产品简要
公司名称 :
圣克鲁斯生物技术
产品类型 :
抗体
产品名称 :
p21(187)抗体
目录 :
sc-817
规格 :
200微克/毫升
价格 :
279美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
187
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 75
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 图 3f
Yu G, Zhang T, Jing Y, Bao Q, Tang Q, Zhang Y. miR-519 suppresses nasopharyngeal carcinoma cell proliferation by targeting oncogene URG4/URGCP. Life Sci. 2017;175:47-51 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2g
Coni S, Mancuso A, Di Magno L, Sdruscia G, Manni S, Serrao S, et al. Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. Sci Rep. 2017;7:44079 pubmed 出版商
  • 免疫印迹; 人类; 图 5d
Jin X, Wu N, Dai J, Li Q, Xiao X. TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4-phenylbutyrate treatment. Cancer Med. 2017;6:424-438 pubmed 出版商
  • 免疫印迹; 人类; 图 7d
Bauer M, Joerger A, Fersht A. 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. Proc Natl Acad Sci U S A. 2016;113:E5271-80 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, et al. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 2016;17:349-66 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Felli N, Errico M, Pedini F, Petrini M, Puglisi R, Bellenghi M, et al. AP2α controls the dynamic balance between miR-126&126* and miR-221&222 during melanoma progression. Oncogene. 2016;35:3016-26 pubmed 出版商
  • 免疫印迹; 人类; 图 9
Mehraein Ghomi F, Church D, Schreiber C, Weichmann A, Basu H, Wilding G. Inhibitor of p52 NF-κB subunit and androgen receptor (AR) interaction reduces growth of human prostate cancer cells by abrogating nuclear translocation of p52 and phosphorylated AR(ser81). Genes Cancer. 2015;6:428-44 pubmed
  • 免疫组化; 人类; 图 1
Bauer J, Ozden O, Akagi N, Carroll T, Principe D, Staudacher J, et al. Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. Mol Cancer. 2015;14:182 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 7
Mansara P, Deshpande R, Vaidya M, Kaul Ghanekar R. Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231. PLoS ONE. 2015;10:e0136542 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Patel A, Burton D, Halvorsen K, Balkan W, Reiner T, Perez Stable C, et al. MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways. Oncogene. 2015;34:2586-96 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Yang G, Chang B, Yang F, Guo X, Cai K, Xiao X, et al. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010;16:3171-81 pubmed 出版商
  • 免疫沉淀; 人类; 1 ug/time
  • 免疫印迹; 人类
Meng L, Kohn K, Pommier Y. Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288). Oncogene. 2007;26:4806-16 pubmed
Zhao X, Huang L, Xu W, Chen X, Shen Y, Zeng W, et al. Physapubescin B inhibits tumorgenesis and circumvents taxol resistance of ovarian cancer cells through STAT3 signaling. Oncotarget. 2017;8:70130-70141 pubmed 出版商
Florean C, Schnekenburger M, Lee J, Kim K, Mazumder A, Song S, et al. Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells. Oncotarget. 2016;7:24027-49 pubmed 出版商
Tatsumi Y, Takano R, Islam M, Yokochi T, Itami M, Nakamura Y, et al. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell Death Dis. 2015;6:e1607 pubmed 出版商
Yeh C, Yen C, Chen Y, Cheng C, Huang S, Chang T, et al. Identification of aurora kinase A as an unfavorable prognostic factor and potential treatment target for metastatic gastrointestinal stromal tumors. Oncotarget. 2014;5:4071-86 pubmed
Allen M, Andrysik Z, Dengler V, Mellert H, Guarnieri A, Freeman J, et al. Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms. elife. 2014;3:e02200 pubmed 出版商
Burton D, Giribaldi M, Muñoz A, Halvorsen K, Patel A, Jorda M, et al. Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cells. PLoS ONE. 2013;8:e68003 pubmed 出版商
