产品简要
公司名称 :
圣克鲁斯生物技术
产品类型 :
抗体
产品名称 :
Raf-B (F-7) Antibody
目录 :
sc-5284
规格 :
200微克/毫升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
F-7
反应物种 :
仓鼠, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, reverse phase protein lysate microarray, proximity ligation assay, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 70
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 s2b
Leon K, Buj R, Lesko E, Dahl E, Chen C, Tangudu N, et al. DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A. J Cell Biol. 2021;220: pubmed 出版商
  • 免疫印迹; 人类; 1:3000; 图 2c
Gualtieri A, Kyprianou N, Gregory L, Vignola M, Nicholson J, Tan R, et al. Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans. Nat Commun. 2021;12:2028 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1a
Buj R, Leon K, Anguelov M, Aird K. Suppression of p16 alleviates the senescence-associated secretory phenotype. Aging (Albany NY). 2021;13:3290-3312 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5c
Schwartz J, Ma J, Lamprecht T, Walsh M, Wang S, Bryant V, et al. The genomic landscape of pediatric myelodysplastic syndromes. Nat Commun. 2017;8:1557 pubmed 出版商
  • 免疫印迹; 人类; 图 3e
Yurugi H, Marini F, Weber C, David K, Zhao Q, Binder H, et al. Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene. 2017;36:4778-4789 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed 出版商
  • reverse phase protein lysate microarray; 人类; 图 3a
. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Riverso M, Montagnani V, Stecca B. KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth. Oncogene. 2017;36:3322-3333 pubmed 出版商
  • proximity ligation assay; 仓鼠; 图 3d
Siljamäki E, Abankwa D. SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling. Mol Cell Biol. 2016;36:2612-25 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 9
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 3
Raguz J, Jerić I, Niault T, Nowacka J, Kuzet S, Rupp C, et al. Epidermal RAF prevents allergic skin disease. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 人类; 图 6b
Kemper K, Krijgsman O, Kong X, Cornelissen Steijger P, Shahrabi A, Weeber F, et al. BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts. Cell Rep. 2016;16:263-277 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s1
Chatelle C, Hövermann D, Muller A, Wagner H, Weber W, Radziwill G. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Sci Rep. 2016;6:23713 pubmed 出版商
  • 免疫沉淀; 人类; 图 2
  • 免疫印迹; 人类; 图 2
Budina Kolomets A, Webster M, Leu J, Jennis M, Krepler C, Guerrini A, et al. HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors. Cancer Res. 2016;76:2720-30 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 表 2
Bhargava A, Pelech S, Woodard B, Kerwin J, Maherali N. Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 人类; 图 1
Lenain C, Gusyatiner O, Douma S, van den Broek B, Peeper D. Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence. Carcinogenesis. 2015;36:1263-74 pubmed 出版商
  • 免疫印迹; 人类; 图 S3A
Wiersma V, de Bruyn M, Wei Y, van Ginkel R, Hirashima M, Niki T, et al. The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy. 2015;11:1373-88 pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Condelli V, Maddalena F, Sisinni L, Lettini G, Matassa D, Piscazzi A, et al. Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma. Oncotarget. 2015;6:22298-309 pubmed
  • 免疫沉淀; 人类; 1:1000; 图 2
  • 免疫细胞化学; 人类; 1:25; 图 5
Ho J, Nadeem A, Rydström A, Puthia M, Svanborg C. Targeting of nucleotide-binding proteins by HAMLET--a conserved tumor cell death mechanism. Oncogene. 2016;35:897-907 pubmed 出版商
  • 免疫印迹; 人类
Kugel C, Hartsough E, Davies M, Setiady Y, Aplin A. Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor. Cancer Res. 2014;74:4122-32 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:500; 图 4b
Zeng L, Ehrenreiter K, Menon J, Menard R, Kern F, Nakazawa Y, et al. RKIP regulates MAP kinase signaling in cells with defective B-Raf activity. Cell Signal. 2013;25:1156-65 pubmed 出版商
  • 免疫印迹; 仓鼠
van der Hoeven D, Cho K, Ma X, Chigurupati S, Parton R, Hancock J. Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol Cell Biol. 2013;33:237-51 pubmed 出版商
Yeh C, Bellon M, Wang F, Zhang H, Fu L, Nicot C. Loss of FBXW7-mediated degradation of BRAF elicits resistance to BET inhibitors in adult T cell leukemia cells. Mol Cancer. 2020;19:139 pubmed 出版商
