产品简要
公司名称 :
圣克鲁斯生物技术
产品类型 :
抗体
产品名称 :
N-Myc(B8.4。 B)抗体
目录 :
sc-53993
规格 :
200微克/毫升
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
B8.4。 B
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, ChIP-Seq, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 52
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 5b
Dong F, Chen M, Jiang L, Shen Z, Ma L, Han C, et al. PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications. Front Cell Dev Biol. 2021;9:673258 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 s9g
  • ChIP-Seq; 小鼠; 图 6a
  • 免疫印迹; 小鼠; 1:200; 图 s2e
Brady N, Bagadion A, Singh R, Conteduca V, Van Emmenis L, Arceci E, et al. Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer. Nat Commun. 2021;12:3372 pubmed 出版商
  • 流式细胞仪; 人类; 图 4b
Kuchen E, Becker N, Claudino N, Hofer T. Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2a
Liu P, Tee A, Milazzo G, Hannan K, Maag J, Mondal S, et al. The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35. Nat Commun. 2019;10:5026 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 4e, 4h
Menon V, Thomas R, Elgueta C, Horl M, Osborn T, Hallett P, et al. Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells. Stem Cells. 2019;37:1293-1306 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2c
Mooney M, Geerts D, Kort E, Bachmann A. Anti-tumor effect of sulfasalazine in neuroblastoma. Biochem Pharmacol. 2019;162:237-249 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 5c
  • 免疫印迹; 小鼠; 图 5c
Mirzamohammadi F, Kozlova A, Papaioannou G, Paltrinieri E, Ayturk U, Kobayashi T. Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. Nat Commun. 2018;9:1352 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5b
Otto T, Candido S, Pilarz M, Sicinska E, Bronson R, Bowden M, et al. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017;114:10660-10665 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 s9a
van Groningen T, Koster J, Valentijn L, Zwijnenburg D, Akogul N, Hasselt N, et al. Neuroblastoma is composed of two super-enhancer-associated differentiation states. Nat Genet. 2017;49:1261-1266 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 1a
Xue C, Yu D, Gherardi S, Koach J, Milazzo G, Gamble L, et al. MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4. Oncotarget. 2016;7:54937-54951 pubmed 出版商
  • 免疫印迹; 人类; 图 s2b
Powers J, Tsanov K, Pearson D, Roels F, Spina C, EBRIGHT R, et al. Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature. 2016;535:246-51 pubmed 出版商
  • ChIP-Seq; 人类; 图 5
  • 免疫印迹; 人类; 1:1000; 图 s3
Duffy D, Krstic A, Halasz M, Schwarzl T, Fey D, Iljin K, et al. Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma. Oncotarget. 2015;6:43182-201 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Xiao D, Ren P, Su H, Yue M, Xiu R, Hu Y, et al. Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2. Oncotarget. 2015;6:40655-66 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5a
  • 免疫印迹; 人类; 图 s1c
Petroni M, Sardina F, Heil C, Sahún Roncero M, Colicchia V, Veschi V, et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ. 2016;23:197-206 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 3A
  • 免疫沉淀; 人类; 图 1A
  • 免疫印迹; 人类; 图 1A
Amente S, Milazzo G, Sorrentino M, Ambrosio S, Di Palo G, Lania L, et al. Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. Oncotarget. 2015;6:14572-83 pubmed
  • 免疫印迹; 人类; 1:500; 图 s1
Chen L, Rousseau R, Middleton S, Nichols G, Newell D, Lunec J, et al. Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma. Oncotarget. 2015;6:10207-21 pubmed
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类; 图 6
Chayka O, D Acunto C, Middleton O, Arab M, Sala A. Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells. J Biol Chem. 2015;290:2198-212 pubmed 出版商
  • 免疫沉淀; 人类; 图 8
Gustafson W, Meyerowitz J, Nekritz E, Chen J, Benes C, Charron E, et al. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 2014;26:414-427 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫沉淀; 人类
Corvetta D, Chayka O, Gherardi S, D Acunto C, Cantilena S, Valli E, et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem. 2013;288:8332-41 pubmed 出版商
Zeineldin M, Federico S, Chen X, Fan Y, Xu B, Stewart E, et al. MYCN amplification and ATRX mutations are incompatible in neuroblastoma. Nat Commun. 2020;11:913 pubmed 出版商
Huang M, Tailor J, Zhen Q, Gillmor A, Miller M, Weishaupt H, et al. Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis. Cell Stem Cell. 2019;: pubmed 出版商
Yin Y, Xu L, Chang Y, Zeng T, Chen X, Wang A, et al. N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. Mol Cancer. 2019;18:11 pubmed 出版商
Hald Ø, Olsen L, Gallo Oller G, Elfman L, Løkke C, Kogner P, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2019;38:2800-2813 pubmed 出版商
Chen L, Pastorino F, Berry P, Bonner J, Kirk C, Wood K, et al. Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma. Int J Cancer. 2019;144:3146-3159 pubmed 出版商
Boboila S, Lopez G, Yu J, Banerjee D, Kadenhe Chiweshe A, Connolly E, et al. Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma. Oncogene. 2018;37:5451-5465 pubmed 出版商
