Paspalas C, Carlyle B, Leslie S, Preuss T, Crimins J, Huttner A, et al. The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology. Alzheimers Dement. 2018;14:680-691 pubmed 出版商

Benvegnù S, Wahle T, Dotti C. E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Oncotarget. 2017;8:89439-89450 pubmed 出版商

Takahashi H, Klein Z, Bhagat S, Kaufman A, Kostylev M, Ikezu T, et al. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017;133:785-807 pubmed 出版商

Park T, Ryu Y, Park H, Kim J, Go J, Noh J, et al. Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. Int J Mol Med. 2017;39:21-30 pubmed 出版商

Chapuis J, Flaig A, Grenier Boley B, Eysert F, Pottiez V, Deloison G, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathol. 2017;133:955-966 pubmed 出版商

CARTAGENA C, Mountney A, Hwang H, Swiercz A, Rammelkamp Z, Boutte A, et al. Subacute Changes in Cleavage Processing of Amyloid Precursor Protein and Tau following Penetrating Traumatic Brain Injury. PLoS ONE. 2016;11:e0158576 pubmed 出版商

Bergkvist L, Sandin L, Kågedal K, Brorsson A. A?PP processing results in greater toxicity per amount of A?1-42 than individually expressed and secreted A?1-42 in Drosophila melanogaster. Biol Open. 2016;5:1030-9 pubmed 出版商

Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed 出版商

Herring A, Münster Y, Metzdorf J, Bolczek B, Krüssel S, Krieter D, et al. Late running is not too late against Alzheimer's pathology. Neurobiol Dis. 2016;94:44-54 pubmed 出版商

Kurkinen K, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, et al. SEPT8 modulates ?-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. J Cell Sci. 2016;129:2224-38 pubmed 出版商

Triaca V, Sposato V, Bolasco G, Ciotti M, Pelicci P, Bruni A, et al. NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease. Aging Cell. 2016;15:661-72 pubmed 出版商

Sun M, Asghar S, Zhang H. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. Neurobiol Dis. 2016;93:1-11 pubmed 出版商

Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed 出版商

Dooves S, Bugiani M, Postma N, Polder E, Land N, Horan S, et al. Astrocytes are central in the pathomechanisms of vanishing white matter. J Clin Invest. 2016;126:1512-24 pubmed 出版商

Kuhn P, Colombo A, Schusser B, Dreymueller D, Wetzel S, Schepers U, et al. Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. elife. 2016;5: pubmed 出版商

Maurya S, Mishra J, Abbas S, Bandyopadhyay S. Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators. Mol Neurobiol. 2016;53:968-82 pubmed 出版商

Parsi S, Smith P, Goupil C, Dorval V, Hébert S. Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease. Mol Ther Nucleic Acids. 2015;4:e256 pubmed 出版商

Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed 出版商

Liu J, Liu S, Matsumoto Y, Murakami S, Sugakawa Y, Kami A, et al. Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology. Sci Rep. 2015;5:12059 pubmed 出版商

von Einem B, Wahler A, Schips T, Serrano Pozo A, Proepper C, Boeckers T, et al. The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1). PLoS ONE. 2015;10:e0129047 pubmed 出版商

Li H, Ruberu K, Muñoz S, Jenner A, Spiro A, Zhao H, et al. Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice. Neurobiol Aging. 2015;36:1820-33 pubmed 出版商

Sabogal Guáqueta A, Muñoz Manco J, Ramírez Pineda J, Lamprea Rodriguez M, Osorio E, Cardona Gómez G. The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice. Neuropharmacology. 2015;93:134-45 pubmed 出版商

Sobol A, Galluzzo P, Weber M, Alani S, Bocchetta M. Depletion of Amyloid Precursor Protein (APP) causes G0 arrest in non-small cell lung cancer (NSCLC) cells. J Cell Physiol. 2015;230:1332-41 pubmed 出版商

Shukla M, Htoo H, Wintachai P, Hernandez J, Dubois C, Postina R, et al. Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17. J Pineal Res. 2015;58:151-65 pubmed 出版商

Maloney J, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, et al. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein. J Biol Chem. 2014;289:30990-1000 pubmed 出版商

Tam J, Seah C, Pasternak S. The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid. Mol Brain. 2014;7:54 pubmed 出版商

Zhao Z, Wu L, Xiong R, Wang L, Zhang B, Wang C, et al. MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer's disease. Neuroscience. 2014;275:232-7 pubmed 出版商

Tan M, Yu J, Jiang T, Zhu X, Guan H, Tan L. IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice. J Alzheimers Dis. 2014;38:633-46 pubmed 出版商

Doshina A, Gourgue F, Onizuka M, Opsomer R, Wang P, Ando K, et al. Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission. Sci Rep. 2017;7:370 pubmed 出版商