Chang M, Kim D, Roh J, Middeldorp J, Kim Y, Kim S, et al. Epstein-Barr virus-encoded BARF1 promotes proliferation of gastric carcinoma cells through regulation of NF-?B. J Virol. 2013;87:10515-23 pubmed 出版商
Chiappara G, Gjomarkaj M, Virzì A, Sciarrino S, Ferraro M, Bruno A, et al. The role of p21 Waf1/Cip1 in large airway epithelium in smokers with and without COPD. Biochim Biophys Acta. 2013;1832:1473-81 pubmed 出版商
Cui C, Wang Y, Wang Y, Zhao M, Peng S. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. J Anal Methods Chem. 2013;2013:602091 pubmed 出版商
Litwiniec A, Gackowska L, Helmin Basa A, Zuryn A, Grzanka A. Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin. Cancer Cell Int. 2013;13:9 pubmed 出版商
Sun L, Chen L, Sun L, Pan J, Yu L, Han L, et al. Functional screen for secreted proteins by monoclonal antibody library and identification of Mac-2 Binding protein (Mac-2BP) as a potential therapeutic target and biomarker for lung cancer. Mol Cell Proteomics. 2013;12:395-406 pubmed 出版商
Salvatori B, Iosue I, Mangiavacchi A, Loddo G, Padula F, Chiaretti S, et al. The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells. Cell Death Dis. 2012;3:e413 pubmed 出版商
Dey P, Jonsson P, Hartman J, Williams C, Strom A, Gustafsson J. Estrogen receptors ?1 and ?2 have opposing roles in regulating proliferation and bone metastasis genes in the prostate cancer cell line PC3. Mol Endocrinol. 2012;26:1991-2003 pubmed 出版商
Chanda D, Bhushan S, Guru S, Shanker K, Wani Z, Rah B, et al. Anticancer activity, toxicity and pharmacokinetic profile of an indanone derivative. Eur J Pharm Sci. 2012;47:988-95 pubmed 出版商
Bauer J, Sporn J, Cabral J, Gomez J, Jung B. Effects of activin and TGF? on p21 in colon cancer. PLoS ONE. 2012;7:e39381 pubmed 出版商
Ranganathan P, Yu X, Na C, Santhanam R, Shacham S, Kauffman M, et al. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood. 2012;120:1765-73 pubmed 出版商
Watt H, Rachid Z, Jean Claude B. The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries. J Signal Transduct. 2012;2012:282050 pubmed 出版商
Wan X, Zhao Y, Fan X, Cai H, Zhang Y, Chen M, et al. Molecular prognostic prediction for locally advanced nasopharyngeal carcinoma by support vector machine integrated approach. PLoS ONE. 2012;7:e31989 pubmed 出版商
Tsapakidis K, Vlachostergios P, Voutsadakis I, Befani C, Patrikidou A, Hatzidaki E, et al. Bortezomib reverses the proliferative and antiapoptotic effect of neuropeptides on prostate cancer cells. Int J Urol. 2012;19:565-74 pubmed 出版商
Sivachandran N, Dawson C, Young L, Liu F, Middeldorp J, Frappier L. Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinoma. J Virol. 2012;86:60-8 pubmed 出版商
Lin Y, Chiang B. 4-acetylantroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels. J Agric Food Chem. 2011;59:8625-31 pubmed 出版商
Xing R, Li W, Cui J, Zhang J, Kang B, Wang Y, et al. Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells. Gut. 2012;61:43-52 pubmed 出版商
Kisova A, Zerzankova L, Habtemariam A, Sadler P, Brabec V, Kasparkova J. Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Mol Pharm. 2011;8:949-57 pubmed 出版商
Fan L, Chiang W, Liang C, Tsai Y, Wong T, Chen K, et al. ?-Catulin knockdown induces senescence in cancer cells. Oncogene. 2011;30:2610-21 pubmed 出版商
von Guggenberg E, Shahhosseini S, Koslowsky I, Lavasanifar A, Murray D, Mercer J. In vitro characterization of two novel biodegradable vectors for the delivery of radiolabeled antisense oligonucleotides. Cancer Biother Radiopharm. 2010;25:723-31 pubmed 出版商
