Siu M, Jiang Y, Wang J, Leung T, Ngu S, Cheung A, et al. PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via α5β1 integrin and JNK/IL-8 signaling. Oncogenesis. 2020;9:24 pubmed 出版商

Shami Shah A, Batrouni A, Kim D, Punyala A, Cao W, Han C, et al. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. Cell Rep. 2019;27:2157-2170.e8 pubmed 出版商

Liu Q, Liu C, Jiang L, Li M, Long T, He W, et al. α7 Nicotinic acetylcholine receptor-mediated anti-inflammatory effect in a chronic migraine rat model via the attenuation of glial cell activation. J Pain Res. 2018;11:1129-1140 pubmed 出版商

Wu J, Liu Y, Liang J, Huang Q, Dou Y, Nie J, et al. Protective role of ?-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. Phytomedicine. 2018;39:111-118 pubmed 出版商

Bagarolli R, Tobar N, Oliveira A, Araújo T, Carvalho B, Rocha G, et al. Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice. J Nutr Biochem. 2017;50:16-25 pubmed 出版商

Mamo T, Wittern A, Kleppa M, Bohnenpoll T, Weiss A, Kispert A. BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter. Hum Mol Genet. 2017;26:3553-3563 pubmed 出版商

Kurapati S, Sadaoka T, Rajbhandari L, Jagdish B, Shukla P, Ali M, et al. Role of the JNK Pathway in Varicella-Zoster Virus Lytic Infection and Reactivation. J Virol. 2017;91: pubmed 出版商

Biggi S, Buccarello L, Sclip A, Lippiello P, Tonna N, Rumio C, et al. Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase. Neural Plast. 2017;2017:6468356 pubmed 出版商

Retzlaff J, Thamm K, Ghosh C, Ziegler W, Haller H, Parikh S, et al. Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis. Sci Rep. 2017;7:44113 pubmed 出版商

de Oliveira R, de Campos Castilho G, da Cunha A, Miyajima F, de Oliveira Martins D. Dilodendron bipinnatum Radlk. inhibits pro-inflammatory mediators through the induction of MKP-1 and the down-regulation of MAPKp38/JNK/NF-?B pathways and COX-2 in LPS-activated RAW 264.7 cells. J Ethnopharmacol. 2017;202:127-137 pubmed 出版商

Zhong W, Wang X, Pan B, Li F, Kuang L, Su Z. Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways. Oncol Lett. 2016;12:2894-2899 pubmed

Wu Y, Ren D, Chen G. Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis. J Immunol. 2016;197:3336-3347 pubmed

Lee J, Jung H, Han Y, Yoon Y, Yun C, Sun H, et al. Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells. Mol Med Rep. 2016;14:3777-84 pubmed 出版商

El Jamal S, Taylor E, Abd Elmageed Z, Alamodi A, Selimovic D, Alkhateeb A, et al. Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways. Cell Div. 2016;11:11 pubmed 出版商

Ciaraldi T, Ryan A, Mudaliar S, Henry R. Altered Myokine Secretion Is an Intrinsic Property of Skeletal Muscle in Type 2 Diabetes. PLoS ONE. 2016;11:e0158209 pubmed 出版商

Botchlett R, Li H, Guo X, Qi T, Zhao J, Zheng J, et al. Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells. Sci Rep. 2016;6:28963 pubmed 出版商

Zhang C, Li L, Zhao B, Jiao A, Li X, Sun N, et al. Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling. Int J Endocrinol. 2016;2016:4513051 pubmed 出版商

Wu Y, Lan C, Ren D, Chen G. Induction of Siglec-1 by Endotoxin Tolerance Suppresses the Innate Immune Response by Promoting TGF-?1 Production. J Biol Chem. 2016;291:12370-82 pubmed 出版商

Choi H, Kim M, Choi Y, Shin Y, Cho S, Ko S. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med. 2016;16:122 pubmed 出版商

Liu S, Wu C, Huang K, Wang C, Guan S, Chen L, et al. C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease. Oncotarget. 2016;7:21900-12 pubmed 出版商

Choi J, Kim I, Kim Y, Lee M, Nam T. Pyropia yezoensis glycoprotein regulates antioxidant status and prevents hepatotoxicity in a rat model of D-galactosamine/lipopolysaccharide-induced acute liver failure. Mol Med Rep. 2016;13:3110-4 pubmed 出版商

Rubattu S, Di Castro S, Schulz H, Geurts A, Cotugno M, Bianchi F, et al. Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. J Am Heart Assoc. 2016;5: pubmed 出版商

Wu T, Li Y, Liu B, Zhang S, Wu L, Zhu X, et al. Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway. PLoS ONE. 2016;11:e0149361 pubmed 出版商

Yang Q, Sun G, Cao Z, Yin H, Qi Q, Wang J, et al. The expression of NLRX1 in C57BL/6 mice cochlear hair cells: Possible relation to aging- and neomycin-induced deafness. Neurosci Lett. 2016;616:138-46 pubmed 出版商

Daniele S, Zappelli E, Martini C. Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes. J Neuroinflammation. 2015;12:225 pubmed 出版商

Dinh C, Szabo A, Yu Y, Camer D, Wang H, Huang X. Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice. ScientificWorldJournal. 2015;2015:549352 pubmed 出版商

Giri K, Pabelick C, Mukherjee P, Prakash Y. Hepatoma derived growth factor (HDGF) dynamics in ovarian cancer cells. Apoptosis. 2016;21:329-39 pubmed 出版商

El Khattouti A, Selimovic D, Hannig M, Taylor E, Abd Elmageed Z, Hassan S, et al. Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-κB inhibition. J Cell Mol Med. 2016;20:266-86 pubmed 出版商

Wong T, Lin S, Leung L. The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells. PLoS ONE. 2015;10:e0135637 pubmed 出版商

Wu M, Lee W, Hua K, Kuo M, Lin M. Macrophage Infiltration Induces Gastric Cancer Invasiveness by Activating the β-Catenin Pathway. PLoS ONE. 2015;10:e0134122 pubmed 出版商

Gorojod R, Alaimo A, Porte Alcon S, Pomilio C, Saravia F, Kotler M. The autophagic- lysosomal pathway determines the fate of glial cells under manganese- induced oxidative stress conditions. Free Radic Biol Med. 2015;87:237-51 pubmed 出版商

Hao W, Yuan X, Yu L, Gao C, Sun X, Wang D, et al. Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. Sci Rep. 2015;5:10336 pubmed 出版商

Wong T, Lin S, Leung L. The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68. Br J Nutr. 2015;113:1844-52 pubmed 出版商

Daniele S, Da Pozzo E, Zappelli E, Martini C. Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-?B, p38 and JNK. Cell Signal. 2015;27:1609-29 pubmed 出版商