Lu J, Li X, Wang Q, Pei G. Dopamine D2 receptor and β-arrestin 2 mediate Amyloid-β elevation induced by anti-parkinson's disease drugs, levodopa and piribedil, in neuronal cells. PLoS ONE. 2017;12:e0173240 pubmed 出版商

Guo Y, Zhang P, Zhang H, Zhang P, Xu R. RNAi for contactin 2 inhibits proliferation of U87-glioma stem cells by downregulating AICD, EGFR, and HES1. Onco Targets Ther. 2017;10:791-801 pubmed 出版商

Canu N, Pagano I, La Rosa L, Pellegrino M, Ciotti M, Mercanti D, et al. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Front Mol Neurosci. 2017;10:15 pubmed 出版商

Zoltowska K, Maesako M, Lushnikova I, Takeda S, Keller L, Skibo G, et al. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production. Mol Neurodegener. 2017;12:15 pubmed 出版商

Htoo H, Limsuvan S, Thamsermsang O, Hernandez J, Checler F, Govitrapong P, et al. The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing ?-Secretase Activities. PLoS ONE. 2017;12:e0170360 pubmed 出版商

Schaefer P, von Einem B, Walther P, Calzia E, von Arnim C. Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration. PLoS ONE. 2016;11:e0168157 pubmed 出版商

Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed 出版商

Zhao H, Wu H, He J, Zhuang J, Liu Z, Yang Y, et al. Frontal cortical mitochondrial dysfunction and mitochondria-related β-amyloid accumulation by chronic sleep restriction in mice. Neuroreport. 2016;27:916-22 pubmed 出版商

Belichenko P, Madani R, Rey Bellet L, Pihlgren M, Becker A, Plassard A, et al. An Anti-?-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. PLoS ONE. 2016;11:e0152471 pubmed 出版商

di Fede G, Catania M, Maderna E, Morbin M, Moda F, Colombo L, et al. Tackling amyloidogenesis in Alzheimer's disease with A2V variants of Amyloid-β. Sci Rep. 2016;6:20949 pubmed 出版商

Kerridge C, Kozlova D, Nalivaeva N, Turner A. Hypoxia Affects Neprilysin Expression Through Caspase Activation and an APP Intracellular Domain-dependent Mechanism. Front Neurosci. 2015;9:426 pubmed 出版商

Wang J, Lu R, Yang J, Li H, He Z, Jing N, et al. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production. Nat Commun. 2015;6:8876 pubmed 出版商

Wang X, Perumalsamy H, Kwon H, Na Y, Ahn Y. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease. Sci Rep. 2015;5:16127 pubmed 出版商

Prokop S, Miller K, Drost N, Handrick S, Mathur V, Luo J, et al. Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice. J Exp Med. 2015;212:1811-8 pubmed 出版商

Wang Q, Xiao B, Cui S, Song H, Qian Y, Dong L, et al. Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD. Dis Model Mech. 2014;7:1385-95 pubmed 出版商

Jung J, Premraj S, Cruz P, Ladd T, Kwak Y, Koo E, et al. Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity. PLoS ONE. 2014;9:e111553 pubmed 出版商

Merezhko M, Muggalla P, Nykänen N, Yan X, Sakha P, Huttunen H. Multiplex assay for live-cell monitoring of cellular fates of amyloid-? precursor protein (APP). PLoS ONE. 2014;9:e98619 pubmed 出版商

Branca C, Sarnico I, Ruotolo R, Lanzillotta A, Viscomi A, Benarese M, et al. Pharmacological targeting of the ?-amyloid precursor protein intracellular domain. Sci Rep. 2014;4:4618 pubmed 出版商

Wagner S, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson K, et al. Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ? peptide variant and augment the production of multiple carboxy-truncated amyloid ? species. Biochemistry. 2014;53:702-13 pubmed 出版商

Kim J, Yoon J, Kim Y. HIV-1 Tat interacts with and regulates the localization and processing of amyloid precursor protein. PLoS ONE. 2013;8:e77972 pubmed 出版商

Robinson A, Grösgen S, Mett J, Zimmer V, Haupenthal V, Hundsdörfer B, et al. Upregulation of PGC-1? expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP. Aging Cell. 2014;13:263-72 pubmed 出版商

Hendrickx A, Pierrot N, Tasiaux B, Schakman O, Brion J, Kienlen Campard P, et al. Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty. PLoS ONE. 2013;8:e74305 pubmed 出版商

Bandyopadhyay S, Cahill C, Balleidier A, Huang C, Lahiri D, Huang X, et al. Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease. PLoS ONE. 2013;8:e65978 pubmed 出版商

Hong X, Bu L, Wang Y, Xu J, Wu J, Huang Y, et al. Increases in the risk of cognitive impairment and alterations of cerebral ?-amyloid metabolism in mouse model of heart failure. PLoS ONE. 2013;8:e63829 pubmed 出版商

