产品简要
公司名称 :
圣克鲁斯生物技术
产品类型 :
抗体
产品名称 :
雌激素受体α(HC-20)
目录 :
sc-543
共轭标签 :
未共轭
反应物种 :
African green monkey, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 染色质免疫沉淀 , ChIP-Seq
更多信息或购买 :
文章摘录数: 64
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 1a
Lee Y, Ho S, Graves J, Xiao Y, Huang S, Lin W. CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer. Breast Cancer Res. 2019;21:134 pubmed 出版商
  • 免疫组化; 人类; 图 3c
Browne A, Charmsaz S, Varešlija D, Fagan A, Cosgrove N, Cocchiglia S, et al. Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer. Oncogene. 2018;37:2008-2021 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s6a
Khanal T, Choi K, Leung Y, Wang J, Kim D, Janakiram V, et al. Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Sci Rep. 2017;7:10662 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 s1d
  • 免疫印迹; 人类; 图 s5b
Toska E, Osmanbeyoglu H, Castel P, Chan C, Hendrickson R, Elkabets M, et al. PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D. Science. 2017;355:1324-1330 pubmed 出版商
  • 免疫印迹; 人类; 图 s4a
Teveroni E, Pellegrino M, Sacconi S, Calandra P, Cascino I, Farioli Vecchioli S, et al. Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activity. J Clin Invest. 2017;127:1531-1545 pubmed 出版商
  • 免疫组化; 大鼠; 图 102
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
McDermott M, Chumanevich A, Lim C, Liang J, Chen M, Altilia S, et al. Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget. 2017;8:12558-12575 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 1a
Konings G, Reynaert N, Delvoux B, Verhamme F, Bracke K, Brusselle G, et al. Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease. Mol Cell Endocrinol. 2017;443:23-31 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 3c
Rahman S, Zorca C, Traboulsi T, Noutahi E, Krause M, Mader S, et al. Single-cell profiling reveals that eRNA accumulation at enhancer-promoter loops is not required to sustain transcription. Nucleic Acids Res. 2017;45:3017-3030 pubmed 出版商
  • 免疫组化; 人类; 图 3d
Liao X, Li J, Dong X, Wang X, Xiang Y, Li H, et al. ER? inhibited myocardin-induced differentiation in uterine fibroids. Exp Cell Res. 2017;350:73-82 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Tu S, Lin Y, Huang C, Yang P, Chang H, Chang C, et al. Protein phosphatase Mg2+/Mn2+ dependent 1F promotes smoking-induced breast cancer by inactivating phosphorylated-p53-induced signals. Oncotarget. 2016;7:77516-77531 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 1a
Grindstad T, Skjefstad K, Andersen S, Ness N, Nordby Y, Al Saad S, et al. Estrogen receptors ? and ? and aromatase as independent predictors for prostate cancer outcome. Sci Rep. 2016;6:33114 pubmed 出版商
  • 免疫沉淀; African green monkey; 图 3
  • 免疫印迹; 人类; 图 1c
Higashimura Y, Kitakaze T, Harada N, Inui H, Nakano Y, Yamaji R. pVHL-mediated degradation of HIF-2? regulates estrogen receptor ? expression in normoxic breast cancer cells. FEBS Lett. 2016;590:2690-9 pubmed 出版商
  • 免疫组化; 大鼠; 1:700; 图 1f
Wang W, Kantorovich S, Babayan A, Hou B, Gall C, Lynch G. Estrogen's Effects on Excitatory Synaptic Transmission Entail Integrin and TrkB Transactivation and Depend Upon ?1-integrin function. Neuropsychopharmacology. 2016;41:2723-32 pubmed 出版商
  • ChIP-Seq; 人类; 图 2a
  • 染色质免疫沉淀 ; 人类; 图 3b
Varešlija D, McBryan J, Fagan A, Redmond A, Hao Y, Sims A, et al. Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity Resulting in Estrogen-Independent Metastatic Tumors. Clin Cancer Res. 2016;22:2765-77 pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Zhuang T, Zhu J, Li Z, Lorent J, Zhao C, Dahlman Wright K, et al. p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells. Oncotarget. 2015;6:43853-68 pubmed 出版商
  • 免疫沉淀; 人类; 图 2
  • 免疫印迹; 人类; 图 2
Bentin Toaldo C, Alexi X, Beelen K, Kok M, Hauptmann M, Jansen M, et al. Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13. BMC Cancer. 2015;15:588 pubmed 出版商
  • 免疫印迹; 人类; 图 4f
Wang Y, Zhou D, Chen S. SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1. Mol Endocrinol. 2014;28:935-48 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Wang Y, Xu W, Zhou D, Neckers L, Chen S. Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex. J Biol Chem. 2014;289:4815-26 pubmed 出版商
