产品简要
公司名称 :
西格玛奥德里奇
其他品牌 :
FLUKA
产品类型 :
抗体
产品名称 :
Monoclonal Anti-MAP Kinase, Activated (Diphosphorylated ERK-1&2) antibody produced in mouse
目录 :
M8159
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
MAPK-YT
反应物种 :
人类, 小鼠, 大鼠, , , 斑马鱼, 果蝇, common platanna, 秀丽隐杆线虫
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 82
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 4c
Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, et al. Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin. EMBO J. 2019;38: pubmed 出版商
  • 免疫印迹; 大鼠; 图 5a
De Pasquale V, Pezone A, Sarogni P, Tramontano A, Schiattarella G, Avvedimento V, et al. EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB. Cell Death Dis. 2018;9:40 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Bostner J, Alayev A, Berman A, Fornander T, Nordenskjold B, Holz M, et al. Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer. Breast Cancer Res Treat. 2018;168:17-27 pubmed 出版商
  • 免疫组化; 小鼠; 图 s5d
Zhao F, Franco H, Rodriguez K, Brown P, Tsai M, Tsai S, et al. Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice. Science. 2017;357:717-720 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 4b
Olivares O, Mayers J, Gouirand V, Torrence M, Gicquel T, Borge L, et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nat Commun. 2017;8:16031 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4d
Szoka L, Karna E, Hlebowicz Sarat K, Karaszewski J, Palka J. Exogenous proline stimulates type I collagen and HIF-1? expression and the process is attenuated by glutamine in human skin fibroblasts. Mol Cell Biochem. 2017;435:197-206 pubmed 出版商
  • 免疫组化; 斑马鱼; 1:500; 图 5I''
Kozlovskaja GumbrienÄ— A, Yi R, Alexander R, Aman A, Jiskra R, Nagelberg D, et al. Proliferation-independent regulation of organ size by Fgf/Notch signaling. elife. 2017;6: pubmed 出版商
  • 免疫印迹; 人类; 表 4
Lopes M, Leal R, Guarnieri R, Schwarzbold M, Hoeller A, Diaz A, et al. A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. Transl Psychiatry. 2016;6:e986 pubmed 出版商
  • 免疫印迹; 果蝇; 1:2000; 图 s8a
Bangi E, Murgia C, Teague A, Sansom O, Cagan R. Functional exploration of colorectal cancer genomes using Drosophila. Nat Commun. 2016;7:13615 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Alekhina O, Marchese A. ?-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4. J Biol Chem. 2016;291:26083-26097 pubmed
  • 免疫印迹; 人类; 图 4b
Greenwood E, Maisel S, Ebertz D, Russ A, Pandey R, SCHROEDER J. Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration. Oncotarget. 2016;7:60776-60792 pubmed 出版商
  • 免疫印迹; common platanna; 1:5000; 图 2f
Tadjuidje E, Kofron M, Mir A, Wylie C, Heasman J, Cha S. Nodal signalling in Xenopus: the role of Xnr5 in left/right asymmetry and heart development. Open Biol. 2016;6: pubmed 出版商
  • 免疫印迹; 人类; 图 7e
Schütz I, López Hernández T, Gao Q, Puchkov D, Jabs S, Nordmeyer D, et al. Lysosomal Dysfunction Caused by Cellular Accumulation of Silica Nanoparticles. J Biol Chem. 2016;291:14170-84 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 2a
Mendel I, Yacov N, Shoham A, Ishai E, Breitbart E. Treatment with Oxidized Phospholipids Directly Inhibits Nonalcoholic Steatohepatitis and Liver Fibrosis Without Affecting Steatosis. Dig Dis Sci. 2016;61:2545-53 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Sakakini N, Turchi L, Bergon A, Holota H, Rekima S, Lopez F, et al. A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells. J Biol Chem. 2016;291:10684-99 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
Morena D, Maestro N, Bersani F, Forni P, Lingua M, Foglizzo V, et al. Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes. elife. 2016;5: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Stefanovic M, Tutusaus A, Martinez Nieto G, Bárcena C, de Gregorio E, Moutinho C, et al. Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma. Oncotarget. 2016;7:8253-67 pubmed 出版商
  • 免疫印迹; 狗; 图 1d