Benzina S, Pitaval A, Lemercier C, Lustremant C, Frouin V, Wu N, et al. A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. Cell Mol Life Sci. 2015;72:3559-73 pubmed 出版商

Pan J, Li H, Zhang B, Xiong R, Zhang Y, Kang W, et al. Small peptide inhibitor of JNK3 protects dopaminergic neurons from MPTP induced injury via inhibiting the ASK1-JNK3 signaling pathway. PLoS ONE. 2015;10:e0119204 pubmed 出版商

Roost M, van Iperen L, De Melo Bernardo A, Mummery C, Carlotti F, de Koning E, et al. Lymphangiogenesis and angiogenesis during human fetal pancreas development. Vasc Cell. 2014;6:22 pubmed 出版商

Seaberg B, Henslee G, Wang S, Paez Colasante X, Landreth G, Rimer M. Muscle-derived extracellular signal-regulated kinases 1 and 2 are required for the maintenance of adult myofibers and their neuromuscular junctions. Mol Cell Biol. 2015;35:1238-53 pubmed 出版商

Mello C, Ramos L, Gimenes A, Andrade T, Oliani S, Gil C. Immunomodulatory effects of galectin-1 on an IgE-mediated allergic conjunctivitis model. Invest Ophthalmol Vis Sci. 2015;56:693-704 pubmed 出版商

Passos E, Pereira C, Gonçalves I, Rocha Rodrigues S, Silva N, Guimarães J, et al. Role of physical exercise on hepatic insulin, glucocorticoid and inflammatory signaling pathways in an animal model of non-alcoholic steatohepatitis. Life Sci. 2015;123:51-60 pubmed 出版商

El Khattouti A, Sheehan N, Monico J, Drummond H, Haikel Y, Brodell R, et al. CD133⁺ melanoma subpopulation acquired resistance to caffeic acid phenethyl ester-induced apoptosis is attributed to the elevated expression of ABCB5: significance for melanoma treatment. Cancer Lett. 2015;357:83-104 pubmed 出版商

Ji X, Lu H, Zhou Q, Luo K. LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. elife. 2014;3:e02907 pubmed 出版商

Chondrogiannis G, Kastamoulas M, Kanavaros P, Vartholomatos G, Bai M, Baltogiannis D, et al. Cytokine effects on cell viability and death of prostate carcinoma cells. Biomed Res Int. 2014;2014:536049 pubmed 出版商

Yang Q, Hao J, Chen M, Li G. Dermatopontin is a novel regulator of the CdCl2-induced decrease in claudin-11 expression. Toxicol In Vitro. 2014;28:1158-64 pubmed 出版商

Wei X, Zhang F, Wang K, Zhang Q, Rong L. Assembly of the FKBP51-PHLPP2-AKT signaling complex in cerebral ischemia/reperfusion injury in rats. Brain Res. 2014;1566:60-8 pubmed 出版商

Valente A, Irimpen A, Siebenlist U, Chandrasekar B. OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators. Free Radic Biol Med. 2014;70:117-28 pubmed 出版商

Jin Y, Wi H, Choi M, Hong S, Bae Y. Regulation of anti-inflammatory cytokines IL-10 and TGF-? in mouse dendritic cells through treatment with Clonorchis sinensis crude antigen. Exp Mol Med. 2014;46:e74 pubmed 出版商

Gámez M, Calvo M, Selgas M, García M, Erler K, Böhm V, et al. Effect of E-beam treatment on the chemistry and on the antioxidant activity of lycopene from dry tomato peel and tomato powder. J Agric Food Chem. 2014;62:1557-63 pubmed 出版商

Megison M, Gillory L, Stewart J, Nabers H, Mrozcek Musulman E, Beierle E. FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors. Mol Cancer Res. 2014;12:514-26 pubmed 出版商

Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, et al. PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-?B. J Hepatol. 2014;60:306-12 pubmed 出版商

Cheng X, Chapple S, Patel B, Puszyk W, Sugden D, Yin X, et al. Gestational diabetes mellitus impairs Nrf2-mediated adaptive antioxidant defenses and redox signaling in fetal endothelial cells in utero. Diabetes. 2013;62:4088-97 pubmed 出版商

Yuan F, Xu Z, Yang M, Wei Q, Zhang Y, Yu J, et al. Overexpressed DNA polymerase iota regulated by JNK/c-Jun contributes to hypermutagenesis in bladder cancer. PLoS ONE. 2013;8:e69317 pubmed 出版商

Karna K, Choi B, You J, Shin Y, Cui W, Lee S, et al. The ameliorative effect of monotropein, astragalin, and spiraeoside on oxidative stress, endoplasmic reticulum stress, and mitochondrial signaling pathway in varicocelized rats. BMC Complement Altern Med. 2019;19:333 pubmed 出版商

Sugano E, Tabata K, Takezawa T, Shiraiwa R, Muraoka H, Metoki T, et al. N-Methyl-N-Nitrosourea-Induced Photoreceptor Degeneration Is Inhibited by Nicotinamide via the Blockade of Upstream Events before the Phosphorylation of Signalling Proteins. Biomed Res Int. 2019;2019:3238719 pubmed 出版商

Mohan A, Dean K, Isogai T, Kasitinon S, Murali V, Roudot P, et al. Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells. Dev Cell. 2019;49:444-460.e9 pubmed 出版商

Ibrahim D, Ko J, Iwata W, Okumichi H, Kiuchi Y. An in vitro study of scarring formation mediated by human Tenon fibroblasts: Effect of Y-27632, a Rho kinase inhibitor. Cell Biochem Funct. 2019;37:113-124 pubmed 出版商

Ogiwara H, Takahashi K, Sasaki M, Kuroda T, Yoshida H, Watanabe R, et al. Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers. Cancer Cell. 2019;35:177-190.e8 pubmed 出版商

Wang Q, He Q, Chen Y, Shao W, Yuan C, Wang Y. JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss. J Neuroinflammation. 2018;15:184 pubmed 出版商

Taga M, Mouton Liger F, Sadoune M, Gourmaud S, Norman J, Tible M, et al. PKR modulates abnormal brain signaling in experimental obesity. PLoS ONE. 2018;13:e0196983 pubmed 出版商

Gibbs K, Kalmar B, Rhymes E, Fellows A, Ahmed M, Whiting P, et al. Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS. Cell Death Dis. 2018;9:596 pubmed 出版商

Li X, Shang E, Dong Q, Li Y, Zhang J, Xu S, et al. Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway. J Biol Chem. 2018;293:7423-7436 pubmed 出版商