Nadalutti C, Viiri K, Kaukinen K, Maki M, Lindfors K. Extracellular transglutaminase 2 has a role in cell adhesion, whereas intracellular transglutaminase 2 is involved in regulation of endothelial cell proliferation and apoptosis. Cell Prolif. 2011;44:49-58 pubmed 出版商
Rai P, Young J, Burton D, Giribaldi M, Onder T, Weinberg R. Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence. Oncogene. 2011;30:1489-96 pubmed 出版商
Sarkari F, Sheng Y, Frappier L. USP7/HAUSP promotes the sequence-specific DNA binding activity of p53. PLoS ONE. 2010;5:e13040 pubmed 出版商
Terazawa R, Garud D, Hamada N, Fujita Y, Itoh T, Nozawa Y, et al. Identification of organoselenium compounds that possess chemopreventive properties in human prostate cancer LNCaP cells. Bioorg Med Chem. 2010;18:7001-8 pubmed 出版商
Chen Y, Yu G, Yu D, Zhu M. PKCalpha-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-beta1. J Exp Clin Cancer Res. 2010;29:104 pubmed 出版商
Voutsadakis I, Patrikidou A, Tsapakidis K, Karagiannaki A, Hatzidaki E, Stathakis N, et al. Additive inhibition of colorectal cancer cell lines by aspirin and bortezomib. Int J Colorectal Dis. 2010;25:795-804 pubmed 出版商
Young J, Patel A, Rai P. Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts. Biochem Biophys Res Commun. 2010;392:363-8 pubmed 出版商
Komissarova E, Rossman T. Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure. Toxicol Appl Pharmacol. 2010;243:399-404 pubmed 出版商
Peirce S, Findley H. High level MycN expression in non-MYCN amplified neuroblastoma is induced by the combination treatment nutlin-3 and doxorubicin and enhances chemosensitivity. Oncol Rep. 2009;22:1443-9 pubmed
Sun J, Li Z, Hu Z, Zeng Z, Yang D, Jiang W. Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells. Oncol Rep. 2009;22:193-8 pubmed
Trougakos I, Lourda M, Antonelou M, Kletsas D, Gorgoulis V, Papassideri I, et al. Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res. 2009;15:48-59 pubmed 出版商
Zhuang Y, Miskimins W. Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1. J Mol Signal. 2008;3:18 pubmed 出版商
Zhuang Z, Fei F, Chen Y, Jin W. Suberoyl bis-hydroxamic acid induces p53-dependent apoptosis of MCF-7 breast cancer cells. Acta Pharmacol Sin. 2008;29:1459-66 pubmed 出版商
Soroka Y, Ma or Z, Leshem Y, Verochovsky L, Neuman R, Brégégère F, et al. Aged keratinocyte phenotyping: morphology, biochemical markers and effects of Dead Sea minerals. Exp Gerontol. 2008;43:947-57 pubmed 出版商
Burich R, Holland W, Vinall R, Tepper C, White R, Mack P. Genistein combined polysaccharide enhances activity of docetaxel, bicalutamide and Src kinase inhibition in androgen-dependent and independent prostate cancer cell lines. BJU Int. 2008;102:1458-66 pubmed 出版商
Shiota M, Izumi H, Onitsuka T, Miyamoto N, Kashiwagi E, Kidani A, et al. Twist and p53 reciprocally regulate target genes via direct interaction. Oncogene. 2008;27:5543-53 pubmed 出版商
Katsoulas A, Rachid Z, McNamee J, Williams C, Jean Claude B. Combi-targeting concept: an optimized single-molecule dual-targeting model for the treatment of chronic myelogenous leukemia. Mol Cancer Ther. 2008;7:1033-43 pubmed 出版商
Lei K, Townsend D, Tew K. Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response. Oncogene. 2008;27:4877-87 pubmed 出版商
Howell M, Fairchild H, Kim B, Bin L, Boguniewicz M, Redzic J, et al. Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation. J Invest Dermatol. 2008;128:2248-58 pubmed 出版商
Lukandu O, Costea D, Dimba E, Neppelberg E, Bredholt T, Gjertsen B, et al. Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts. Eur J Oral Sci. 2008;116:23-30 pubmed 出版商