Shukla P, Vogl C, Wallner B, Rigler D, Müller M, Macho Maschler S. High-throughput mRNA and miRNA profiling of epithelial-mesenchymal transition in MDCK cells. BMC Genomics. 2015;16:944 pubmed 出版商
  • 免疫印迹; 果蝇; 1:500
Sun D, Buttitta L. Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila. Development. 2015;142:3033-45 pubmed 出版商
  • 免疫组化-石蜡切片; 果蝇; 1:200; 图 2
Patel P, Dutta D, Edgar B. Niche appropriation by Drosophila intestinal stem cell tumours. Nat Cell Biol. 2015;17:1182-92 pubmed 出版商
  • 免疫印迹; 人类; 图 8
Brohée L, Demine S, Willems J, Arnould T, Colige A, Deroanne C. Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment. Oncotarget. 2015;6:11264-80 pubmed
  • 免疫印迹; 人类; 图 5
Wilson F, Johannessen C, Piccioni F, Tamayo P, Kim J, Van Allen E, et al. A functional landscape of resistance to ALK inhibition in lung cancer. Cancer Cell. 2015;27:397-408 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Guillaumond F, Bidaut G, Ouaissi M, Servais S, Gouirand V, Olivares O, et al. Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma. Proc Natl Acad Sci U S A. 2015;112:2473-8 pubmed 出版商
  • 免疫印迹; 人类; 图 s4
Diesenberg K, Beerbaum M, Fink U, Schmieder P, Krauss M. SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR. J Cell Sci. 2015;128:397-407 pubmed 出版商
  • 免疫组化; 果蝇; 1:200
Matsuoka S, Gupta S, Suzuki E, Hiromi Y, Asaoka M. gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. PLoS ONE. 2014;9:e113423 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014;33:2581-96 pubmed 出版商
  • 免疫印迹; 大鼠; 1:5000
  • 免疫印迹; 小鼠; 1:5000
Zeldich E, Chen C, Colvin T, Bove Fenderson E, Liang J, Tucker Zhou T, et al. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014;289:24700-15 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Martínez Pinilla E, Reyes Resina I, Oñatibia Astibia A, Zamarbide M, Ricobaraza A, Navarro G, et al. CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum. Exp Neurol. 2014;261:44-52 pubmed 出版商
  • 免疫印迹; 人类
Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, et al. The docking protein FRS2? is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A. 2014;111:5514-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4a
Guerra M, Wauson E, McGlynn K, Cobb M. Muscarinic control of MIN6 pancreatic ? cells is enhanced by impaired amino acid signaling. J Biol Chem. 2014;289:14370-9 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5
Bölck B, Ibrahim M, Steinritz D, Morguet C, Dühr S, Suhr F, et al. Detection of key enzymes, free radical reaction products and activated signaling molecules as biomarkers of cell damage induced by benzo[a]pyrene in human keratinocytes. Toxicol In Vitro. 2014;28:875-84 pubmed 出版商
  • 免疫印迹; 人类
Fernandez Estevez M, Casarejos M, Lopez Sendon J, Garcia Caldentey J, Ruiz C, Gomez A, et al. Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition. PLoS ONE. 2014;9:e90202 pubmed 出版商
  • 免疫印迹; 牛; 图 5, 6
Turner M, Cronin J, Healey G, Sheldon I. Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1, and TLR6. Endocrinology. 2014;155:1453-65 pubmed 出版商
  • 免疫印迹; 人类
Zaganjor E, Osborne J, Weil L, Díaz Martínez L, Gonzales J, Singel S, et al. Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene. 2014;33:5457-66 pubmed 出版商
Majorini M, Manenti G, Mano M, De Cecco L, Conti A, Pinciroli P, et al. cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells. Cell Death Differ. 2018;25:2147-2164 pubmed 出版商
Guerra M, Kalwat M, McGlynn K, Cobb M. Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis. FEBS Open Bio. 2017;7:174-186 pubmed 出版商
Schmukler E, Wolfson E, Elazar Z, Kloog Y, Pinkas Kramarski R. Continuous treatment with FTS confers resistance to apoptosis and affects autophagy. PLoS ONE. 2017;12:e0171351 pubmed 出版商
Peterse E, Cleven A, de Jong Y, Briaire de Bruijn I, Fletcher J, Danen E, et al. No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone. BMC Cancer. 2016;16:475 pubmed 出版商
Filippi S, Barnes C, Kirk P, Kudo T, Kunida K, McMahon S, et al. Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling. Cell Rep. 2016;15:2524-35 pubmed 出版商
