出版应用/物种/样本/稀释 | 参考文献 |
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| Qamar S, Wang G, Randle S, Ruggeri F, Varela J, Lin J, et al. FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions. Cell. 2018;173:720-734.e15 pubmed 出版商
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- 免疫细胞化学; 小鼠; 1:1000; 图 6b
- 免疫印迹; 小鼠; 1:1000; 图 6a
| Maharjan N, Künzli C, Buthey K, Saxena S. C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress. Mol Neurobiol. 2017;54:3062-3077 pubmed 出版商
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| Fletcher C, Godfrey J, Shibakawa A, Bushell M, Bevan C. A novel role for GSK3? as a modulator of Drosha microprocessor activity and MicroRNA biogenesis. Nucleic Acids Res. 2016;: pubmed
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| Hill S, Mordes D, Cameron L, Neuberg D, Landini S, Eggan K, et al. Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proc Natl Acad Sci U S A. 2016;113:E7701-E7709 pubmed
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- 免疫组化; 小鼠; 图 2a, 2b
- 免疫沉淀; 人类; 图 1a, 5a
- 免疫细胞化学; 人类; 图 1b, 2c, 2d, 5b, 5d
- 免疫印迹; 人类; 图 1f
| Yamaguchi A, Takanashi K. FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription. Sci Rep. 2016;6:35195 pubmed 出版商
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| Klein G, Mathé C, Biola Clier M, Devineau S, Drouineau E, Hatem E, et al. RNA-binding proteins are a major target of silica nanoparticles in cell extracts. Nanotoxicology. 2016;10:1555-1564 pubmed
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| West J, Mito M, Kurosaka S, Takumi T, Tanegashima C, Chujo T, et al. Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization. J Cell Biol. 2016;214:817-30 pubmed 出版商
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- 免疫组化-冰冻切片; 小鼠; 1:500; 图 6
- 免疫印迹; 小鼠; 1:1000; 图 6
- 免疫组化-石蜡切片; 人类; 1:500; 图 8
| Alves S, Marais T, Biferi M, Furling D, Marinello M, El Hachimi K, et al. Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins. Mol Neurodegener. 2016;11:58 pubmed 出版商
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| Kamelgarn M, Chen J, Kuang L, Arenas A, Zhai J, Zhu H, et al. Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS. Biochim Biophys Acta. 2016;1862:2004-14 pubmed 出版商
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- 免疫沉淀; 小鼠; 图 S1c
- 免疫印迹; 人类; 1:100; 图 5b
| Kapeli K, Pratt G, Vu A, Hutt K, Martinez F, Sundararaman B, et al. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. Nat Commun. 2016;7:12143 pubmed 出版商
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- proximity ligation assay; 人类; 1:500; 图 s4
- 免疫细胞化学; 人类; 1:500; 图 5
| Ansseau E, Eidahl J, Lancelot C, Tassin A, Mattéotti C, Yip C, et al. Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation. PLoS ONE. 2016;11:e0146893 pubmed 出版商
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- 免疫组化-石蜡切片; 大鼠; 1:200; 图 1
- 免疫印迹; 大鼠; 1:400; 图 1
| Schoen M, Reichel J, Demestre M, Putz S, Deshpande D, Proepper C, et al. Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons. Front Cell Neurosci. 2015;9:496 pubmed 出版商
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- ChIP-Seq; 人类; 图 2
- 免疫印迹; 人类; 1:2000; 图 s10
| Luo Y, Blechingberg J, Fernandes A, Li S, Fryland T, Børglum A, et al. EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions. BMC Genomics. 2015;16:929 pubmed 出版商
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| Lenzi J, De Santis R, de Turris V, Morlando M, Laneve P, Calvo A, et al. ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons. Dis Model Mech. 2015;8:755-66 pubmed 出版商
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- cross-linking immunoprecipitation; 小鼠; 图 1
- 免疫沉淀; 小鼠; 图 5
- 免疫印迹; 小鼠; 图 5
| Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, et al. Position-specific binding of FUS to nascent RNA regulates mRNA length. Genes Dev. 2015;29:1045-57 pubmed 出版商
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| Sun S, Ling S, Qiu J, Albuquerque C, Zhou Y, Tokunaga S, et al. ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nat Commun. 2015;6:6171 pubmed 出版商
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| Nakamura M, Murray M, Lin W, Kusaka H, Dickson D. Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease. Am J Neurodegener Dis. 2014;3:93-102 pubmed
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| Wang T, Jiang X, Chen G, Xu J. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Neurobiol Aging. 2015;36:527-35 pubmed 出版商
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| Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, et al. Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. EMBO Mol Med. 2013;5:221-34 pubmed 出版商
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| Morlando M, Dini Modigliani S, Torrelli G, Rosa A, Di Carlo V, Caffarelli E, et al. FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment. EMBO J. 2012;31:4502-10 pubmed 出版商
