产品简要
公司名称 :
圣克鲁斯生物技术
产品类型 :
抗体
产品名称 :
Cdk5(J-3)抗体
目录 :
sc-6247
规格 :
200微克/毫升
价格 :
279美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
J-3
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 24
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 ev2
Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Kurbatskaya K, Phillips E, Croft C, Dentoni G, Hughes M, Wade M, et al. Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain. Acta Neuropathol Commun. 2016;4:34 pubmed 出版商
  • 免疫沉淀; 大鼠
  • 免疫印迹; 大鼠
Kim B, Serebreni L, Fallica J, Hamdan O, Wang L, Johnston L, et al. Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia. PLoS ONE. 2015;10:e0124189 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Xie Q, Wu Q, Horbinski C, Flavahan W, Yang K, Zhou W, et al. Mitochondrial control by DRP1 in brain tumor initiating cells. Nat Neurosci. 2015;18:501-10 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Tripathi B, Qian X, Mertins P, Wang D, Papageorge A, Carr S, et al. CDK5 is a major regulator of the tumor suppressor DLC1. J Cell Biol. 2014;207:627-42 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 4
Nishimura Y, Shikanai M, Hoshino M, Ohshima T, Nabeshima Y, Mizutani K, et al. Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons. Development. 2014;141:3540-50 pubmed 出版商
  • 免疫沉淀; 人类; 图 1
  • 免疫印迹; 人类; 图 1
Tripathi B, Lowy D, Zelenka P. The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens. Exp Cell Res. 2015;330:186-98 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
  • 免疫印迹; 大鼠
Absalon S, Kochanek D, Raghavan V, Krichevsky A. MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci. 2013;33:14645-59 pubmed 出版商
Ko Y, Kim C, Lee J, Kim D, Kim Y, Yun N, et al. Site-specific phosphorylation of Fbxw7 by Cdk5/p25 and its resulting decreased stability are linked to glutamate-induced excitotoxicity. Cell Death Dis. 2019;10:579 pubmed 出版商
Salissou M, Mahaman Y, Zhu F, Huang F, Wang Y, Xu Z, et al. Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats. Aging (Albany NY). 2018;10:3229-3248 pubmed 出版商
Lee J, Ko Y, Chung Y, Yun N, Kim M, Kim K, et al. The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons. Sci Rep. 2018;8:13676 pubmed 出版商
Cho B, Cho H, Kim H, Jeong J, Park S, Hwang E, et al. CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation. Exp Mol Med. 2014;46:e105 pubmed 出版商
Zhong B, Wang T, Lun X, Zhang J, Zheng S, Yang W, et al. Contribution of nestin positive esophageal squamous cancer cells on malignant proliferation, apoptosis, and poor prognosis. Cancer Cell Int. 2014;14:57 pubmed 出版商
Oaks A, Frankfurt M, Finkelstein D, Sidhu A. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS ONE. 2013;8:e60378 pubmed 出版商
Cantrup R, Sathanantham K, Rushlow W, Rajakumar N. Chronic hyperdopaminergic activity of schizophrenia is associated with increased ?FosB levels and cdk-5 signaling in the nucleus accumbens. Neuroscience. 2012;222:124-35 pubmed 出版商
Busso C, Wedgeworth C, Izumi T. Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5. Nucleic Acids Res. 2011;39:8017-28 pubmed 出版商
Corbel C, Wang Q, Bousserouel H, Hamdi A, Zhang B, Lozach O, et al. First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors. Biotechnol J. 2011;6:860-70 pubmed 出版商
Poore C, Sundaram J, Pareek T, Fu A, Amin N, Mohamed N, et al. Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity. J Neurosci. 2010;30:8457-67 pubmed 出版商
Tripathi B, Zelenka P. Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP. Mol Cell Biol. 2009;29:6488-99 pubmed 出版商
Chen H, Wang L, D Mello S. A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase. Eur J Neurosci. 2008;28:2003-16 pubmed 出版商
Alvira D, Tajes M, Verdaguer E, Acuna Castroviejo D, Folch J, Camins A, et al. Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease. J Pineal Res. 2006;40:251-8 pubmed
Verdaguer E, Jorda E, Alvira D, Jiménez A, Canudas A, Folch J, et al. Inhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neurons. J Mol Neurosci. 2005;26:71-84 pubmed
Johnson K, Liu L, Majdzadeh N, Chavez C, Chin P, Morrison B, et al. Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: identification of 3' substituted indolones as a scaffold for the development of neuroprotective drugs. J Neurochem. 2005;93:538-48 pubmed
Lu G, Seta K, Millhorn D. Novel role for cyclin-dependent kinase 2 in neuregulin-induced acetylcholine receptor epsilon subunit expression in differentiated myotubes. J Biol Chem. 2005;280:21731-8 pubmed
产品信息
产品名称 :
Cdk5(J-3)抗体
基因名称 :
CDK5
规格 :
200微克/毫升
价格 :
279美元
目录号 :
sc-6247
类型 :
单克隆
宿主 :
小鼠单克隆
抗原 :
Cdk5
反应物种 :
m, r, h
应用 :
免疫印迹, 免疫沉淀, IF, 酶联免疫吸附测定
表位 :
FL(人类)
交货时间 :
在下午三点前下订单在美国的次日送达;从我们美国的办公室通过国际航运两日后送达;在我们的欧洲办事处下订单次日运抵欧洲客户
更多信息或购买 :
公司信息
圣克鲁斯生物技术
上海浦东新区建业路315号2号楼1-6号
asia@scbio.cn
http://www.scbt.com/zh/
800-820-8626
公司总部: 美国
圣克鲁斯生物技术公司拥有最高的质量承诺和客户服务。