产品简要
公司名称 :
西格玛奥德里奇
其他品牌 :
FLUKA
产品类型 :
抗体
产品名称 :
抗LC3在兔生产的抗体
目录 :
L8918
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, proximity ligation assay, 其他
更多信息或购买 :
文章摘录数: 59
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 图 2g
Liu D, Wu H, Wang C, Li Y, Tian H, Siraj S, et al. STING directly activates autophagy to tune the innate immune response. Cell Death Differ. 2018;: pubmed 出版商
  • 免疫细胞化学; 人类; 1:50; 图 7a
  • 免疫印迹; 人类; 图 5a
Guo J, Fang W, Chen X, Lin Y, Hu G, Wei J, et al. Upstream stimulating factor 1 suppresses autophagy and hepatic lipid droplet catabolism by activating mTOR. FEBS Lett. 2018;592:2725-2738 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5b
Bustos V, Pulina M, Kelahmetoglu Y, Sinha S, Gorelick F, Flajolet M, et al. Bidirectional regulation of Aβ levels by Presenilin 1. Proc Natl Acad Sci U S A. 2017;114:7142-7147 pubmed 出版商
  • 免疫印迹; 人类; 图 3a,4a,4i,4j
Li Y, Chang Y, Ye N, Dai D, Chen Y, Zhang N, et al. Advanced Glycation End Products Inhibit the Proliferation of Human Umbilical Vein Endothelial Cells by Inhibiting Cathepsin D. Int J Mol Sci. 2017;18: pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 2E
  • 免疫印迹; 小鼠; 1:2000; 图 2A
Redmann M, Wani W, Volpicelli Daley L, Darley Usmar V, Zhang J. Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils. Redox Biol. 2017;11:429-437 pubmed 出版商
  • 免疫印迹; 人类; 1:2500; 图 s1
Piccolella M, Crippa V, Cristofani R, Rusmini P, Galbiati M, Cicardi M, et al. The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells. Oncotarget. 2017;8:10400-10415 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 3d
Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, et al. MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun. 2016;7:12109 pubmed 出版商
  • 免疫印迹; 大鼠; 1:600; 图 2
Gui L, Liu B, Lv G. Hypoxia induces autophagy in cardiomyocytes via a hypoxia-inducible factor 1-dependent mechanism. Exp Ther Med. 2016;11:2233-2239 pubmed
  • 免疫印迹; 人类; 图 3
Bretin A, Carrière J, Dalmasso G, Bergougnoux A, B chir W, Maurin A, et al. Activation of the EIF2AK4-EIF2A/eIF2?-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection. Autophagy. 2016;12:770-83 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 1b
Crippa V, D Agostino V, Cristofani R, Rusmini P, Cicardi M, Messi E, et al. Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases. Sci Rep. 2016;6:22827 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Jennewein L, Ronellenfitsch M, Antonietti P, Ilina E, Jung J, Stadel D, et al. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget. 2016;7:20016-32 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 1a
Koukourakis M, Kalamida D, Giatromanolaki A, Zois C, Sivridis E, Pouliliou S, et al. Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines. PLoS ONE. 2015;10:e0137675 pubmed 出版商
  • 免疫印迹; 大鼠
  • 免疫印迹; 人类
Cavieres V, González A, Muñoz V, Yefi C, Bustamante H, Barraza R, et al. Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy. PLoS ONE. 2015;10:e0136313 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Macvicar T, Mannack L, Lees R, Lane J. Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells. Int J Mol Sci. 2015;16:13356-80 pubmed 出版商
  • 免疫印迹; 人类; 图 3
García Cano J, Ambroise G, Pascual Serra R, Carrión M, Serrano Oviedo L, Ortega Muelas M, et al. Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance. Oncotarget. 2015;6:15551-65 pubmed
  • 其他; 人类; 1:100; 图 2
  • proximity ligation assay; 人类; 1:100; 图 1
  • 免疫细胞化学; 人类; 1:100; 图 1
  • 免疫印迹; 人类; 1:3000; 图 s3
Gauthier T, Claude Taupin A, Delage Mourroux R, Boyer Guittaut M, Hervouet E. Proximity Ligation In situ Assay is a Powerful Tool to Monitor Specific ATG Protein Interactions following Autophagy Induction. PLoS ONE. 2015;10:e0128701 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Gorbunov N, McDaniel D, Zhai M, Liao P, Garrison B, Kiang J. Autophagy and mitochondrial remodelling in mouse mesenchymal stromal cells challenged with Staphylococcus epidermidis. J Cell Mol Med. 2015;19:1133-50 pubmed 出版商
  • 免疫印迹; 大鼠
  • 免疫印迹; 小鼠
Jaishy B, Zhang Q, Chung H, Riehle C, Soto J, Jenkins S, et al. Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015;56:546-61 pubmed 出版商
  • 免疫印迹; 大鼠