Sung K, Ferrari L, Yang W, Chung C, Zhao X, Gu Y, et al. Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception. J Neurosci. 2018;38:3394-3413 pubmed 出版商

Karrys A, Rady I, Chamcheu R, Sabir M, Mallick S, Chamcheu J, et al. Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis. Nutrients. 2018;10: pubmed 出版商

Choi J, Kim K, Koh E, Lee B. Gelidium elegans Extract Ameliorates Type 2 Diabetes via Regulation of MAPK and PI3K/Akt Signaling. Nutrients. 2018;10: pubmed 出版商

Chen J, Kuo C, Pai P, Ho T, Chen T, Tsai F, et al. Mitochondrial ROS-induced ERK1/2 activation and HSF2-mediated AT1 R upregulation are required for doxorubicin-induced cardiotoxicity. J Cell Physiol. 2018;233:463-475 pubmed 出版商

Tsuboi M, Taniuchi K, Shimizu T, Saito M, Saibara T. The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. J Biol Chem. 2017;292:17681-17702 pubmed 出版商

Komiya C, Tanaka M, Tsuchiya K, Shimazu N, Mori K, Furuke S, et al. Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis. Sci Rep. 2017;7:44754 pubmed 出版商

Kim Y, Tian C, Kim J, Shin B, Choo O, Kim Y, et al. Autophagic flux, a possible mechanism for delayed gentamicin-induced ototoxicity. Sci Rep. 2017;7:41356 pubmed 出版商

Bai Y, Zhang Y, Hua J, Yang X, Zhang X, Duan M, et al. Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse. Sci Rep. 2016;6:35642 pubmed 出版商

Chouhan S, Singh S, Athavale D, Ramteke P, Pandey V, Joseph J, et al. Glucose induced activation of canonical Wnt signaling pathway in hepatocellular carcinoma is regulated by DKK4. Sci Rep. 2016;6:27558 pubmed 出版商

Choi H, Lee K, Kim M, Lee K, Shin Y, Cho S, et al. DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis. Oncotarget. 2016;7:21775-85 pubmed 出版商

Liu M, Park J, Wu X, Li Y, Tran Q, Mun K, et al. Shen-Kang protects 5/6 nephrectomized rats against renal injury by reducing oxidative stress through the MAPK signaling pathways. Int J Mol Med. 2015;36:975-84 pubmed 出版商

Haarmann A, Nowak E, Deiß A, van der Pol S, Monoranu C, Kooij G, et al. Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin α-4-transduced outside-in signalling. Acta Neuropathol. 2015;129:639-52 pubmed 出版商

Portovedo M, Ignacio Souza L, Bombassaro B, Coope A, Reginato A, Razolli D, et al. Saturated fatty acids modulate autophagy's proteins in the hypothalamus. PLoS ONE. 2015;10:e0119850 pubmed 出版商

Wang L, Luo H, Chen X, Jiang Y, Huang Q. Functional characterization of S100A8 and S100A9 in altering monolayer permeability of human umbilical endothelial cells. PLoS ONE. 2014;9:e90472 pubmed 出版商

Carpenter R, Paw I, Dewhirst M, Lo H. Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells. Oncogene. 2015;34:546-57 pubmed 出版商

Jia G, Kong R, Ma Z, Han B, Wang Y, Pan S, et al. The activation of c-Jun NH?-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells. J Exp Clin Cancer Res. 2014;33:8 pubmed 出版商

Wang L, Cheng X, Li H, Qiu F, Yang N, Wang B, et al. Quercetin reduces oxidative stress and inhibits activation of c?Jun N?terminal kinase/activator protein?1 signaling in an experimental mouse model of abdominal aortic aneurysm. Mol Med Rep. 2014;9:435-42 pubmed 出版商

Carneiro A, Iaciura B, Nohara L, Lopes C, Veas E, Mariano V, et al. Lysophosphatidylcholine triggers TLR2- and TLR4-mediated signaling pathways but counteracts LPS-induced NO synthesis in peritoneal macrophages by inhibiting NF-?B translocation and MAPK/ERK phosphorylation. PLoS ONE. 2013;8:e76233 pubmed 出版商

Goitre L, De Luca E, Braggion S, Trapani E, Guglielmotto M, Biasi F, et al. KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun. Free Radic Biol Med. 2014;68:134-47 pubmed 出版商

Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, et al. Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PLoS ONE. 2013;8:e73859 pubmed 出版商

Tan Z, Qian X, Jiang R, Liu Q, Wang Y, Chen C, et al. IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. J Immunol. 2013;191:1835-44 pubmed 出版商

Zhang J, Gao Z, Ye J. Phosphorylation and degradation of S6K1 (p70S6K1) in response to persistent JNK1 Activation. Biochim Biophys Acta. 2013;1832:1980-8 pubmed 出版商

Munoz Alonso M, Alvarez E, Guillén Navarro M, Pollan M, Aviles P, Galmarini C, et al. c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity. Mar Drugs. 2013;11:1677-92 pubmed 出版商

Callero M, Luzzani G, De Dios D, Bradshaw T, Perez A. Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer. J Cell Biochem. 2013;114:2392-404 pubmed 出版商

Lopez S, Jaramillo S, Varela L, Ortega A, Bermudez B, Abia R, et al. p38 MAPK protects human monocytes from postprandial triglyceride-rich lipoprotein-induced toxicity. J Nutr. 2013;143:620-6 pubmed 出版商

Werwein E, Dzuganova M, Usadel C, Klempnauer K. B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress. Cell Death Dis. 2013;4:e511 pubmed 出版商

Kastamoulas M, Chondrogiannis G, Kanavaros P, Vartholomatos G, Bai M, Briasoulis E, et al. Cytokine effects on cell survival and death of A549 lung carcinoma cells. Cytokine. 2013;61:816-25 pubmed 出版商

Lu J, Yu J, Lim S, Son Y, Kim D, Lee S, et al. Cellular mechanisms of the cytotoxic effects of the zearalenone metabolites ?-zearalenol and ?-zearalenol on RAW264.7 macrophages. Toxicol In Vitro. 2013;27:1007-17 pubmed 出版商

Cheng T, Zhang L, Fu X, Wang W, Xu H, Song H, et al. The potential protective effects of calcitonin involved in coordinating chondrocyte response, extracellular matrix, and subchondral trabecular bone in experimental osteoarthritis. Connect Tissue Res. 2013;54:139-46 pubmed 出版商

Martínez Palacián A, del Castillo G, Suárez Causado A, García Álvaro M, de Morena Frutos D, Fernandez M, et al. Mouse hepatic oval cells require Met-dependent PI3K to impair TGF-?-induced oxidative stress and apoptosis. PLoS ONE. 2013;8:e53108 pubmed 出版商