Abdalla M, Yamamoto T, Maehara K, Nogami J, Ohkawa Y, Miura H, et al. The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis. Nat Commun. 2019;10:3778 pubmed 出版商
Zhu C, Li L, Zhang Z, Bi M, Wang H, Su W, et al. A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer. Mol Cell. 2019;75:791-806.e8 pubmed 出版商
Rutkovsky A, Yeh E, Guest S, Findlay V, Muise Helmericks R, Armeson K, et al. Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer. BMC Cancer. 2019;19:491 pubmed 出版商
Toska E, Castel P, Chhangawala S, Arruabarrena Aristorena A, Chan C, Hristidis V, et al. PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression. Cell Rep. 2019;27:294-306.e5 pubmed 出版商
Nassa G, Salvati A, Tarallo R, Gigantino V, Alexandrova E, Memoli D, et al. Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells. Sci Adv. 2019;5:eaav5590 pubmed 出版商
Xu B, Li Q, Chen N, Zhu C, Meng Q, Ayyanathan K, et al. The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells. Nucleic Acids Res. 2019;47:2322-2335 pubmed 出版商
Helzer K, Szatkowski Ozers M, Meyer M, Benkusky N, Solodin N, Reese R, et al. The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2. Mol Cell Biol. 2019;39: pubmed 出版商
Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S. Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells. Oncogene. 2019;38:1019-1037 pubmed 出版商
Stratikopoulos E, Kiess N, Szabolcs M, Pegno S, Kakit C, Wu X, et al. Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents. Oncogene. 2019;38:47-59 pubmed 出版商
Hey F, Andreadi C, Noble C, Patel B, Jin H, Kamata T, et al. Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK. Heliyon. 2018;4:e01065 pubmed 出版商
Wang L, Ozark P, Smith E, Zhao Z, Marshall S, Rendleman E, et al. TET2 coactivates gene expression through demethylation of enhancers. Sci Adv. 2018;4:eaau6986 pubmed 出版商
Lopes R, Korkmaz G, Revilla S, van Vliet R, Nagel R, Custers L, et al. CUEDC1 is a primary target of ER? essential for the growth of breast cancer cells. Cancer Lett. 2018;436:87-95 pubmed 出版商
Lei J, Shao J, Zhang J, IGLESIA M, Chan D, Cao J, et al. Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer. Cell Rep. 2018;24:1434-1444.e7 pubmed 出版商
Michalak E, Milevskiy M, Joyce R, Dekkers J, Jamieson P, Pal B, et al. Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids. PLoS Biol. 2018;16:e2004986 pubmed 出版商
Simigdala N, Pancholi S, Ribas R, Folkerd E, Liccardi G, Nikitorowicz Buniak J, et al. Abiraterone shows alternate activity in models of endocrine resistant and sensitive disease. Br J Cancer. 2018;119:313-322 pubmed 出版商
Serandour A, Mohammed H, Miremadi A, Mulder K, Carroll J. TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers. Oncogene. 2018;37:5281-5291 pubmed 出版商
Yoo J, Kang H, Broaddus R, Risinger J, Choi K, Kim T. MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT. BMC Cancer. 2018;18:605 pubmed 出版商
Gala K, Li Q, Sinha A, Razavi P, Dorso M, Sanchez Vega F, et al. KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function. Oncogene. 2018;37:4692-4710 pubmed 出版商
Li W, Xu L, Che X, Li H, Zhang Y, Song N, et al. C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells. BMC Cancer. 2018;18:507 pubmed 出版商
Guertin M, Cullen A, Markowetz F, Holding A. Parallel factor ChIP provides essential internal control for quantitative differential ChIP-seq. Nucleic Acids Res. 2018;46:e75 pubmed 出版商
Ohoka N, Morita Y, Nagai K, Shimokawa K, Ujikawa O, Fujimori I, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018;293:6776-6790 pubmed 出版商
Sugiaman Trapman D, Vitezic M, Jouhilahti E, Mathelier A, Lauter G, Misra S, et al. Characterization of the human RFX transcription factor family by regulatory and target gene analysis. BMC Genomics. 2018;19:181 pubmed 出版商
Jeselsohn R, Bergholz J, Pun M, Cornwell M, Liu W, Nardone A, et al. Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations. Cancer Cell. 2018;33:173-186.e5 pubmed 出版商
Wu Y, Zhang Z, Cenciarini M, Proietti C, Amasino M, Hong T, et al. Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis. Cancer Res. 2018;78:671-684 pubmed 出版商