Palušová V, Renzova T, Verlande A, Vaclová T, Medková M, Cetlová L, et al. Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds. Cancers (Basel). 2020;12: pubmed 出版商
Pathria G, Lee J, Hasnis E, Tandoc K, Scott D, Verma S, et al. Translational reprogramming marks adaptation to asparagine restriction in cancer. Nat Cell Biol. 2019;21:1590-1603 pubmed 出版商
Ko T, Sharma R, Li S. Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAFV600E expression. Oncogene. 2019;: pubmed 出版商
Hey F, Andreadi C, Noble C, Patel B, Jin H, Kamata T, et al. Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK. Heliyon. 2018;4:e01065 pubmed 出版商
Uenaka T, Satake W, Cha P, Hayakawa H, Baba K, Jiang S, et al. In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson's disease. Hum Mol Genet. 2018;27:3974-3985 pubmed 出版商
Ohanna M, Cerezo M, Nottet N, Bille K, Didier R, Béranger G, et al. Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype. Genes Dev. 2018;32:448-461 pubmed 出版商
Gao Y, Chang M, McKay D, Na N, Zhou B, Yaeger R, et al. Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties. Cancer Discov. 2018;8:648-661 pubmed 出版商
Chen M, Wan L, Zhang J, Zhang J, Méndez L, Clohessy J, et al. Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. Nat Commun. 2018;9:159 pubmed 出版商
Kong X, Kuilman T, Shahrabi A, Boshuizen J, Kemper K, Song J, et al. Cancer drug addiction is relayed by an ERK2-dependent phenotype switch. Nature. 2017;550:270-274 pubmed 出版商
Nieto P, Ambrogio C, Esteban Burgos L, Gomez Lopez G, Blasco M, Yao Z, et al. A Braf kinase-inactive mutant induces lung adenocarcinoma. Nature. 2017;548:239-243 pubmed 出版商
Yao Z, Yaeger R, Rodrik Outmezguine V, Tao A, Torres N, Chang M, et al. Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS. Nature. 2017;548:234-238 pubmed 出版商
Takahashi M, Li Y, Dillon T, Kariya Y, Stork P. Phosphorylation of the C-Raf N Region Promotes Raf Dimerization. Mol Cell Biol. 2017;37: pubmed 出版商
Carroll B, Nelson G, Rabanal Ruiz Y, Kucheryavenko O, Dunhill Turner N, Chesterman C, et al. Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing. J Cell Biol. 2017;216:1949-1957 pubmed 出版商
Wei W, Sun Z, Shen C, Song H, Zhang X, Qiu Z, et al. Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer. Theranostics. 2017;7:987-1001 pubmed 出版商
van Veen J, Pringle D, McMahon M. P2A-Fluorophore Tagging of BRAF Tightly Links Expression to Fluorescence In Vivo. PLoS ONE. 2016;11:e0157661 pubmed 出版商
Manchado E, Weissmueller S, Morris J, Chen C, Wullenkord R, Lujambio A, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016;534:647-51 pubmed
Bhargava A, Anant M, Mack H. Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. elife. 2016;5: pubmed 出版商
Lakshmanan A, Scarberry D, Green J, Zhang X, Selmi Ruby S, Jhiang S. Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin. Oncotarget. 2015;6:31792-804 pubmed 出版商
Karreth F, Reschke M, Ruocco A, Ng C, Chapuy B, Léopold V, et al. The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo. Cell. 2015;161:319-32 pubmed 出版商
Kaplon J, Zheng L, Meissl K, Chaneton B, Selivanov V, Mackay G, et al. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature. 2013;498:109-12 pubmed 出版商
Le K, Blomain E, Rodeck U, Aplin A. Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells. Pigment Cell Melanoma Res. 2013;26:509-17 pubmed 出版商
Basile K, Aplin A. Downregulation of Noxa by RAF/MEK inhibition counteracts cell death response in mutant B-RAF melanoma cells. Am J Cancer Res. 2012;2:726-35 pubmed
Kaplan F, Kugel C, Dadpey N, Shao Y, Abel E, Aplin A. SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor. J Biol Chem. 2012;287:41797-807 pubmed 出版商
Subramanian R, Yamakawa A. Combination therapy targeting Raf-1 and MEK causes apoptosis of HCT116 colon cancer cells. Int J Oncol. 2012;41:1855-62 pubmed 出版商
Shao Y, Aplin A. BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma. Cell Death Differ. 2012;19:2029-39 pubmed 出版商
Torti V, Wojciechowicz D, Hu W, John Baptiste A, Evering W, Troche G, et al. Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901. Mol Cancer Ther. 2012;11:2274-83 pubmed 出版商