Semlali A, Witoled C, Alanazi M, Rouabhia M. Whole cigarette smoke increased the expression of TLRs, HBDs, and proinflammory cytokines by human gingival epithelial cells through different signaling pathways. PLoS ONE. 2012;7:e52614 pubmed 出版商

Muller L, Catalano A, Simone R, Cittadini A, Fröhlich K, Böhm V, et al. Antioxidant capacity of tomato seed oil in solution and its redox properties in cultured macrophages. J Agric Food Chem. 2013;61:346-54 pubmed 出版商

Liu D, Yuan F, Hu S, Diao F, Wu Y, Zong Y, et al. Endogenous nitric oxide induces activation of apoptosis signal-regulating kinase 1 via S-nitrosylation in rat hippocampus during cerebral ischemia-reperfusion. Neuroscience. 2013;229:36-48 pubmed 出版商

Sun Y, Zou M, Hu C, Qin Y, Song X, Lu N, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food Chem Toxicol. 2013;51:53-60 pubmed 出版商

Palmieri D, Perego P, Palombo D. Apigenin inhibits the TNF?-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement. Mol Cell Biochem. 2012;371:129-36 pubmed 出版商

Tran T, Shi X, Zaia J, Ai X. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem. 2012;287:32651-64 pubmed

Ha S, Park H, Eom H, Kim Y, Choi I. Narirutin fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-?B and MAPKs activation. Food Chem Toxicol. 2012;50:3498-504 pubmed 出版商

Cao M, Tong Y, Lv Q, Chen X, Long Y, Jiang L, et al. PPAR? Activation Rescues Pancreatic ?-Cell Line INS-1E from Palmitate-Induced Endoplasmic Reticulum Stress through Enhanced Fatty Acid Oxidation. PPAR Res. 2012;2012:680684 pubmed 出版商

Xu X, Kriegel A, Liu Y, Usa K, Mladinov D, Liu H, et al. Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. Kidney Int. 2012;82:1167-75 pubmed 出版商

Xiao J, Ferner A, Wong A, Denham M, Kilpatrick T, Murray S. Extracellular signal-regulated kinase 1/2 signaling promotes oligodendrocyte myelination in vitro. J Neurochem. 2012;122:1167-80 pubmed 出版商

Gonzalo S, Grasa L, Hernández L, Arruebo M, Plaza M, Murillo M. Mitogen activated protein kinases blockade improves lipopolysaccharide-induced ileal motor disturbances. Rev Esp Enferm Dig. 2012;104:305-9 pubmed

Engelmann J, Vitto M, Cesconetto P, Silveira P, Possato J, Pinho R, et al. Pulsed ultrasound and dimethylsulfoxide gel treatment reduces the expression of pro-inflammatory molecules in an animal model of muscle injury. Ultrasound Med Biol. 2012;38:1470-5 pubmed 出版商

Li W, Man X, Li C, Chen J, Zhou J, Cai S, et al. VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK. Exp Cell Res. 2012;318:1633-40 pubmed 出版商

Stefani C, de Oliveira R, Silveira A, Ferraz L, Ribeiro M, Gambero A, et al. Expression of Toll-like receptors in enterocromaffin-like cells and their function in histamine release. Dig Dis Sci. 2012;57:2270-7 pubmed 出版商

Sheng L, Zhou Y, Chen Z, Ren D, Cho K, Jiang L, et al. NF-?B–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nat Med. 2012;18:943-9 pubmed 出版商

Wi H, Jin Y, Choi M, Hong S, Bae Y. Predominance of IL-10 and TGF-? production from the mouse macrophage cell line, RAW264.7, in response to crude antigens from Clonorchis sinensis. Cytokine. 2012;59:237-44 pubmed 出版商

Xiang J, Chen D, Yang L. Effect of PANDER in ?TC6-cell lipoapoptosis and the protective role of exendin-4. Biochem Biophys Res Commun. 2012;421:701-6 pubmed 出版商

Lv Q, Liu Y, Han D, Xu J, Zong Y, Wang Y, et al. Neuroprotection of GluK1 kainate receptor agonist ATPA against ischemic neuronal injury through inhibiting GluK2 kainate receptor-JNK3 pathway via GABA(A) receptors. Brain Res. 2012;1456:1-13 pubmed 出版商

Lin L, Pang W, Chen K, Wang F, Gengler J, Sun Y, et al. Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of inflammatory cytokine gene expression and ROS production. Am J Physiol Endocrinol Metab. 2012;302:E1550-9 pubmed 出版商

Di J, Li C, Yu H, Zheng J, Zhang G. nNOS downregulation attenuates neuronal apoptosis by inhibiting nNOS-GluR6 interaction and GluR6 nitrosylation in cerebral ischemic reperfusion. Biochem Biophys Res Commun. 2012;420:594-9 pubmed 出版商

Vazquez Prieto M, Bettaieb A, Haj F, Fraga C, Oteiza P. (-)-Epicatechin prevents TNF?-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes. Arch Biochem Biophys. 2012;527:113-8 pubmed 出版商

Planchard D, Camara Clayette V, Dorvault N, Soria J, Fouret P. p38 Mitogen-activated protein kinase signaling, ERCC1 expression, and viability of lung cancer cells from never or light smoker patients. Cancer. 2012;118:5015-25 pubmed 出版商

Qi D, Liu H, Niu J, Fan X, Wen X, Du Y, et al. Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia. J Neurol Sci. 2012;317:123-9 pubmed 出版商

Palmieri D, Aliakbarian B, Casazza A, Ferrari N, Spinella G, Pane B, et al. Effects of polyphenol extract from olive pomace on anoxia-induced endothelial dysfunction. Microvasc Res. 2012;83:281-9 pubmed 出版商

Hu C, Zou M, Zhao L, Lu N, Sun Y, Gou S, et al. E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells. Toxicol Lett. 2012;210:78-86 pubmed 出版商

Kim J, Lee E, Jeon K, Choi H, Lim H, Kim S, et al. Role of BI-1 (TEGT)-mediated ERK1/2 activation in mitochondria-mediated apoptosis and splenomegaly in BI-1 transgenic mice. Biochim Biophys Acta. 2012;1823:876-88 pubmed 出版商

Osborne N, Ji D, Majid A, Del Soldata P, Sparatore A. Glutamate oxidative injury to RGC-5 cells in culture is necrostatin sensitive and blunted by a hydrogen sulfide (H2S)-releasing derivative of aspirin (ACS14). Neurochem Int. 2012;60:365-78 pubmed 出版商