Agarwal S, Milazzo G, Rajapakshe K, Bernardi R, Chen Z, Barberi E, et al. MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma. Oncotarget. 2018;9:20323-20338 pubmed 出版商
O Brien E, Selfe J, Martins A, Walters Z, Shipley J. The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells. BMC Cancer. 2018;18:217 pubmed 出版商
Ferrucci F, Ciaccio R, Monticelli S, Pigini P, Di Giacomo S, Purgato S, et al. MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma. Biochim Biophys Acta Gene Regul Mech. 2018;1861:235-245 pubmed 出版商
Chen L, Alexe G, Dharia N, Ross L, Iniguez A, Conway A, et al. CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2. J Clin Invest. 2018;128:446-462 pubmed 出版商
Bosse K, Raman P, Zhu Z, Lane M, Martinez D, Heitzeneder S, et al. Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. Cancer Cell. 2017;32:295-309.e12 pubmed 出版商
Dyberg C, Fransson S, Andonova T, Sveinbjörnsson B, Lännerholm Palm J, Olsen T, et al. Rho-associated kinase is a therapeutic target in neuroblastoma. Proc Natl Acad Sci U S A. 2017;114:E6603-E6612 pubmed 出版商
King B, Boccalatte F, Moran Crusio K, Wolf E, Wang J, Kayembe C, et al. The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells. Nat Immunol. 2016;17:1312-1321 pubmed 出版商
Eberhardt A, Hansen J, Koster J, Lotta L, Wang S, Livingstone E, et al. Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma. Oncotarget. 2016;7:63629-63639 pubmed 出版商
Murakami Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, et al. SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Sci Rep. 2016;6:31615 pubmed 出版商
Duffy D, Krstic A, Schwarzl T, Halasz M, Iljin K, Fey D, et al. Wnt signalling is a bi-directional vulnerability of cancer cells. Oncotarget. 2016;7:60310-60331 pubmed 出版商
Mandriota S, Valentijn L, Lesne L, Betts D, Marino D, Boudal Khoshbeen M, et al. Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism. Oncotarget. 2015;6:18558-76 pubmed
Evans L, Chen L, Milazzo G, Gherardi S, Perini G, Willmore E, et al. SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma. Cancer Lett. 2015;363:37-45 pubmed 出版商
Ambrosio S, Amente S, Napolitano G, Di Palo G, Lania L, Majello B. MYC impairs resolution of site-specific DNA double-strand breaks repair. Mutat Res. 2015;774:6-13 pubmed 出版商
Izumi H, Kaneko Y. Trim32 facilitates degradation of MYCN on spindle poles and induces asymmetric cell division in human neuroblastoma cells. Cancer Res. 2014;74:5620-30 pubmed 出版商
Murakami Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris J, Ichikawa H, et al. Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Cell Cycle. 2014;13:1115-31 pubmed 出版商
Lodrini M, Oehme I, Schroeder C, Milde T, Schier M, Kopp Schneider A, et al. MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma. Nucleic Acids Res. 2013;41:6018-33 pubmed 出版商
Watters K, Bryan K, Foley N, Meehan M, Stallings R. Expressional alterations in functional ultra-conserved non-coding RNAs in response to all-trans retinoic acid--induced differentiation in neuroblastoma cells. BMC Cancer. 2013;13:184 pubmed 出版商
Valli E, Trazzi S, Fuchs C, Erriquez D, Bartesaghi R, Perini G, et al. CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells. Biochim Biophys Acta. 2012;1819:1173-85 pubmed 出版商
Tivnan A, Orr W, Gubala V, Nooney R, Williams D, McDonagh C, et al. Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. PLoS ONE. 2012;7:e38129 pubmed 出版商
Varlakhanova N, Cotterman R, Bradnam K, Korf I, Knoepfler P. Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells. Epigenetics Chromatin. 2011;4:20 pubmed 出版商
Murphy D, Buckley P, Bryan K, Watters K, Koster J, van Sluis P, et al. Dissection of the oncogenic MYCN transcriptional network reveals a large set of clinically relevant cell cycle genes as drivers of neuroblastoma tumorigenesis. Mol Carcinog. 2011;50:403-11 pubmed 出版商
Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, et al. A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF. Cancer Res. 2011;71:404-12 pubmed 出版商
Muth D, Ghazaryan S, Eckerle I, Beckett E, Pöhler C, Batzler J, et al. Transcriptional repression of SKP2 is impaired in MYCN-amplified neuroblastoma. Cancer Res. 2010;70:3791-802 pubmed 出版商
Veas Perez de Tudela M, Delgado Esteban M, Cuende J, Bolanos J, Almeida A. Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up-regulating glutamate cysteine ligase. J Neurochem. 2010;113:819-25 pubmed 出版商
Murphy D, Buckley P, Bryan K, Das S, Alcock L, Foley N, et al. Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation. PLoS ONE. 2009;4:e8154 pubmed 出版商
Mestdagh P, Van Vlierberghe P, De Weer A, Muth D, Westermann F, Speleman F, et al. A novel and universal method for microRNA RT-qPCR data normalization. Genome Biol. 2009;10:R64 pubmed 出版商
Westermann F, Muth D, Benner A, Bauer T, Henrich K, Oberthuer A, et al. Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas. Genome Biol. 2008;9:R150 pubmed 出版商
产品信息
产品名称 :
N-Myc(B8.4。 B)抗体
基因名称 :
MYCN
规格 :
200微克/毫升
目录号 :
sc-53993
类型 :
单克隆
宿主 :
小鼠单克隆
抗原 :
N-Myc
反应物种 :
m, r, h
应用 :
免疫印迹, 免疫沉淀
表位 :
N末端(人类)
交货时间 :
在下午三点前下订单在美国的次日送达;从我们美国的办公室通过国际航运两日后送达;在我们的欧洲办事处下订单次日运抵欧洲客户
更多信息或购买 :
公司信息
圣克鲁斯生物技术
上海浦东新区建业路315号2号楼1-6号
asia@scbio.cn
http://www.scbt.com/zh/
800-820-8626
公司总部: 美国
圣克鲁斯生物技术公司拥有最高的质量承诺和客户服务。