Ferenczi E, Vierock J, Atsuta Tsunoda K, Tsunoda S, Ramakrishnan C, Gorini C, et al. Optogenetic approaches addressing extracellular modulation of neural excitability. Sci Rep. 2016;6:23947 pubmed 出版商
Bhargava A, Anant M, Mack H. Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. elife. 2016;5: pubmed 出版商
Ryu H, Chung M, DobrzyÅ„ski M, Fey D, Blum Y, Lee S, et al. Frequency modulation of ERK activation dynamics rewires cell fate. Mol Syst Biol. 2015;11:838 pubmed 出版商
Van Boxtel A, Chesebro J, Heliot C, Ramel M, Stone R, Hill C. A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain. Dev Cell. 2015;35:175-85 pubmed 出版商
Wauson E, Guerra M, Dyachok J, McGlynn K, Giles J, Ross E, et al. Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells. Mol Endocrinol. 2015;29:1114-22 pubmed 出版商
Abraham S, Scarcia M, Bagshaw R, McMahon K, Grant G, Harvey T, et al. A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. Nat Commun. 2015;6:7286 pubmed 出版商
Wijayagunawardane M, Hambruch N, Haeger J, Pfarrer C. Effect of epidermal growth factor (EGF) on the phosphorylation of mitogen-activated protein kinase (MAPK) in the bovine oviduct in vitro: Alteration by heat stress. J Reprod Dev. 2015;61:383-9 pubmed 出版商
Wiemhoefer A, Stargardt A, van der Linden W, Renner M, Van Kesteren R, Stap J, et al. Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2. Mol Cell Proteomics. 2015;14:2177-93 pubmed 出版商
Schmid T, Snoek L, Fröhli E, van der Bent M, Kammenga J, Hajnal A. Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA. PLoS Genet. 2015;11:e1005236 pubmed 出版商
Preta G, Lotti V, Cronin J, Sheldon I. Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes. FASEB J. 2015;29:1516-28 pubmed 出版商
Tenin G, Clowes C, Wolton K, Krejci E, Wright J, Lovell S, et al. Erbb2 is required for cardiac atrial electrical activity during development. PLoS ONE. 2014;9:e107041 pubmed 出版商
Truscott M, Islam A, Lightfoot J, Lopez Bigas N, Frolov M. An intronic microRNA links Rb/E2F and EGFR signaling. PLoS Genet. 2014;10:e1004493 pubmed 出版商
Minna E, Romeo P, De Cecco L, Dugo M, Cassinelli G, Pilotti S, et al. miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma. Oncotarget. 2014;5:2513-28 pubmed
Grepin R, Ambrosetti D, Marsaud A, Gastaud L, Amiel J, Pedeutour F, et al. The relevance of testing the efficacy of anti-angiogenesis treatments on cells derived from primary tumors: a new method for the personalized treatment of renal cell carcinoma. PLoS ONE. 2014;9:e89449 pubmed 出版商
Ashton Beaucage D, Udell C, Gendron P, Sahmi M, Lefrancois M, Baril C, et al. A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila. PLoS Biol. 2014;12:e1001809 pubmed 出版商
Yoshihara D, Kugita M, Sasaki M, Horie S, Nakanishi K, Abe T, et al. Telmisartan ameliorates fibrocystic liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. PLoS ONE. 2013;8:e81480 pubmed 出版商
Eberhard R, Stergiou L, Hofmann E, Hofmann J, Haenni S, Teo Y, et al. Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003943 pubmed 出版商
Johannessen C, Johnson L, Piccioni F, Townes A, Frederick D, Donahue M, et al. A melanocyte lineage program confers resistance to MAP kinase pathway inhibition. Nature. 2013;504:138-42 pubmed 出版商
de Souza W, Fortunato Miranda N, Robbs B, de Araujo W, de Freitas Junior J, Bastos L, et al. Claudin-3 overexpression increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling. PLoS ONE. 2013;8:e74994 pubmed 出版商
Friedman S, Dani N, Rushton E, Broadie K. Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila. Dis Model Mech. 2013;6:1400-13 pubmed 出版商
Neutelings T, Lambert C, Nusgens B, Colige A. Effects of mild cold shock (25°C) followed by warming up at 37°C on the cellular stress response. PLoS ONE. 2013;8:e69687 pubmed 出版商
Guzman Y, Tronson N, Jovasevic V, Sato K, Guedea A, Mizukami H, et al. Fear-enhancing effects of septal oxytocin receptors. Nat Neurosci. 2013;16:1185-7 pubmed 出版商
Ramel M, Hill C. The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Dev Biol. 2013;378:170-82 pubmed 出版商