Ndour P, Brocqueville G, Ouk T, Goormachtigh G, Morales O, Mougel A, et al. Inhibition of latent membrane protein 1 impairs the growth and tumorigenesis of latency II Epstein-Barr virus-transformed T cells. J Virol. 2012;86:3934-43 pubmed 出版商

Hutton E, Carty L, Laura M, Houlden H, Lunn M, Brandner S, et al. c-Jun expression in human neuropathies: a pilot study. J Peripher Nerv Syst. 2011;16:295-303 pubmed 出版商

Hu S, Ye J, Zong Y, Sun C, Liu D, Wu Y, et al. S-nitrosylation of mixed lineage kinase 3 contributes to its activation after cerebral ischemia. J Biol Chem. 2012;287:2364-77 pubmed 出版商

Qi S, Zhao H, Gong J, Sun F, Yue J, Guan Q, et al. Neuroprotection of paclitaxel against cerebral ischemia/reperfusion-induced brain injury through JNK3 signaling pathway. J Recept Signal Transduct Res. 2011;31:402-7 pubmed 出版商

Guan W, Sha J, Chen X, Xing Y, Yan J, Wang Z. S-Nitrosylation of mitogen activated protein kinase phosphatase-1 suppresses radiation-induced apoptosis. Cancer Lett. 2012;314:137-46 pubmed 出版商

Chen K, Jin P, He H, Xie Y, Xie X, Mo Z. Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c. J Biomed Sci. 2011;18:57 pubmed 出版商

Coso S, Zeng Y, Sooraj D, Williams E. Conserved signaling through vascular endothelial growth (VEGF) receptor family members in murine lymphatic endothelial cells. Exp Cell Res. 2011;317:2397-407 pubmed 出版商

Yu J, Zheng Z, Son Y, Shi X, Jang Y, Lee J. Mycotoxin zearalenone induces AIF- and ROS-mediated cell death through p53- and MAPK-dependent signaling pathways in RAW264.7 macrophages. Toxicol In Vitro. 2011;25:1654-63 pubmed 出版商

Sokolowski K, Falluel Morel A, Zhou X, Dicicco Bloom E. Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures. Neurotoxicology. 2011;32:535-44 pubmed 出版商

Lee S, Son Y, Kook S, Choi K, Lee J. Ascorbic acid increases the activity and synthesis of tyrosinase in B16F10 cells through activation of p38 mitogen-activated protein kinase. Arch Dermatol Res. 2011;303:669-78 pubmed 出版商

Ibrahim A, Mbodji K, Hassan A, Aziz M, Boukhettala N, Coeffier M, et al. Anti-inflammatory and anti-angiogenic effect of long chain n-3 polyunsaturated fatty acids in intestinal microvascular endothelium. Clin Nutr. 2011;30:678-87 pubmed 出版商

Ploia C, Antoniou X, Sclip A, Grande V, Cardinetti D, Colombo A, et al. JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models. J Alzheimers Dis. 2011;26:315-29 pubmed 出版商

Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis R, Ye J. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem. 2011;286:22227-34 pubmed 出版商

Ju K, Lim J, Kim K, Kim H. Potential role of NADPH oxidase-mediated activation of Jak2/Stat3 and mitogen-activated protein kinases and expression of TGF-?1 in the pathophysiology of acute pancreatitis. Inflamm Res. 2011;60:791-800 pubmed 出版商

Li C, Fan S, Owonikoko T, Khuri F, Sun S, Li R. Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway. Oncogene. 2011;30:3802-12 pubmed 出版商

Leonelli M, Martins D, Britto L. TRPV1 receptors modulate retinal development. Int J Dev Neurosci. 2011;29:405-13 pubmed 出版商

Mandalari G, Bisignano C, Genovese T, Mazzon E, Wickham M, Paterniti I, et al. Natural almond skin reduced oxidative stress and inflammation in an experimental model of inflammatory bowel disease. Int Immunopharmacol. 2011;11:915-24 pubmed 出版商

Svensson C, Part K, Künnis Beres K, Kaldmäe M, Fernaeus S, Land T. Pro-survival effects of JNK and p38 MAPK pathways in LPS-induced activation of BV-2 cells. Biochem Biophys Res Commun. 2011;406:488-92 pubmed 出版商

Ji D, Kamalden T, Del Olmo Aguado S, Osborne N. Light- and sodium azide-induced death of RGC-5 cells in culture occurs via different mechanisms. Apoptosis. 2011;16:425-37 pubmed 出版商

Somvanshi R, War S, Chaudhari N, Qiu X, Kumar U. Receptor specific crosstalk and modulation of signaling upon heterodimerization between ?1-adrenergic receptor and somatostatin receptor-5. Cell Signal. 2011;23:794-811 pubmed 出版商

Castro J, Ribo M, Navarro S, Nogués M, Vilanova M, Benito A. A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation. BMC Cancer. 2011;11:9 pubmed 出版商

Gonzalo S, Grasa L, Arruebo M, Plaza M, Murillo M. Lipopolysaccharide-induced intestinal motility disturbances are mediated by c-Jun NH2-terminal kinases. Dig Liver Dis. 2011;43:277-85 pubmed 出版商

Wang Y, Kuo J, Lee S, Liu J, Hsieh Y, Shih Y, et al. Cobra CRISP functions as an inflammatory modulator via a novel Zn2+- and heparan sulfate-dependent transcriptional regulation of endothelial cell adhesion molecules. J Biol Chem. 2010;285:37872-83 pubmed 出版商

Li Y, Chen J, Wu C, Wang L, Lu M, Chen X. Hepatitis B virus/hepatitis C virus upregulate angiopoietin-2 expression through mitogen-activated protein kinase pathway. Hepatol Res. 2010;40:1022-33 pubmed 出版商

Burkhard K, Shapiro P. Use of inhibitors in the study of MAP kinases. Methods Mol Biol. 2010;661:107-22 pubmed 出版商

Xu B, Yang L, Lye R, Hinton B. p-MAPK1/3 and DUSP6 regulate epididymal cell proliferation and survival in a region-specific manner in mice. Biol Reprod. 2010;83:807-17 pubmed 出版商

Wang P, Jin T. Hydrogen peroxide stimulates nuclear import of the POU homeodomain protein Oct-1 and its repressive effect on the expression of Cdx-2. BMC Cell Biol. 2010;11:56 pubmed 出版商

Böhm F, Speicher T, Hellerbrand C, Dickson C, Partanen J, Ornitz D, et al. FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice. Gastroenterology. 2010;139:1385-96 pubmed 出版商

Palozza P, Simone R, Catalano A, Monego G, Barini A, Mele M, et al. Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-?B nuclear binding and increase in PPAR? expression. J Nutr Biochem. 2011;22:259-68 pubmed 出版商