Campbell T, Castro M, de Oliveira K, Ponder B, Meyer K. ERα Binding by Transcription Factors NFIB and YBX1 Enables FGFR2 Signaling to Modulate Estrogen Responsiveness in Breast Cancer. Cancer Res. 2018;78:410-421 pubmed 出版商
Martin L, Ribas R, Simigdala N, Schuster E, Pancholi S, Tenev T, et al. Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance. Nat Commun. 2017;8:1865 pubmed 出版商
Tarallo R, Giurato G, Bruno G, Ravo M, Rizzo F, Salvati A, et al. The nuclear receptor ER? engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading. Genome Biol. 2017;18:189 pubmed 出版商
Whirledge S, Kisanga E, Taylor R, Cidlowski J. Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells. Endocrinology. 2017;158:4076-4092 pubmed 出版商
Zhao Y, Laws M, Guillen V, Ziegler Y, Min J, Sharma A, et al. Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors. Cancer Res. 2017;77:5602-5613 pubmed 出版商
Finlay Schultz J, Gillen A, Brechbuhl H, Ivie J, Matthews S, Jacobsen B, et al. Breast Cancer Suppression by Progesterone Receptors Is Mediated by Their Modulation of Estrogen Receptors and RNA Polymerase III. Cancer Res. 2017;77:4934-4946 pubmed 出版商
Min J, Guillen V, Sharma A, Zhao Y, Ziegler Y, Gong P, et al. Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells. J Med Chem. 2017;60:6321-6336 pubmed 出版商
Ilsley M, Gillinder K, Magor G, Huang S, Bailey T, Crossley M, et al. Krüppel-like factors compete for promoters and enhancers to fine-tune transcription. Nucleic Acids Res. 2017;45:6572-6588 pubmed 出版商
Jeselsohn R, Cornwell M, Pun M, Buchwalter G, Nguyen M, Bango C, et al. Embryonic transcription factor SOX9 drives breast cancer endocrine resistance. Proc Natl Acad Sci U S A. 2017;114:E4482-E4491 pubmed 出版商
Ferraiuolo R, Tubman J, Sinha I, Hamm C, Porter L. The cyclin-like protein, SPY1, regulates the ER? and ERK1/2 pathways promoting tamoxifen resistance. Oncotarget. 2017;8:23337-23352 pubmed 出版商
Luecke Johansson S, Gralla M, Rundqvist H, Ho J, Johnson R, Gradin K, et al. A Molecular Mechanism To Switch the Aryl Hydrocarbon Receptor from a Transcription Factor to an E3 Ubiquitin Ligase. Mol Cell Biol. 2017;37: pubmed 出版商
Hübner S, Sunny D, Pöhlke C, Ruhnau J, Vogelgesang A, Reich B, et al. Protective Effects of Fetal Zone Steroids Are Comparable to Estradiol in Hyperoxia-Induced Cell Death of Immature Glia. Endocrinology. 2017;158:1419-1435 pubmed 出版商
Padró M, Louie R, Lananna B, Krieg A, Timmerman L, Chan D. Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells. BMC Cancer. 2017;17:203 pubmed 出版商
Stender J, Nwachukwu J, Kastrati I, Kim Y, Strid T, Yakir M, et al. Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells. Mol Cell. 2017;65:1122-1135.e5 pubmed 出版商
Droog M, Nevedomskaya E, Dackus G, Fles R, Kim Y, Hollema H, et al. Estrogen receptor ? wields treatment-specific enhancers between morphologically similar endometrial tumors. Proc Natl Acad Sci U S A. 2017;114:E1316-E1325 pubmed 出版商
Ohoka N, Okuhira K, Ito M, Nagai K, Shibata N, Hattori T, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017;292:4556-4570 pubmed 出版商
Diao Y, Azatyan A, Rahman M, Zhao C, Zhu J, Dahlman Wright K, et al. Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells. Oncotarget. 2016;7:71580-71593 pubmed 出版商
Bouilly J, Beau I, Barraud S, Bernard V, Azibi K, Fagart J, et al. Identification of Multiple Gene Mutations Accounts for a new Genetic Architecture of Primary Ovarian Insufficiency. J Clin Endocrinol Metab. 2016;101:4541-4550 pubmed
Ladd B, Mazzola A, Bihani T, Lai Z, BRADFORD J, Collins M, et al. Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations. Oncotarget. 2016;7:54120-54136 pubmed 出版商
Ronghe A, Chatterjee A, Bhat N, Padhye S, Bhat H. Tamoxifen synergizes with 4-(E)-{(4-hydroxyphenylimino)-methylbenzene, 1,2-diol} and 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, novel azaresveratrol analogs, in inhibiting the proliferation of breast cancer cells. Oncotarget. 2016;7:51747-51762 pubmed 出版商
Neguembor M, Xynos A, Onorati M, Caccia R, Bortolanza S, Godio C, et al. FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis. J Mol Cell Biol. 2013;5:294-307 pubmed 出版商
公司信息
圣克鲁斯生物技术
上海浦东新区建业路315号2号楼1-6号
asia@scbio.cn
http://www.scbt.com/zh/
800-820-8626
公司总部: 美国
圣克鲁斯生物技术公司拥有最高的质量承诺和客户服务。