, Uchida Y, Edagawa M, Hirata M, Mitamura J, Miyamoto D, et al. The stress response gene ATF3 is a direct target of the Wnt/β-catenin pathway and inhibits the invasion and migration of HCT116 human colorectal cancer cells. PLoS ONE. 2018;13:e0194160 pubmed 出版商
Chen H, Xu X, Wang G, Zhang B, Wang G, Xin G, et al. CDK4 protein is degraded by anaphase-promoting complex/cyclosome in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells. J Biol Chem. 2017;292:10131-10141 pubmed 出版商
Chu Q, Han N, Yuan X, Nie X, Wu H, Chen Y, et al. DACH1 inhibits cyclin D1 expression, cellular proliferation and tumor growth of renal cancer cells. J Hematol Oncol. 2014;7:73 pubmed 出版商
Tengku Ahmad T, Jaafar F, Jubri Z, Abdul Rahim K, Rajab N, Makpol S. Gelam honey attenuated radiation-induced cell death in human diploid fibroblasts by promoting cell cycle progression and inhibiting apoptosis. BMC Complement Altern Med. 2014;14:108 pubmed 出版商
Yu Z, Wang L, Wang C, Ju X, Wang M, Chen K, et al. Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. Nat Commun. 2013;4:2812 pubmed 出版商
Huang P, Huang C, Chen M, Lee Y, Yue C, Wang H, et al. Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER ? Inhibition. Evid Based Complement Alternat Med. 2013;2013:376123 pubmed 出版商
Li F, Yu X, Szynkarski C, Meng C, Zhou B, Barhoumi R, et al. Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation. PLoS ONE. 2013;8:e64771 pubmed 出版商
Storbeck C, Al Zahrani K, Sriram R, Kawesa S, O Reilly P, Daniel K, et al. Distinct roles for Ste20-like kinase SLK in muscle function and regeneration. Skelet Muscle. 2013;3:16 pubmed 出版商
Molitor T, Traktman P. Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo. Oncogenesis. 2013;2:e48 pubmed 出版商
de Sousa E, Walter L, Higa G, Casado O, Kihara A. Developmental and functional expression of miRNA-stability related genes in the nervous system. PLoS ONE. 2013;8:e56908 pubmed 出版商
Yan G, Eller M, Elm C, Larocca C, Ryu B, Panova I, et al. Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells. J Invest Dermatol. 2013;133:2444-2452 pubmed 出版商
Wu K, Li Z, Cai S, Tian L, Chen K, Wang J, et al. EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1. Cancer Res. 2013;73:4488-99 pubmed 出版商
McCarthy B, Yang L, Ding J, Ren M, King W, Elsalanty M, et al. NF-?B2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors. BMC Cancer. 2012;12:203 pubmed 出版商
Pérez Luna M, Aguasca M, Perearnau A, Serratosa J, Martínez Balbás M, Jesús Pujol M, et al. PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27 Kip1. Nucleic Acids Res. 2012;40:6520-33 pubmed 出版商
Almeida M, Nicoloso M, Zeng L, Ivan C, Spizzo R, Gafa R, et al. Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. Gastroenterology. 2012;142:886-896.e9 pubmed 出版商
Boulay G, Malaquin N, Loison I, Foveau B, Van Rechem C, Rood B, et al. Loss of Hypermethylated in Cancer 1 (HIC1) in breast cancer cells contributes to stress-induced migration and invasion through ?-2 adrenergic receptor (ADRB2) misregulation. J Biol Chem. 2012;287:5379-89 pubmed 出版商
Li L, Ying J, Li H, Zhang Y, Shu X, Fan Y, et al. The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/?-catenin signaling and silenced in common carcinomas. Oncogene. 2012;31:3901-12 pubmed 出版商
Ferreira A, Suriano G, Mendes N, Gomes B, Wen X, Carneiro F, et al. E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2. Hum Mol Genet. 2012;21:334-43 pubmed 出版商
Rodrigo J, Alvarez Alija G, Menéndez S, Mancebo G, Allonca E, Garcia Carracedo D, et al. Cortactin and focal adhesion kinase as predictors of cancer risk in patients with laryngeal premalignancy. Cancer Prev Res (Phila). 2011;4:1333-41 pubmed 出版商