Karlsson P, Droce A, Moser J, Cuhlmann S, Padilla C, Heimann P, et al. Loss of vps54 function leads to vesicle traffic impairment, protein mis-sorting and embryonic lethality. Int J Mol Sci. 2013;14:10908-25 pubmed 出版商

Stemmer N, Strekalova E, Djogo N, Plöger F, Loers G, Lutz D, et al. Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin. PLoS ONE. 2013;8:e61299 pubmed 出版商

Hara S, Arawaka S, Sato H, Machiya Y, Cui C, Sasaki A, et al. Serine 129 phosphorylation of membrane-associated ?-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner. Mol Biol Cell. 2013;24:1649-60, S1-3 pubmed 出版商

Caceres N, Aerts M, Marquez B, Mingeot Leclercq M, Tulkens P, Devreese B, et al. Analysis of the membrane proteome of ciprofloxacin-resistant macrophages by stable isotope labeling with amino acids in cell culture (SILAC). PLoS ONE. 2013;8:e58285 pubmed 出版商

Steuble M, Diep T, Sch tzle P, Ludwig A, Tagaya M, Kunz B, et al. Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport. Biol Open. 2012;1:761-74 pubmed 出版商

Yang S, Wang S, Zhao M, Zhang R, Zhou W, Li Y, et al. A peptide binding to the ?-site of APP improves spatial memory and attenuates A? burden in Alzheimer's disease transgenic mice. PLoS ONE. 2012;7:e48540 pubmed 出版商

Pintchovski S, Schenk D, Basi G. Evidence that enzyme processivity mediates differential A? production by PS1 and PS2. Curr Alzheimer Res. 2013;10:4-10 pubmed

Sarajärvi T, Lipsanen A, Mäkinen P, Peräniemi S, Soininen H, Haapasalo A, et al. Bepridil decreases A? and calcium levels in the thalamus after middle cerebral artery occlusion in rats. J Cell Mol Med. 2012;16:2754-67 pubmed 出版商

Kakiya N, Saito T, Nilsson P, Matsuba Y, Tsubuki S, Takei N, et al. Cell surface expression of the major amyloid-? peptide (A?)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1. J Biol Chem. 2012;287:29362-72 pubmed 出版商

Krstic D, Madhusudan A, Doehner J, Vogel P, Notter T, Imhof C, et al. Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice. J Neuroinflammation. 2012;9:151 pubmed 出版商

Cacquevel M, Aeschbach L, Houacine J, Fraering P. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified ?-secretase complexes. PLoS ONE. 2012;7:e35133 pubmed 出版商

Lewis V, Whitehouse I, Baybutt H, Manson J, Collins S, Hooper N. Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain. PLoS ONE. 2012;7:e31754 pubmed 出版商

Sanchez Varo R, Trujillo Estrada L, Sanchez Mejias E, Torres M, Baglietto Vargas D, Moreno Gonzalez I, et al. Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus. Acta Neuropathol. 2012;123:53-70 pubmed 出版商

Amtul Z, Keet M, Wang L, Merrifield P, Westaway D, Rozmahel R. DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet?. PLoS ONE. 2011;6:e24094 pubmed 出版商

Demars M, Bartholomew A, Strakova Z, Lazarov O. Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin. Stem Cell Res Ther. 2011;2:36 pubmed 出版商

Saito Y, Akiyama M, Araki Y, Sumioka A, Shiono M, Taru H, et al. Intracellular trafficking of the amyloid ?-protein precursor (APP) regulated by novel function of X11-like. PLoS ONE. 2011;6:e22108 pubmed 出版商

Hiltunen M, Khandelwal V, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, et al. Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice. J Cell Mol Med. 2012;16:1206-22 pubmed 出版商

Chakraborty R, Vepuri V, Mhatre S, Paddock B, Miller S, Michelson S, et al. Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects. PLoS ONE. 2011;6:e20799 pubmed 出版商

Cheng S, Ferland P, Webster P, Bearer E. Herpes simplex virus dances with amyloid precursor protein while exiting the cell. PLoS ONE. 2011;6:e17966 pubmed 出版商

Basi G, Hemphill S, Brigham E, Liao A, Aubele D, Baker J, et al. Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease. Alzheimers Res Ther. 2010;2:36 pubmed 出版商

Wang C, Wang T, Zheng W, Zhao B, Danscher G, Chen Y, et al. Zinc overload enhances APP cleavage and A? deposition in the Alzheimer mouse brain. PLoS ONE. 2010;5:e15349 pubmed 出版商

Fustiñana M, Ariel P, Federman N, Freudenthal R, Romano A. Characterization of the beta amyloid precursor protein-like gene in the central nervous system of the crab Chasmagnathus. Expression during memory consolidation. BMC Neurosci. 2010;11:109 pubmed 出版商

Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R, et al. Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat Cell Biol. 2010;12:41-6; sup pp 1-8 pubmed 出版商

Futai E, Yagishita S, Ishiura S. Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations. J Biol Chem. 2009;284:13013-22 pubmed 出版商