Yang S, Xia C, Li S, Du L, Zhang L, Zhou R. Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity. Redox Biol. 2014;3:63-71 pubmed 出版商
  • 免疫印迹; 人类
Liu J, Zheng L, Ma L, Wang B, Zhao Y, Wu N, et al. Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy. J Nutr Biochem. 2014;25:1154-1160 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1b
Chen K, Wang C, Tsai M, Wu C, Yang H, Chen L, et al. Interconnections between autophagy and the coagulation cascade in hepatocellular carcinoma. Cell Death Dis. 2014;5:e1244 pubmed 出版商
  • 免疫印迹; 人类; 1:3000
Poillet L, Pernodet N, Boyer Guittaut M, Adami P, Borg C, Jouvenot M, et al. QSOX1 inhibits autophagic flux in breast cancer cells. PLoS ONE. 2014;9:e86641 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, et al. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014;10:226-42 pubmed 出版商
  • 免疫印迹; 人类
Lee I, Yun J, Finkel T. The emerging links between sirtuins and autophagy. Methods Mol Biol. 2013;1077:259-71 pubmed 出版商
  • 免疫印迹; 人类
Woessner D, Lim C. Disrupting BCR-ABL in combination with secondary leukemia-specific pathways in CML cells leads to enhanced apoptosis and decreased proliferation. Mol Pharm. 2013;10:270-7 pubmed 出版商
Kim S, Yang C, Lee H, Kim J, Kim Y, Kim Y, et al. ESRRA (estrogen-related receptor α) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Autophagy. 2018;14:152-168 pubmed 出版商
Riffelmacher T, Clarke A, Richter F, Stranks A, Pandey S, Danielli S, et al. Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation. Immunity. 2017;47:466-480.e5 pubmed 出版商
Kim T, Shin Y, Lee H, Kim J, Choe J, Jang J, et al. Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway. Sci Rep. 2017;7:3431 pubmed 出版商
Xie Y, Ma W, Meng J, Ren X. Knockdown of ZFPL1 results in increased autophagy and autophagy‑related cell death in NCI‑N87 and BGC‑823 human gastric carcinoma cell lines. Mol Med Rep. 2017;15:2633-2642 pubmed 出版商
Yang Y, Luo P, Xu H, Dai S, Rao W, Peng C, et al. RNF146 Inhibits Excessive Autophagy by Modulating the Wnt-?-Catenin Pathway in Glutamate Excitotoxicity Injury. Front Cell Neurosci. 2017;11:59 pubmed 出版商
Dos Santos A, Terra L, Wailemann R, Oliveira T, Gomes V, Mineiro M, et al. Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells. BMC Cancer. 2017;17:194 pubmed 出版商
Sun M, Hou L, Tang Y, Liu Y, Wang S, Wang J, et al. Pseudorabies virus infection inhibits autophagy in permissive cells in vitro. Sci Rep. 2017;7:39964 pubmed 出版商
Redmann M, Benavides G, Berryhill T, Wani W, Ouyang X, Johnson M, et al. Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons. Redox Biol. 2017;11:73-81 pubmed 出版商
Kim J, Lee H, Park K, Shin D, Kim T, Kim Y, et al. MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. Autophagy. 2017;13:423-441 pubmed 出版商
Yuan X, Xiao Y, Zhang G, Hou N, Wu X, Chen W, et al. Chloroquine improves left ventricle diastolic function in streptozotocin-induced diabetic mice. Drug Des Devel Ther. 2016;10:2729-37 pubmed 出版商
Jiang P, Zhang P, Mukthavaram R, Nomura N, Pingle S, Teng D, et al. Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells. Oncotarget. 2016;7:57932-57942 pubmed 出版商
Fan G, Yu J, Asare P, Wang L, Zhang H, Zhang B, et al. Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling. J Cell Mol Med. 2016;20:1908-19 pubmed 出版商
Jin H, Hong S, Park J, Chang Y, Hong Y, Park I, et al. Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors. Sci Rep. 2016;6:28945 pubmed 出版商
Gengenbacher M, Nieuwenhuizen N, Vogelzang A, Liu H, Kaiser P, Schuerer S, et al. Deletion of nuoG from the Vaccine Candidate Mycobacterium bovis BCG ?ureC::hly Improves Protection against Tuberculosis. MBio. 2016;7: pubmed 出版商
Hong J, Song Y, Liu Z, Zheng Z, Chen H, Wang S. Anticancer activity of taraxerol acetate in human glioblastoma cells and a mouse xenograft model via induction of autophagy and apoptotic cell death, cell cycle arrest and inhibition of cell migration. Mol Med Rep. 2016;13:4541-8 pubmed 出版商
Cao J, Huang W. Compensatory Increase of Transglutaminase 2 Is Responsible for Resistance to mTOR Inhibitor Treatment. PLoS ONE. 2016;11:e0149388 pubmed 出版商
Yin P, Xu J, He S, Liu F, Yin J, Wan C, et al. Endoplasmic Reticulum Stress in Heat- and Shake-Induced Injury in the Rat Small Intestine. PLoS ONE. 2015;10:e0143922 pubmed 出版商
