产品简要
公司名称 :
圣克鲁斯生物技术
产品类型 :
抗体
产品名称 :
N-Ras (F155) Antibody
目录 :
sc-31
规格 :
100微克/毫升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
F155
反应物种 :
仓鼠, 人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片, reverse phase protein lysate microarray, 其他, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 54
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:150; 图 3f
Loureiro J, Raimundo L, Calheiros J, Carvalho C, Barcherini V, Lima N, et al. Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance. Cancers (Basel). 2021;13: pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:50; 图 1d
McMahon M, Contreras A, Holm M, Uechi T, Forester C, Pang X, et al. A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. elife. 2019;8: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:300; 图 1e, s2c
Hari P, Millar F, Tarrats N, Birch J, Quintanilla A, Rink C, et al. The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv. 2019;5:eaaw0254 pubmed 出版商
  • 免疫沉淀; 人类; 图 s2d
  • 免疫印迹; 人类; 图 s1b
Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, et al. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell. 2019;176:1113-1127.e16 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s1c
Hyrenius Wittsten A, Pilheden M, Sturesson H, Hansson J, Walsh M, Song G, et al. De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia. Nat Commun. 2018;9:1770 pubmed 出版商
  • 其他; 人类; 图 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 s2a
  • 免疫沉淀; 人类; 表 1
  • 免疫细胞化学; 人类; 1:100; 图 6b
  • 免疫印迹; 人类; 表 1
Waters A, Ozkan Dagliyan I, Vaseva A, Fer N, Strathern L, Hobbs G, et al. Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. Sci Signal. 2017;10: pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, et al. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017;31:685-696.e6 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 3a
. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed 出版商
  • 免疫印迹; 人类
Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Nowacka J, Baumgartner C, Pelorosso C, Roth M, Zuber J, Baccarini M. MEK1 is required for the development of NRAS-driven leukemia. Oncotarget. 2016;7:80113-80130 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:1000; 图 s2
Anta B, Pérez Rodríguez A, Castro J, García Domínguez C, Ibiza S, Martínez N, et al. PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes. Cell Death Dis. 2016;7:e2311 pubmed 出版商
  • 免疫印迹; 人类; 图 5b
Ye S, Song W, Xu X, Zhao X, Yang L. IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF-1 degradation by miR-195. FEBS Lett. 2016;590:1641-50 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 7
Tasdemir N, Banito A, Roe J, Alonso Curbelo D, Camiolo M, Tschaharganeh D, et al. BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance. Cancer Discov. 2016;6:612-29 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
Chen Y, Zheng Y, You X, Yu M, Fu G, Su X, et al. Kras Is Critical for B Cell Lymphopoiesis. J Immunol. 2016;196:1678-85 pubmed 出版商
  • 免疫印迹; 人类; 图 5c
Kloet D, Polderman P, Eijkelenboom A, Smits L, van Triest M, van den Berg M, et al. FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1). Biochem J. 2015;469:289-98 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1
Zhu M, Guo J, Li W, Lu Y, Fu S, Xie X, et al. Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells. Oncotarget. 2015;6:12196-208 pubmed
  • 免疫组化-石蜡切片; 小鼠; 1:100
Raouf S, Weston C, Yucel N. Registered report: senescence surveillance of pre-malignant hepatocytes limits liver cancer development. elife. 2015;4: pubmed 出版商
  • 免疫印迹; 人类
BENTLEY C, Jurinka S, Kljavin N, Vartanian S, Ramani S, Gonzalez L, et al. A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation. Biochem J. 2013;452:313-20 pubmed 出版商
  • 免疫印迹; 人类
Vartanian S, BENTLEY C, Brauer M, Li L, Shirasawa S, Sasazuki T, et al. Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines. J Biol Chem. 2013;288:2403-13 pubmed 出版商
  • 免疫印迹; 仓鼠
van der Hoeven D, Cho K, Ma X, Chigurupati S, Parton R, Hancock J. Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol Cell Biol. 2013;33:237-51 pubmed 出版商
  • 免疫细胞化学; 犬
  • 免疫印迹; 犬
Cho K, Park J, Piggott A, Salim A, Gorfe A, Parton R, et al. Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins. J Biol Chem. 2012;287:43573-84 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 1
Fotiadou P, Takahashi C, Rajabi H, Ewen M. Wild-type NRas and KRas perform distinct functions during transformation. Mol Cell Biol. 2007;27:6742-55 pubmed
Gastebois C, Chanon S, Rome S, Durand C, Pelascini E, Jalabert A, et al. Transition from physical activity to inactivity increases skeletal muscle miR-148b content and triggers insulin resistance. Physiol Rep. 2016;4: pubmed 出版商
Hoare M, Ito Y, Kang T, Weekes M, Matheson N, Patten D, et al. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 2016;18:979-92 pubmed 出版商
Zhou M, Wiener H, Su W, Zhou Y, Liot C, Ahearn I, et al. VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking. J Cell Biol. 2016;214:445-58 pubmed 出版商
Silvers C, Liu Y, Wu C, Miyamoto H, Messing E, Lee Y. Identification of extracellular vesicle-borne periostin as a feature of muscle-invasive bladder cancer. Oncotarget. 2016;7:23335-45 pubmed 出版商
Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior I, et al. Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Cell Commun Signal. 2016;14:5 pubmed 出版商
Brossier N, Prechtl A, Longo J, Barnes S, Wilson L, Byer S, et al. Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells. J Neuropathol Exp Neurol. 2015;74:568-86 pubmed 出版商
Leikam C, Hufnagel A, Otto C, Murphy D, Mühling B, Kneitz S, et al. In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells. Cell Death Dis. 2015;6:e1711 pubmed 出版商
Ceccarelli V, Nocentini G, Billi M, Racanicchi S, Riccardi C, Roberti R, et al. Eicosapentaenoic acid activates RAS/ERK/C/EBP? pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. PLoS ONE. 2014;9:e85025 pubmed 出版商
Ballarín González B, Lassen L, Jessen R, Füchtbauer A, Füchtbauer E, Pedersen F. Deregulated Nras expression in knock-in animals harboring a gammaretroviral long terminal repeat at the Nras/Csde1 locus. PLoS ONE. 2013;8:e56029 pubmed 出版商
Kaplan F, Kugel C, Dadpey N, Shao Y, Abel E, Aplin A. SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor. J Biol Chem. 2012;287:41797-807 pubmed 出版商
Litlekalsoy J, Hostmark J, Costea D, Illemann M, Laerum O. Time-dependent biological differences in molecular markers of high-grade urothelial cancer over 7 decades (ras proteins, pTEN, uPAR, PAI-1 and MMP-9). Virchows Arch. 2012;461:541-51 pubmed 出版商
Han D, Spengler B, Ross R. Increased wild-type N-ras activation by neurofibromin down-regulation increases human neuroblastoma stem cell malignancy. Genes Cancer. 2011;2:1034-43 pubmed 出版商
Lang M, Yang S, Zhao C, Sun G, Murai K, Wu X, et al. Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells. PLoS ONE. 2012;7:e36248 pubmed 出版商
Linley A, Mathieu M, Miles A, Rees R, McArdle S, Regad T. The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation in vivo. J Biol Chem. 2012;287:13633-43 pubmed 出版商
Cho K, Hill M, Chigurupati S, Du G, Parton R, Hancock J. Therapeutic levels of the hydroxmethylglutaryl-coenzyme A reductase inhibitor lovastatin activate ras signaling via phospholipase D2. Mol Cell Biol. 2011;31:1110-20 pubmed 出版商
Steinbrunn T, Stühmer T, Gattenlohner S, Rosenwald A, Mottok A, Unzicker C, et al. Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival. Blood. 2011;117:1998-2004 pubmed 出版商
Kreeger P, Wang Y, Haigis K, Lauffenburger D. Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation. Integr Biol (Camb). 2010;2:202-8 pubmed 出版商
Vignola M, Kashatus D, Taylor G, Counter C, Valdivia R. cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis. J Biol Chem. 2010;285:21625-35 pubmed 出版商
VanBrocklin M, Robinson J, Lastwika K, Khoury J, Holmen S. Targeted delivery of NRASQ61R and Cre-recombinase to post-natal melanocytes induces melanoma in Ink4a/Arflox/lox mice. Pigment Cell Melanoma Res. 2010;23:531-41 pubmed 出版商
Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, et al. A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth. BMC Cancer. 2009;9:198 pubmed 出版商
Kim S, Lee Y, Kim Y, Bahk Y. A Proteomic approach for protein-profiling the oncogenic ras induced transformation (H-, K-, and N-Ras) in NIH/3T3 mouse embryonic fibroblasts. Proteomics. 2008;8:3082-93 pubmed 出版商
Li M, Ong S, Rajwa B, Thieu V, Geahlen R, Harrison M. The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1. Mol Cell Biol. 2008;28:630-41 pubmed
Schwechter B, Millet L, Levin L. Histone deacetylase inhibition-mediated differentiation of RGC-5 cells and interaction with survival. Invest Ophthalmol Vis Sci. 2007;48:2845-57 pubmed
Lutterbach B, Zeng Q, Davis L, Hatch H, Hang G, Kohl N, et al. Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival. Cancer Res. 2007;67:2081-8 pubmed
Keller J, Franklin J, Graves Deal R, Friedman D, Whitwell C, Coffey R. Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium. J Cell Physiol. 2007;210:740-9 pubmed
Keller J, Haigis K, Franklin J, Whitehead R, Jacks T, Coffey R. Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex. Oncogene. 2007;26:3051-9 pubmed
Ehmann F, Horn S, Garcia Palma L, Wegner W, Fiedler W, Giehl K, et al. Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations. Leuk Lymphoma. 2006;47:1387-91 pubmed
Mattingly R, Kraniak J, Dilworth J, Mathieu P, Bealmear B, Nowak J, et al. The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines. J Pharmacol Exp Ther. 2006;316:456-65 pubmed
Edin M, Juliano R. Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor. Mol Cell Biol. 2005;25:4466-75 pubmed
Boivin B, Villeneuve L, Farhat N, Chevalier D, Allen B. Sub-cellular distribution of endothelin signaling pathway components in ventricular myocytes and heart: lack of preformed caveolar signalosomes. J Mol Cell Cardiol. 2005;38:665-76 pubmed
产品信息
产品名称 :
N-Ras (F155) Antibody
基因名称 :
NRAS
规格 :
100微克/毫升
目录号 :
sc-31
类型 :
单克隆
宿主 :
小鼠单克隆
抗原 :
N-Ras
反应物种 :
m, r, h
应用 :
免疫印迹, 免疫沉淀, IF, 免疫组化(P)
表位 :
FL
交货时间 :
在下午三点前下订单在美国的次日送达;从我们美国的办公室通过国际航运两日后送达;在我们的欧洲办事处下订单次日运抵欧洲客户
更多信息或购买 :
公司信息
圣克鲁斯生物技术
上海浦东新区建业路315号2号楼1-6号
asia@scbio.cn
http://www.scbt.com/zh/
800-820-8626
公司总部: 美国
圣克鲁斯生物技术公司拥有最高的质量承诺和客户服务。