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| Tyzack G, Luisier R, Taha D, Neeves J, Modic M, Mitchell J, et al. Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis. Brain. 2019;142:2572-2580 pubmed 出版商
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| De Santis R, Alfano V, de Turris V, Colantoni A, Santini L, Garone M, et al. Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis. Cell Rep. 2019;27:3818-3831.e5 pubmed 出版商
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| Tischbein M, Baron D, Lin Y, Gall K, Landers J, Fallini C, et al. The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing. J Biol Chem. 2019;: pubmed 出版商
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| An H, Skelt L, Notaro A, Highley J, Fox A, La Bella V, et al. ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles. Acta Neuropathol Commun. 2019;7:7 pubmed 出版商
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| Capauto D, Colantoni A, Lu L, Santini T, Peruzzi G, Biscarini S, et al. A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons. Mol Neurobiol. 2018;55:7635-7651 pubmed 出版商
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| Bailey J, Shen W, Liang X, Crooke S. Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides. Nucleic Acids Res. 2017;45:10649-10671 pubmed 出版商
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| Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, et al. FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Nat Commun. 2017;8:14741 pubmed 出版商
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| Kukharsky M, Quintiero A, Matsumoto T, Matsukawa K, An H, Hashimoto T, et al. Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis. Mol Neurodegener. 2015;10:20 pubmed 出版商
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| Schwartz J, Podell E, Han S, Berry J, EGGAN K, Cech T. FUS is sequestered in nuclear aggregates in ALS patient fibroblasts. Mol Biol Cell. 2014;25:2571-8 pubmed 出版商
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| Shelkovnikova T, Robinson H, Troakes C, Ninkina N, Buchman V. Compromised paraspeckle formation as a pathogenic factor in FUSopathies. Hum Mol Genet. 2014;23:2298-312 pubmed 出版商
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| Fujioka Y, Ishigaki S, Masuda A, Iguchi Y, Udagawa T, Watanabe H, et al. FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD. Sci Rep. 2013;3:2388 pubmed 出版商
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| Nishimoto Y, Nakagawa S, Hirose T, Okano H, Takao M, Shibata S, et al. The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis. Mol Brain. 2013;6:31 pubmed 出版商
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| Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S. Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro. Biochim Biophys Acta. 2013;1832:1129-35 pubmed 出版商
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| Yamaguchi A, Kitajo K. The effect of PRMT1-mediated arginine methylation on the subcellular localization, stress granules, and detergent-insoluble aggregates of FUS/TLS. PLoS ONE. 2012;7:e49267 pubmed 出版商
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| Blechingberg J, Luo Y, Bolund L, Damgaard C, Nielsen A. Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions. PLoS ONE. 2012;7:e46251 pubmed 出版商
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| Blechingberg J, Holm I, Nielsen A. Characterization and expression analysis in the developing embryonic brain of the porcine FET family: FUS, EWS, and TAF15. Gene. 2012;493:27-35 pubmed 出版商
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| Kim S, Shanware N, Bowler M, Tibbetts R. Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. J Biol Chem. 2010;285:34097-105 pubmed 出版商
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| Gal J, Zhang J, Kwinter D, Zhai J, Jia H, Jia J, et al. Nuclear localization sequence of FUS and induction of stress granules by ALS mutants. Neurobiol Aging. 2011;32:2323.e27-40 pubmed 出版商
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| Deng H, Zhai H, Bigio E, Yan J, Fecto F, Ajroud K, et al. FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis. Ann Neurol. 2010;67:739-48 pubmed 出版商
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| Boccardo E, Manzini Baldi C, Carvalho A, Rabachini T, Torres C, Barreta L, et al. Expression of human papillomavirus type 16 E7 oncoprotein alters keratinocytes expression profile in response to tumor necrosis factor-alpha. Carcinogenesis. 2010;31:521-31 pubmed 出版商
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| Neumann M, Roeber S, Kretzschmar H, Rademakers R, Baker M, Mackenzie I. Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease. Acta Neuropathol. 2009;118:605-16 pubmed 出版商
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