Lage K, Møllgård K, Greenway S, Wakimoto H, Gorham J, Workman C, et al. Dissecting spatio-temporal protein networks driving human heart development and related disorders. Mol Syst Biol. 2010;6:381 pubmed 出版商

Levy C, Slomiansky V, Gattelli A, Nahmod K, Pelisch F, Blaustein M, et al. Tumor necrosis factor alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells. J Cell Biochem. 2010;110:857-65 pubmed 出版商

Di X, Yan J, Zhao Y, Zhang J, Shi Z, Chang Y, et al. L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway. Neuroscience. 2010;168:778-86 pubmed 出版商

Gesslein B, Håkansson G, Carpio R, Gustafsson L, Perez M, Malmsjo M. Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion. Mol Vis. 2010;16:392-407 pubmed

Qi S, Liu Y, Hao L, Guan Q, Gu Y, Zhang J, et al. Neuroprotection of ethanol against ischemia/reperfusion-induced brain injury through decreasing c-Jun N-terminal kinase 3 (JNK3) activation by enhancing GABA release. Neuroscience. 2010;167:1125-37 pubmed 出版商

Witte F, Bernatik O, Kirchner K, Masek J, Mahl A, Krejci P, et al. Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2. FASEB J. 2010;24:2417-26 pubmed 出版商

Svensson C, Fernaeus S, Part K, Reis K, Land T. LPS-induced iNOS expression in Bv-2 cells is suppressed by an oxidative mechanism acting on the JNK pathway--a potential role for neuroprotection. Brain Res. 2010;1322:1-7 pubmed 出版商

Ikezoe T, Takeuchi T, Yang J, Adachi Y, Nishioka C, Furihata M, et al. Analysis of Aurora B kinase in non-Hodgkin lymphoma. Lab Invest. 2009;89:1364-73 pubmed 出版商

Cha J, Moon S, Kim H, Lee J, Lee K. The essential oil isolated from Artemisia capillaris prevents LPS-induced production of NO and PGE(2) by inhibiting MAPK-mediated pathways in RAW 264.7 macrophages. Immunol Invest. 2009;38:483-97 pubmed

Li C, Xu B, Wang W, Yu X, Zhu J, Yu H, et al. Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure. Epilepsia. 2010;51:391-403 pubmed 出版商

Zuo H, Liu Z, Liu X, Yang J, Liu T, Wen S, et al. CD151 gene delivery after myocardial infarction promotes functional neovascularization and activates FAK signaling. Mol Med. 2009;15:307-15 pubmed 出版商

Cha J, Jeong M, Kim H, Lee J, Lee K. MAPK activation is necessary to the apoptotic death of KB cells induced by the essential oil isolated from Artemisia iwayomogi. J Ethnopharmacol. 2009;123:308-14 pubmed 出版商

Pan J, Xiao Q, Sheng C, Hong Z, Yang H, Wang G, et al. Blockade of the translocation and activation of c-Jun N-terminal kinase 3 (JNK3) attenuates dopaminergic neuronal damage in mouse model of Parkinson's disease. Neurochem Int. 2009;54:418-25 pubmed 出版商

Palozza P, Torelli C, Boninsegna A, Simone R, Catalano A, Mele M, et al. Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Lett. 2009;283:108-17 pubmed 出版商

Meltser I, Tahera Y, Canlon B. Glucocorticoid receptor and mitogen-activated protein kinase activity after restraint stress and acoustic trauma. J Neurotrauma. 2009;26:1835-45 pubmed 出版商

Ottonello L, Bertolotto M, Montecucco F, Bianchi G, Dallegri F. Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. Br J Pharmacol. 2009;157:294-306 pubmed 出版商

Du Y, Li C, Hu W, Song Y, Zhang G. Neuroprotection of preconditioning against ischemic brain injury in rat hippocampus through inhibition of the assembly of GluR6-PSD95-mixed lineage kinase 3 signaling module via nuclear and non-nuclear pathways. Neuroscience. 2009;161:370-80 pubmed 出版商

Yang J, Zaja Milatovic S, Thu Y, Lee F, Smykla R, Richmond A. Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapy. Mol Cancer Ther. 2009;8:636-47 pubmed 出版商

Chiacchiera F, Simone C. Signal-dependent control of autophagy-related gene expression. Methods Enzymol. 2009;453:305-24 pubmed 出版商

Kanbe K, Inoue K, Inoue Y, Chen Q. Inducement of mitogen-activated protein kinases in frozen shoulders. J Orthop Sci. 2009;14:56-61 pubmed 出版商

Kook S, Hwang J, Park J, Kim E, Heo J, Jeon Y, et al. Mechanical force induces type I collagen expression in human periodontal ligament fibroblasts through activation of ERK/JNK and AP-1. J Cell Biochem. 2009;106:1060-7 pubmed 出版商

Palozza P, Simone R, Catalano A, Boninsegna A, Böhm V, Fröhlich K, et al. Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. J Nutr Biochem. 2010;21:34-46 pubmed 出版商

Romorini L, Coso O, Pecci A. Bcl-XL mediates epidermal growth factor dependent cell survival in HC11 mammary epithelial cells. Biochim Biophys Acta. 2009;1793:496-505 pubmed 出版商

Serrati S, Margheri F, Pucci M, Cantelmo A, Cammarota R, Dotor J, et al. TGFbeta1 antagonistic peptides inhibit TGFbeta1-dependent angiogenesis. Biochem Pharmacol. 2009;77:813-25 pubmed 出版商

Ooe N, Motonaga K, Kobayashi K, Saito K, Kaneko H. Functional characterization of basic helix-loop-helix-PAS type transcription factor NXF in vivo: putative involvement in an "on demand" neuroprotection system. J Biol Chem. 2009;284:1057-63 pubmed 出版商

Xu Y, Hou X, Liu Y, Zong Y. Different protection of K252a and N-acetyl-L-cysteine against amyloid-beta peptide-induced cortical neuron apoptosis involving inhibition of MLK3-MKK7-JNK3 signal cascades. J Neurosci Res. 2009;87:918-27 pubmed 出版商

Broide E, Scapa E, Bloch O, Shapiro M, Kimchi N, Ben Yehudah G, et al. Evidence for aberrant regulation of MAP kinase signal transduction pathway in peripheral blood mononuclear cells in patients with active celiac disease. Dig Dis Sci. 2009;54:1270-5 pubmed 出版商

Fuxman Bass J, Alvarez M, Gabelloni M, Vermeulen M, Amaral M, Geffner J, et al. GM-CSF enhances a CpG-independent pathway of neutrophil activation triggered by bacterial DNA. Mol Immunol. 2008;46:37-44 pubmed 出版商

