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Guo W, Liu W, Chen Z, Gu Y, Peng S, Shen L, et al. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun. 2017;8:2168 pubmed 出版商

Sauer M, Herbst J, Diekmann U, Rudd C, Kardinal C. SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells. Mol Cell Biol. 2016;36:3113-3127 pubmed

Kikuchi I, Takahashi Kanemitsu A, Sakiyama N, Tang C, Tang P, Noda S, et al. Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways. Nat Commun. 2016;7:12887 pubmed 出版商

Wang S, Zheng G, Zhao L, Xu F, Qian J. Shp-2 contributes to anti-RSV activity in human pulmonary alveolar epithelial cells by interfering with the IFN-α-induced Jak/Stat1 pathway. J Cell Mol Med. 2015;19:2432-40 pubmed 出版商

Zhao H, Agazie Y. Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment. BMC Cancer. 2015;15:109 pubmed 出版商

Osinalde N, Sánchez Quiles V, Akimov V, Guerra B, Blagoev B, Kratchmarova I. Simultaneous dissection and comparison of IL-2 and IL-15 signaling pathways by global quantitative phosphoproteomics. Proteomics. 2015;15:520-31 pubmed 出版商

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Ahmed T, Adamopoulos C, Karoulia Z, Wu X, Sachidanandam R, Aaronson S, et al. SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors. Cell Rep. 2019;26:65-78.e5 pubmed 出版商

Dorenkamp M, Müller J, Shanmuganathan K, Schulten H, Müller N, Löffler I, et al. Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis. Sci Rep. 2018;8:14684 pubmed 出版商

Zehender A, Huang J, Györfi A, Matei A, Trinh Minh T, Xu X, et al. The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat Commun. 2018;9:3259 pubmed 出版商

Li Q, Alsaidan O, Ma Y, Kim S, Liu J, Albers T, et al. Pharmacologically targeting the myristoylation of the scaffold protein FRS2α inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression. J Biol Chem. 2018;293:6434-6448 pubmed 出版商

Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens P, Neel B. Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2. Nat Commun. 2017;8:466 pubmed 出版商

Roccograndi L, Binder Z, Zhang L, Aceto N, Zhang Z, Bentires Alj M, et al. SHP2 regulates proliferation and tumorigenicity of glioma stem cells. J Neurooncol. 2017;135:487-496 pubmed 出版商

Nakano M, Yahiro K, Yamasaki E, Kurazono H, Akada J, Yamaoka Y, et al. Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase ?, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521. Dis Model Mech. 2016;9:1473-1481 pubmed

Tien S, Lee H, Yang Y, Lin M, Chen Y, Chang Z. The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42. Nat Commun. 2016;7:10420 pubmed 出版商

Matalkah F, Martin E, Zhao H, Agazie Y. SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer. Breast Cancer Res. 2016;18:2 pubmed 出版商

Craig J, Mikhailenko I, Noyes N, Migliorini M, Strickland D. The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events. PLoS ONE. 2013;8:e70432 pubmed 出版商

Hartman Z, Schaller M, Agazie Y. The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration. Mol Cancer Res. 2013;11:651-64 pubmed 出版商

He Z, Zhang S, Meng Q, Li S, Zhu H, Raquil M, et al. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Mol Cell Biol. 2012;32:1867-78 pubmed 出版商

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Pereira A, Clemente C, Cardoso A, Theizen T, Rocco S, Judice C, et al. MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice. PLoS ONE. 2009;4:e8472 pubmed 出版商

Yashiro M, Shinto O, Nakamura K, Tendo M, Matsuoka T, Matsuzaki T, et al. Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma. Int J Cancer. 2010;126:1004-16 pubmed 出版商

Schuman J, Chen Y, Podd A, Yu M, Liu H, Wen R, et al. A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. Blood. 2009;113:4566-74 pubmed 出版商

Camilleri A, Willmann R, Sadasivam G, Lin S, Ruegg M, Gesemann M, et al. Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors. BMC Neurosci. 2007;8:46 pubmed

Kuchay S, Kim N, Grunz E, Fay W, Chishti A. Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets. Mol Cell Biol. 2007;27:6038-52 pubmed

Park T, Boyd K, Curran T. Cardiovascular and craniofacial defects in Crk-null mice. Mol Cell Biol. 2006;26:6272-82 pubmed

Monteleone G, Franchi L, Fina D, Caruso R, Vavassori P, Monteleone I, et al. Silencing of SH-PTP2 defines a crucial role in the inactivation of epidermal growth factor receptor by 5-aminosalicylic acid in colon cancer cells. Cell Death Differ. 2006;13:202-11 pubmed

Mortaz E, Redegeld F, van der Heijden M, Wong H, Nijkamp F, Engels F. Mast cell activation is differentially affected by heat shock. Exp Hematol. 2005;33:944-52 pubmed

Sun H, Shen Y, Dokainish H, Holgado Madruga M, Wong A, Ireton K. Host adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes. Cell Microbiol. 2005;7:443-57 pubmed