Poulios E, Trougakos I, Chondrogianni N, Gonos E. Exposure of human diploid fibroblasts to hypoxia extends proliferative life span. Ann N Y Acad Sci. 2007;1119:9-19 pubmed
Warnock L, Adamson R, Lynch C, Milner J. Crosstalk between site-specific modifications on p53 and histone H3. Oncogene. 2008;27:1639-44 pubmed
Fujikawa M, Katagiri T, Tugores A, Nakamura Y, Ishikawa F. ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence. Cancer Sci. 2007;98:1468-75 pubmed
Akgul B, Ghali L, Davies D, Pfister H, Leigh I, Storey A. HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes. Exp Dermatol. 2007;16:590-9 pubmed
Lévêque C, Marsaud V, Renoir J, Sola B. Alternative cyclin D1 forms a and b have different biological functions in the cell cycle of B lymphocytes. Exp Cell Res. 2007;313:2719-29 pubmed
Sirach E, Bureau C, Peron J, Pradayrol L, Vinel J, Buscail L, et al. KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis. Cell Death Differ. 2007;14:1202-10 pubmed
Sadikovic B, Rodenhiser D. Benzopyrene exposure disrupts DNA methylation and growth dynamics in breast cancer cells. Toxicol Appl Pharmacol. 2006;216:458-68 pubmed
Ndoye A, Dolivet G, Høgset A, Leroux A, Fifre A, Erbacher P, et al. Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization. Mol Ther. 2006;13:1156-62 pubmed
Gomes N, Bjerke G, Llorente B, Szostek S, Emerson B, Espinosa J. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev. 2006;20:601-12 pubmed
Bermejo Rodríguez C, Perez Caro M, Pérez Mancera P, Sanchez Beato M, Piris M, Sanchez Garcia I. Mouse cDNA microarray analysis uncovers Slug targets in mouse embryonic fibroblasts. Genomics. 2006;87:113-8 pubmed
Dworakowska D, Jassem E, Jassem J, Karmolinski A, Dworakowski R, Wirth T, et al. Clinical significance of apoptotic index in non-small cell lung cancer: correlation with p53, mdm2, pRb and p21WAF1/CIP1 protein expression. J Cancer Res Clin Oncol. 2005;131:617-23 pubmed
Meng L, Kohlhagen G, Liao Z, Antony S, Sausville E, Pommier Y. DNA-protein cross-links and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against human breast cancer cells. Cancer Res. 2005;65:5337-43 pubmed
Papazisis K, Kalemi T, Zambouli D, Geromichalos G, Lambropoulos A, Kotsis A, et al. Synergistic effects of protein tyrosine kinase inhibitor genistein with camptothecins against three cell lines in vitro. Cancer Lett. 2006;233:255-64 pubmed
Funato N, Twigg S, Higashihori N, Ohyama K, Wall S, Wilkie A, et al. Functional analysis of natural mutations in two TWIST protein motifs. Hum Mutat. 2005;25:550-6 pubmed
Ohata M, Koyama Y, Suzuki T, Hayakawa S, Saeki K, Nakamura Y, et al. Effects of tea constituents on cell cycle progression of human leukemia U937 cells. Biomed Res. 2005;26:1-7 pubmed
Shen Z, Nishida K, Doi H, Oohashi T, Hirohata S, Ozaki T, et al. Suppression of chondrosarcoma cells by 15-deoxy-Delta 12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21. Biochem Biophys Res Commun. 2005;328:375-82 pubmed
Okumura H, Natsugoe S, Matsumoto M, Mataki Y, Takatori H, Ishigami S, et al. The predictive value of p53, p53R2, and p21 for the effect of chemoradiation therapy on oesophageal squamous cell carcinoma. Br J Cancer. 2005;92:284-9 pubmed
Lee E, Gerhold M, Palmer M, Christen R. p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection. Br J Cancer. 2003;88:754-9 pubmed
产品信息
产品名称 :
p21(187)抗体
基因名称 :
CDKN1A
规格 :
200微克/毫升
价格 :
279美元
目录号 :
sc-817
类型 :
单克隆
宿主 :
小鼠单克隆
抗原 :
p21
反应物种 :
m, r, h
应用 :
免疫印迹, 免疫沉淀, IF, 免疫组化(P), 酶联免疫吸附测定
表位 :
FL(人类)
交货时间 :
在下午三点前下订单在美国的次日送达;从我们美国的办公室通过国际航运两日后送达;在我们的欧洲办事处下订单次日运抵欧洲客户
更多信息或购买 :
公司信息
圣克鲁斯生物技术
上海浦东新区建业路315号2号楼1-6号
asia@scbio.cn
www.scbt.com/zh/
800-820-8626
公司总部: 美国
圣克鲁斯生物技术公司拥有最高的质量承诺和客户服务。