Serini S, Trombino S, Oliva F, Piccioni E, Monego G, Resci F, et al. Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression. Apoptosis. 2008;13:1172-83 pubmed 出版商

Lagadinou E, Ziros P, Tsopra O, Dimas K, Kokkinou D, Thanopoulou E, et al. c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia. Leukemia. 2008;22:1899-908 pubmed 出版商

Nigro P, Dal Piaz F, Gallotta D, De Tommasi N, Belisario M. Inhibition of the thioredoxin system is a basis for the antileukemic potential of 13-hydroxy-15-oxo-zoapatlin. Free Radic Biol Med. 2008;45:875-84 pubmed 出版商

Li T, Yu X, Zhang G. Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region. FEBS Lett. 2008;582:1894-900 pubmed 出版商

Rieber M, Rieber M. Mcl-1 cleavage and sustained phosphorylation of c-Jun-N-terminal kinase mediate melanoma apoptosis induced by 2-acetyl furanonaphthoquinone: roles of Bcl-2 and p53. Cancer Biol Ther. 2008;7:1206-11 pubmed

Li T, Han D, Chen J, Yu X, Zhang G. Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression. Neuroreport. 2008;19:647-51 pubmed 出版商

Lee D, Yeh C, Chang S, Lee P, Chien S, Cheng C, et al. Integrin-mediated expression of bone formation-related genes in osteoblast-like cells in response to fluid shear stress: roles of extracellular matrix, Shc, and mitogen-activated protein kinase. J Bone Miner Res. 2008;23:1140-9 pubmed 出版商

Li J, Wang H, May S, Song X, Fueyo J, Fuller G, et al. Constitutive activation of c-Jun N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas. J Neurooncol. 2008;88:11-7 pubmed 出版商

Serrati S, Margheri F, Fibbi G, Di Cara G, Minafra L, Pucci Minafra I, et al. Endothelial cells and normal breast epithelial cells enhance invasion of breast carcinoma cells by CXCR-4-dependent up-regulation of urokinase-type plasminogen activator receptor (uPAR, CD87) expression. J Pathol. 2008;214:545-54 pubmed 出版商

Hu W, Du Y, Li C, Song Y, Zhang G. Neuroprotection of hypothermia against neuronal death in rat hippocampus through inhibiting the increased assembly of GluR6-PSD95-MLK3 signaling module induced by cerebral ischemia/reperfusion. Hippocampus. 2008;18:386-97 pubmed 出版商

Montecucco F, Steffens S, Burger F, Da Costa A, Bianchi G, Bertolotto M, et al. Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways. Cell Signal. 2008;20:557-68 pubmed 出版商

Sun W, Wang Q, Chen B, Liu J, Liu H, Xu W. Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling. Br J Nutr. 2008;99:1247-54 pubmed

Fan Y, Shimizu T, Yamada T, Nanashima N, Akita M, Asano J, et al. Development of glutathione S-transferase-P-negative foci accompanying nuclear factor-erythroid 2-related factor 2 expression during early stage of rat hepatocarcinogenesis. Cancer Sci. 2008;99:497-501 pubmed

Kook S, Son Y, Jang Y, Lee K, Lee S, Kim B, et al. Inhibition of c-Jun N-terminal kinase sensitizes tumor cells to flavonoid-induced apoptosis through down-regulation of JunD. Toxicol Appl Pharmacol. 2008;227:468-76 pubmed

Lai Y, Xin D, Bai J, Mao Z, Na Y. The important anti-apoptotic role and its regulation mechanism of PTTG1 in UV-induced apoptosis. J Biochem Mol Biol. 2007;40:966-72 pubmed

Loesberg W, Walboomers X, van Loon J, Jansen J. Simulated microgravity activates MAPK pathways in fibroblasts cultured on microgrooved surface topography. Cell Motil Cytoskeleton. 2008;65:116-29 pubmed

Pauli J, Ropelle E, Cintra D, Carvalho Filho M, Moraes J, De Souza C, et al. Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats. J Physiol. 2008;586:659-71 pubmed

Martin B, Kleiber K, Wixler V, Raab M, Zimmer B, Kaufmann M, et al. FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells. Cell Cycle. 2007;6:1779-88 pubmed

Fernandez V, Reyes S, Bravo S, Sepúlveda R, Romanque P, Santander G, et al. Involvement of Kupffer cell-dependent signaling in T3-induced hepatocyte proliferation in vivo. Biol Chem. 2007;388:831-7 pubmed

Jiang H, Guan Q, Pei D, Zhang G. Functional cooperation between KA2 and GluR6 subunits is involved in the ischemic brain injury. J Neurosci Res. 2007;85:2960-70 pubmed

Kato Y, Ozawa S, Tsukuda M, Kubota E, Miyazaki K, St Pierre Y, et al. Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma. FEBS J. 2007;274:3171-83 pubmed

Medeiros R, Prediger R, Passos G, Pandolfo P, Duarte F, Franco J, et al. Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein. J Neurosci. 2007;27:5394-404 pubmed

Tesz G, Guilherme A, Guntur K, Hubbard A, Tang X, Chawla A, et al. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem. 2007;282:19302-12 pubmed

Medeiros R, Passos G, Vitor C, Koepp J, Mazzuco T, Pianowski L, et al. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br J Pharmacol. 2007;151:618-27 pubmed

Montecucco F, Bianchi G, Bertolotto M, Viviani G, Dallegri F, Ottonello L. Insulin primes human neutrophils for CCL3-induced migration: crucial role for JNK 1/2. Ann N Y Acad Sci. 2006;1090:399-407 pubmed

Chiu J, Chen L, Lee C, Lee P, Lee D, Tsai M, et al. Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress. Blood. 2007;110:519-28 pubmed

Zhang Q, Pei D, Guan Q, Sun Y, Liu X, Zhang G. Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia. Biochemistry. 2007;46:4006-16 pubmed

Cho H, Morgan D, Bauer A, Kleeberger S. Signal transduction pathways of tumor necrosis factor--mediated lung injury induced by ozone in mice. Am J Respir Crit Care Med. 2007;175:829-39 pubmed

Zapata H, Nakatsugawa M, Moffat J. Varicella-zoster virus infection of human fibroblast cells activates the c-Jun N-terminal kinase pathway. J Virol. 2007;81:977-90 pubmed

Rovida E, Gozzini A, Barbetti V, Giuntoli S, Santini V, Dello Sbarba P. The c-Jun-N-terminal-Kinase inhibitor SP600125 enhances the butyrate derivative D1-induced apoptosis via caspase 8 activation in Kasumi 1 t(8;21) acute myeloid leukaemia cells. Br J Haematol. 2006;135:653-9 pubmed

