蛋白

Tau-441 (244-372) Protein

T08-55N

20微克/50微克

145/305美元

Tau-441 (244-372) Protein

tau蛋白

大肠杆菌

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20微克/50微克

145/305美元

P10636-8

Recombinant human tag-free Tau-441 (244-372) was expressed in E. coli cells.

人类

Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).

Tau-F, (N2R4), Tau-4, MAPT, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, FLJ31424, MGC138549

>95%

50mM三羟甲基氨基甲烷氯化氢, pH值7.5, 150mM氯化钠, 0.25mM DTT, 0.1mM苯甲基磺酰氟, 25% 甘油

干冰

0.2微克/微升

Kinase Assay, Western Blot

Store product at –70ºC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.