Zhang X, Strakovsky R, Zhou D, Zhang Y, Pan Y. A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats. J Nutr. 2011;141:1254-9 pubmed 出版商
Majumdar A, Ghosh A, Datta S, Prudner B, Datta B. p67/MetAP2 suppresses K-RasV12-mediated transformation of NIH3T3 mouse fibroblasts in culture and in athymic mice. Biochemistry. 2010;49:10146-57 pubmed 出版商
Cubas R, Zhang S, Li M, Chen C, Yao Q. Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer. 2010;9:253 pubmed 出版商
Chen Y, Yu G, Yu D, Zhu M. PKCalpha-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-beta1. J Exp Clin Cancer Res. 2010;29:104 pubmed 出版商
Noel E, Yeste Velasco M, Mao X, Perry J, Kudahetti S, Li N, et al. The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers. Am J Pathol. 2010;176:2607-15 pubmed 出版商
Lim Y, Kwon J, Kim D, Lee S, Park R, Lee J, et al. Obovatol from Magnolia obovata inhibits vascular smooth muscle cell proliferation and intimal hyperplasia by inducing p21Cip1. Atherosclerosis. 2010;210:372-80 pubmed 出版商
Kim J, Gurumurthy C, Naramura M, Zhang Y, Dudley A, Doglio L, et al. Role of mammalian Ecdysoneless in cell cycle regulation. J Biol Chem. 2009;284:26402-10 pubmed 出版商
Ahmed K, Fan M, Nantajit D, Cao N, Li J. Cyclin D1 in low-dose radiation-induced adaptive resistance. Oncogene. 2008;27:6738-48 pubmed 出版商
Farnebo L, Jerhammar F, Vainikka L, Grenman R, Norberg Spaak L, Roberg K. Number of negative points: a novel method for predicting radiosensitivity in head and neck tumor cell lines. Oncol Rep. 2008;20:453-61 pubmed
Burton D, Sheerin A, Ostler E, Smith K, Giles P, Lowe J, et al. Cyclin D1 overexpression permits the reproducible detection of senescent human vascular smooth muscle cells. Ann N Y Acad Sci. 2007;1119:20-31 pubmed
Cai Q, McReynolds M, Keck M, Greer K, Hoying J, Brooks H. Vasopressin receptor subtype 2 activation increases cell proliferation in the renal medulla of AQP1 null mice. Am J Physiol Renal Physiol. 2007;293:F1858-64 pubmed
Ou Y, Chung P, Hsu F, Sun T, Chang W, Shieh S. The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1. EMBO J. 2007;26:3968-80 pubmed
Lillehoj E, Lu W, Kiser T, Goldblum S, Kim K. MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism. Biochim Biophys Acta. 2007;1773:1028-38 pubmed
He G, Kuang J, Huang Z, Koomen J, Kobayashi R, Khokhar A, et al. Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21. Br J Cancer. 2006;95:1514-24 pubmed
Ranjan P, Anathy V, Burch P, Weirather K, Lambeth J, Heintz N. Redox-dependent expression of cyclin D1 and cell proliferation by Nox1 in mouse lung epithelial cells. Antioxid Redox Signal. 2006;8:1447-59 pubmed
Yao S, Zhang Y, Li J. c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent. Mol Carcinog. 2006;45:605-12 pubmed
O Regan R, Osipo C, Ariazi E, Lee E, Meeke K, Morris C, et al. Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice. Clin Cancer Res. 2006;12:2255-63 pubmed
Clappier E, Cuccuini W, Cayuela J, Vecchione D, Baruchel A, Dombret H, et al. Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias. Leukemia. 2006;20:82-6 pubmed
Woodard G, Lin L, Zhang J, Agarwal S, Marx S, Simonds W. Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Oncogene. 2005;24:1272-6 pubmed
产品信息
产品名称 :
细胞周期蛋白D1(DCS-6)抗体
基因名称 :
CCND1
规格 :
200微克/毫升
价格 :
279美元
目录号 :
sc-20044
类型 :
单克隆
宿主 :
小鼠单克隆
抗原 :
细胞周期蛋白D1
反应物种 :
m, r, h
应用 :
免疫印迹, 免疫沉淀, IF, 免疫组化(P), FCM, 酶联免疫吸附测定
表位 :
FL(人类)
交货时间 :
在下午三点前下订单在美国的次日送达;从我们美国的办公室通过国际航运两日后送达;在我们的欧洲办事处下订单次日运抵欧洲客户
更多信息或购买 :
公司信息
圣克鲁斯生物技术
上海浦东新区建业路315号2号楼1-6号
asia@scbio.cn
http://www.scbt.com/zh/
800-820-8626
公司总部: 美国
圣克鲁斯生物技术公司拥有最高的质量承诺和客户服务。