Accornero P, Miretti S, Bersani F, Quaglino E, Martignani E, Baratta M. Met receptor acts uniquely for survival and morphogenesis of EGFR-dependent normal mammary epithelial and cancer cells. PLoS ONE. 2012;7:e44982 pubmed 出版商
Willoughby L, Schlosser T, Manning S, Parisot J, Street I, Richardson H, et al. An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery. Dis Model Mech. 2013;6:521-9 pubmed 出版商
Nakdimon I, Walser M, Fröhli E, Hajnal A. PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development. PLoS Genet. 2012;8:e1002881 pubmed 出版商
Kabara E, Coussens P. Infection of Primary Bovine Macrophages with Mycobacterium avium Subspecies paratuberculosis Suppresses Host Cell Apoptosis. Front Microbiol. 2012;3:215 pubmed 出版商
Magudia K, Lahoz A, Hall A. K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc. J Cell Biol. 2012;198:185-94 pubmed 出版商
Valluet A, Hmitou I, Davis S, Druillennec S, Larcher M, Laroche S, et al. B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse. PLoS ONE. 2010;5:e15272 pubmed 出版商
Ludwig A, Otto G, Riento K, Hams E, Fallon P, Nichols B. Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment. J Cell Biol. 2010;191:771-81 pubmed 出版商
Danovi D, Cremona C, Machado da Silva G, Basu S, Noon L, Parrinello S, et al. A genetic screen for anchorage-independent proliferation in mammalian cells identifies a membrane-bound neuregulin. PLoS ONE. 2010;5:e11774 pubmed 出版商
Javle M, Shroff R, Xiong H, Varadhachary G, Fogelman D, Reddy S, et al. Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies. BMC Cancer. 2010;10:368 pubmed 出版商
Siekhaus D, Haesemeyer M, Moffitt O, Lehmann R. RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila. Nat Cell Biol. 2010;12:605-10 pubmed 出版商
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Mazurkiewicz P, Thomas J, Thompson J, Liu M, Arbibe L, Sansonetti P, et al. SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases. Mol Microbiol. 2008;67:1371-83 pubmed 出版商
Hayashi M, Chin G, Villeneuve A. C. elegans germ cells switch between distinct modes of double-strand break repair during meiotic prophase progression. PLoS Genet. 2007;3:e191 pubmed
Cadd V, Hogg P, Harris A, Feller S. Molecular profiling of signalling proteins for effects induced by the anti-cancer compound GSAO with 400 antibodies. BMC Cancer. 2006;6:155 pubmed
Wellbrock C, Marais R. Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation. J Cell Biol. 2005;170:703-8 pubmed
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Brockbank E, Bridges J, Marshall C, Sahai E. Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo. Br J Cancer. 2005;92:102-12 pubmed
Cha H, Shapiro P. Tyrosine-phosphorylated extracellular signal--regulated kinase associates with the Golgi complex during G2/M phase of the cell cycle: evidence for regulation of Golgi structure. J Cell Biol. 2001;153:1355-67 pubmed
Kulkarni S, Gish G, van der Geer P, Henkemeyer M, Pawson T. Role of p120 Ras-GAP in directed cell movement. J Cell Biol. 2000;149:457-70 pubmed
产品信息
目录号 :
M8159
品牌 :
SIGMA
名称 :
Monoclonal Anti-MAP Kinase, Activated (Diphosphorylated ERK-1&2) antibody produced in mouse
产品类型 :
化学品
名字后缀 :
clone MAPK-YT, ascites fluid
储存 :
-20C
储存温度 :
-20C
运输的 :
干冰
同义词 :
Monoclonal Anti-MAP Kinase, Activated (Diphosphorylated ERK-1&2)
unspsc code :
12352203
wgk :
3
抗体形态 :
ascites fluid
应用(s) :
immunoprecipitation: suitable; indirect ELISA: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; immunocytochemistry: suitable; western blot: 1:10,000 using rat brain extract
物种活性 :
酵母, 蛙, 人类, 大鼠, 牛, 秀丽隐杆线虫, 果蝇, 小鼠, 仓鼠
免疫原 :
synthetic peptide HTGFLpTEpYVAT corresponding to the phosphorylated form of the ERK-activation loop.
克隆 :
MAPK-YT
分子量 :
antigen ERK-1 mol wt 44 kDa; antigen ERK-2 mol wt 42 kDa
更多信息或购买 :
公司信息
西格玛奥德里奇
上海市徐汇区淮海中路1010号嘉华中心41楼
techservCN@sial.com
http://www.sigmaaldrich.com/china-mainland.html
800-819-3336 400-620-3333 86-21-6141 5566
公司总部: 美国
Sigma-Aldrich是一家在生命科学领域领先的且拥有高科技产品的公司,致力于为生命科学、制药化工等领域提供高质量的服务和产品。