Rodrigues L, Chung Y, Al Saffar N, Sharp S, Jackson L, Banerji U, et al. Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy. BMC Res Notes. 2012;5:250 pubmed 出版商
Wang Z, Feng Y, Bardeesy N, Bardessy N, WONG K, Liu X, et al. Temporal dissection of K-ras(G12D) mutant in vitro and in vivo using a regulatable K-ras(G12D) mouse allele. PLoS ONE. 2012;7:e37308 pubmed 出版商
Flockhart R, Webster D, Qu K, Mascarenhas N, Kovalski J, Kretz M, et al. BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration. Genome Res. 2012;22:1006-14 pubmed 出版商
Suram A, Kaplunov J, Patel P, Ruan H, Cerutti A, Boccardi V, et al. Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J. 2012;31:2839-51 pubmed 出版商
Piscazzi A, Costantino E, Maddalena F, Natalicchio M, Gerardi A, Antonetti R, et al. Activation of the RAS/RAF/ERK signaling pathway contributes to resistance to sunitinib in thyroid carcinoma cell lines. J Clin Endocrinol Metab. 2012;97:E898-906 pubmed 出版商
Giles N, Pavey S, Pinder A, Gabrielli B. Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin. Br J Dermatol. 2012;166:362-71 pubmed 出版商
Klein R, Higgins P. A switch in RND3-RHOA signaling is critical for melanoma cell invasion following mutant-BRAF inhibition. Mol Cancer. 2011;10:114 pubmed 出版商
Bommarito A, Richiusa P, Carissimi E, Pizzolanti G, Rodolico V, Zito G, et al. BRAFV600E mutation, TIMP-1 upregulation, and NF-κB activation: closing the loop on the papillary thyroid cancer trilogy. Endocr Relat Cancer. 2011;18:669-85 pubmed 出版商
Hömig Hölzel C, van Doorn R, Vogel C, Germann M, Cecchini M, Verdegaal E, et al. Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence. EMBO J. 2011;30:1753-65 pubmed 出版商
Little A, Balmanno K, Sale M, Newman S, Dry J, Hampson M, et al. Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells. Sci Signal. 2011;4:ra17 pubmed 出版商
Karki P, Li X, Schrama D, Fliegel L. B-Raf associates with and activates the NHE1 isoform of the Na+/H+ exchanger. J Biol Chem. 2011;286:13096-105 pubmed 出版商
López Vicente L, Pons B, Coch L, Teixidó C, Hernandez Losa J, Armengol G, et al. RSK4 inhibition results in bypass of stress-induced and oncogene-induced senescence. Carcinogenesis. 2011;32:470-6 pubmed 出版商
Valluet A, Hmitou I, Davis S, Druillennec S, Larcher M, Laroche S, et al. B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse. PLoS ONE. 2010;5:e15272 pubmed 出版商
Smith F, Langeberg L, Cellurale C, Pawson T, Morrison D, Davis R, et al. AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol. 2010;12:1242-9 pubmed 出版商
Adams D, Wang Y, Mak P, Chyba J, Shalizi O, Matzen J, et al. Cellular Ser/Thr-kinase assays using generic peptide substrates. Curr Chem Genomics. 2008;1:54-64 pubmed 出版商
Shu F, Ramineni S, Hepler J. RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. Cell Signal. 2010;22:366-76 pubmed 出版商
Noble C, Mercer K, Hussain J, Carragher L, Giblett S, Hayward R, et al. CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation. Mol Cell. 2008;31:862-72 pubmed 出版商
Provot S, Nachtrab G, Paruch J, Chen A, Silva A, Kronenberg H. A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes. Mol Cell Biol. 2008;28:344-57 pubmed
Nagao S, Nishii K, Yoshihara D, Kurahashi H, Nagaoka K, Yamashita T, et al. Calcium channel inhibition accelerates polycystic kidney disease progression in the Cy/+ rat. Kidney Int. 2008;73:269-77 pubmed
Granas C, Lundholt B, Loechel F, Pedersen H, Bjørn S, Linde V, et al. Identification of RAS-mitogen-activated protein kinase signaling pathway modulators in an ERF1 redistribution screen. J Biomol Screen. 2006;11:423-34 pubmed
McPhillips F, Mullen P, MacLeod K, Sewell J, Monia B, Cameron D, et al. Raf-1 is the predominant Raf isoform that mediates growth factor-stimulated growth in ovarian cancer cells. Carcinogenesis. 2006;27:729-39 pubmed
Michaloglou C, Vredeveld L, Soengas M, Denoyelle C, Kuilman T, van der Horst C, et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature. 2005;436:720-4 pubmed
产品信息
产品名称 :
Raf-B (F-7) Antibody
基因名称 :
BRAF
规格 :
200微克/毫升
目录号 :
sc-5284
类型 :
单克隆
宿主 :
小鼠单克隆
抗原 :
Raf-B
反应物种 :
m, r, h
应用 :
免疫印迹, 免疫沉淀, IF, 免疫组化(P), 酶联免疫吸附测定
表位 :
12-156(人类)
交货时间 :
在下午三点前下订单在美国的次日送达;从我们美国的办公室通过国际航运两日后送达;在我们的欧洲办事处下订单次日运抵欧洲客户
更多信息或购买 :
公司信息
圣克鲁斯生物技术
上海浦东新区建业路315号2号楼1-6号
asia@scbio.cn
http://www.scbt.com/zh/
800-820-8626
公司总部: 美国
圣克鲁斯生物技术公司拥有最高的质量承诺和客户服务。