Zhang Q, Tian H, Li H, Zhang G. Antioxidant N-acetylcysteine inhibits the activation of JNK3 mediated by the GluR6-PSD95-MLK3 signaling module during cerebral ischemia in rat hippocampus. Neurosci Lett. 2006;408:159-64 pubmed

Fu J, Ding Y, Huang D, Li H, Chen X. The retinoid X receptor-selective ligand, LGD1069, inhibits tumor-induced angiogenesis via suppression of VEGF in human non-small cell lung cancer. Cancer Lett. 2007;248:153-63 pubmed

Zhang Q, Han D, Xu J, Lv Q, Wang R, Yin X, et al. Ischemic preconditioning negatively regulates plenty of SH3s-mixed lineage kinase 3-Rac1 complex and c-Jun N-terminal kinase 3 signaling via activation of Akt. Neuroscience. 2006;143:431-44 pubmed

Nakuci E, Mahner S, DiRenzo J, ElShamy W. BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells. Exp Cell Res. 2006;312:3120-31 pubmed

Russ D, Lovering R. Influence of activation frequency on cellular signalling pathways during fatiguing contractions in rat skeletal muscle. Exp Physiol. 2006;91:957-66 pubmed

Santos C, Blanco S, Sevilla A, Lazo P. Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling. J Virol. 2006;80:7667-75 pubmed

Zhang Q, Wang X, Han D, Yin X, Zhang G, Xu T. Akt inhibits MLK3/JNK3 signaling by inactivating Rac1: a protective mechanism against ischemic brain injury. J Neurochem. 2006;98:1886-98 pubmed

Nielsen E, Eskildsen Helmond Y, Rattan S. MAP kinases and heat shock-induced hormesis in human fibroblasts during serial passaging in vitro. Ann N Y Acad Sci. 2006;1067:343-8 pubmed

Liu X, Pei D, Guan Q, Sun Y, Wang X, Zhang Q, et al. Neuroprotection of Tat-GluR6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways. J Biol Chem. 2006;281:17432-45 pubmed

Yu X, Luo A, Zhou C, Ding F, Wu M, Zhan Q, et al. Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells. Biochem Biophys Res Commun. 2006;342:286-92 pubmed

Meloni B, Tilbrook P, Boulos S, Arthur P, Knuckey N. Erythropoietin preconditioning in neuronal cultures: signaling, protection from in vitro ischemia, and proteomic analysis. J Neurosci Res. 2006;83:584-93 pubmed

Papachristou D, Papachristou G, Papachristou G, Papaefthimiou O, Agnantis N, Basdra E, et al. The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF. Histopathology. 2005;47:565-74 pubmed

Olson A, Protheroe K, Segar J, Scholz T. Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart. Am J Physiol Heart Circ Physiol. 2006;290:H1587-95 pubmed

Ammoun S, Lindholm D, Wootz H, Akerman K, Kukkonen J. G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase. J Biol Chem. 2006;281:834-42 pubmed

Tian H, Zhang Q, Zhu G, Pei D, Guan Q, Zhang G. Activation of c-Jun NH2-terminal kinase 3 is mediated by the GluR6.PSD-95.MLK3 signaling module following cerebral ischemia in rat hippocampus. Brain Res. 2005;1061:57-66 pubmed

Zhang Q, Wang R, Yin X, Pan J, Xu T, Zhang G. Knock-down of POSH expression is neuroprotective through down-regulating activation of the MLK3-MKK4-JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield. J Neurochem. 2005;95:784-95 pubmed

Polak P, Oren A, Ben Dror I, Steinberg D, Sapoznik S, Arditi Duvdevany A, et al. The cytoskeletal network controls c-Jun translation in a UTR-dependent manner. Oncogene. 2006;25:665-76 pubmed

Liang S, Zhang W, McGrath B, Zhang P, Cavener D. PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis. Biochem J. 2006;393:201-9 pubmed

Schmidt M, Budirahardja Y, Klompmaker R, Medema R. Ablation of the spindle assembly checkpoint by a compound targeting Mps1. EMBO Rep. 2005;6:866-72 pubmed

Papachristou D, Pirttiniemi P, Kantomaa T, Papavassiliou A, Basdra E. JNK/ERK-AP-1/Runx2 induction "paves the way" to cartilage load-ignited chondroblastic differentiation. Histochem Cell Biol. 2005;124:215-23 pubmed

Mun H, Aosai F, Norose K, Piao L, Fang H, Akira S, et al. Toll-like receptor 4 mediates tolerance in macrophages stimulated with Toxoplasma gondii-derived heat shock protein 70. Infect Immun. 2005;73:4634-42 pubmed

Ahmed Choudhury J, Williams K, Young L, Adams D, Afford S. CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cell Signal. 2006;18:456-68 pubmed

Hwang S, Yu S, Poo H, Chun J. c-Jun/activator protein-1 mediates interleukin-1beta-induced dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. J Biol Chem. 2005;280:29780-7 pubmed

Nadruz W, Corat M, Marin T, Guimarães Pereira G, Franchini K. Focal adhesion kinase mediates MEF2 and c-Jun activation by stretch: role in the activation of the cardiac hypertrophic genetic program. Cardiovasc Res. 2005;68:87-97 pubmed

Xiao D, Choi S, Lee Y, Singh S. Role of mitogen-activated protein kinases in phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells. Mol Carcinog. 2005;43:130-40 pubmed

Solorzano L, Rieber M, Medina J, Rieber M. Decreased glycolytic metabolism accelerates apoptosis in response to 2-acetyl furanonaphthoquinone in K1735 melanoma irrespective of bcl-2 overexpression. Cancer Biol Ther. 2005;4:329-35 pubmed

Butt A, Dickson K, Jambazov S, Baxter R. Enhancement of tumor necrosis factor-alpha-induced growth inhibition by insulin-like growth factor-binding protein-5 (IGFBP-5), but not IGFBP-3 in human breast cancer cells. Endocrinology. 2005;146:3113-22 pubmed

Cho H, Jedlicka A, Clarke R, Kleeberger S. Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ash. Physiol Genomics. 2005;22:108-17 pubmed

Garriock R, D Agostino S, Pilcher K, Krieg P. Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus. Dev Biol. 2005;279:179-92 pubmed

Ikezoe T, Yang Y, Taguchi H, Koeffler H. JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). Br J Cancer. 2004;90:2017-24 pubmed

Gonzalez M, Jimenez B, Berciano M, González Sancho J, Caelles C, Lafarga M, et al. Glucocorticoids antagonize AP-1 by inhibiting the Activation/phosphorylation of JNK without affecting its subcellular distribution. J Cell Biol. 2000;150:1199-208 pubmed