Bak D, Zhang E, Yi M, Kim D, Lim K, Kim J, et al. High ω3-polyunsaturated fatty acids in fat-1 mice prevent streptozotocin-induced Purkinje cell degeneration through BDNF-mediated autophagy. Sci Rep. 2015;5:15465 pubmed 出版商
Hervouet E, Claude Taupin A, Gauthier T, Perez V, Fraichard A, Adami P, et al. The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models. BMC Cancer. 2015;15:729 pubmed 出版商
Liu H, Ma Y, He H, Wang J, Jiang J, Shao R. SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells. Autophagy. 2015;11:2323-34 pubmed 出版商
Boone B, Orlichenko L, Schapiro N, Loughran P, Gianfrate G, Ellis J, et al. The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer. Cancer Gene Ther. 2015;22:326-34 pubmed 出版商
Li P, Shi J, He Q, Hu Q, Wang Y, Zhang L, et al. Streptococcus pneumoniae induces autophagy through the inhibition of the PI3K-I/Akt/mTOR pathway and ROS hypergeneration in A549 cells. PLoS ONE. 2015;10:e0122753 pubmed 出版商
Morgan A, Hammond V, Sakoh Nakatogawa M, Ohsumi Y, Thomas C, Blanchet F, et al. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biol. 2015;4:40-7 pubmed 出版商
Genevini P, Papiani G, Ruggiano A, Cantoni L, Navone F, Borgese N. Amyotrophic lateral sclerosis-linked mutant VAPB inclusions do not interfere with protein degradation pathways or intracellular transport in a cultured cell model. PLoS ONE. 2014;9:e113416 pubmed 出版商
Puleston D, Zhang H, Powell T, Lipina E, Sims S, Panse I, et al. Autophagy is a critical regulator of memory CD8(+) T cell formation. elife. 2014;3: pubmed 出版商
Renvoisé B, Chang J, Singh R, Yonekawa S, Fitzgibbon E, Mankodi A, et al. Lysosomal abnormalities in hereditary spastic paraplegia types SPG15 and SPG11. Ann Clin Transl Neurol. 2014;1:379-389 pubmed
Assani K, Tazi M, Amer A, Kopp B. IFN-? stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages. PLoS ONE. 2014;9:e96681 pubmed 出版商
Liu K, Shi Y, Guo X, Ouyang Y, Wang S, Liu D, et al. Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria. Cell Death Dis. 2014;5:e1078 pubmed 出版商
Jiang P, Mukthavaram R, Mukthavavam R, Chao Y, Bharati I, Fogal V, et al. Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs. J Transl Med. 2014;12:13 pubmed 出版商
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Martino L, Masini M, Novelli M, Beffy P, Bugliani M, Marselli L, et al. Palmitate activates autophagy in INS-1E ?-cells and in isolated rat and human pancreatic islets. PLoS ONE. 2012;7:e36188 pubmed 出版商
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Ait Mohamed O, Battisti V, Joliot V, Fritsch L, Pontis J, Medjkane S, et al. Acetonic extract of Buxus sempervirens induces cell cycle arrest, apoptosis and autophagy in breast cancer cells. PLoS ONE. 2011;6:e24537 pubmed 出版商
Piras A, Gianetto D, Conte D, Bosone A, Vercelli A. Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure. PLoS ONE. 2011;6:e22514 pubmed 出版商
产品信息
目录号 :
L8918
品牌 :
SIGMA
名称 :
抗LC3在兔生产的抗体
产品类型 :
化学品
名字后缀 :
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
储存 :
-20C
储存温度 :
-20C
物理形态 :
溶液在0.01 M磷酸盐缓冲液, pH值7.4, 含15 mM叠氮化钠
运输的 :
干冰
同义词 :
Anti-MAP1 light chain 3-like protein 1; Anti-MAP1A/1B light chain 3A; Anti-MAP1A/1BLC3; Anti-MAP1A/MAP1B LC3A; Anti-MAP1ALC3; Anti-MAP1BLC3; Anti-MAP1LC3A; Anti-MAP1LC3B; Anti-Microtubule-associated protein 1 light chain 3 alpha; Anti-Microtubule-associated protein 1 light chain 3 beta; Anti-Microtubule-associated proteins 1A/1B light chain 3
unspsc code :
12352203
wgk :
3
形式 :
buffered aqueous solution
抗体形态 :
affinity isolated antibody
应用(s) :
western blot: 1-2 mug/mL using whole extracts of rat and mouse brain; immunoprecipitation: 5-10 mug using extracts of human U87 cells
物种活性 :
小鼠, 人类, 大鼠
浓度 :
~1毫克/毫升
免疫原 :
synthetic peptide corresponding to amino acids 36-49 of human LC3A isoform a, conjugated to KLH via C-terminal cysteine residue. The corresponding sequence is identical in rat and mouse.
分子量 :
antigen mol wt 16-18 kDa
更多信息或购买 :
公司信息
西格玛奥德里奇
上海市徐汇区淮海中路1010号嘉华中心41楼
techservCN@sial.com
http://www.sigmaaldrich.com/china-mainland.html
800-819-3336 400-620-3333 86-21-6141 5566
公司总部: 美国
Sigma-Aldrich是一家在生命科学领域领先的且拥有高科技产品的公司,致力于为生命科学、制药化工等领域提供高质量的服务和产品。