产品简要
公司名称 :
St John's Laboratory
产品类型 :
抗体
产品名称 :
Anti-Cleaved-Notch 1 (V1754) antibody
目录 :
STJ90066
规格 :
100μl
价格 :
150美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
图像
图像 1 :
Western blot (WB) analysis of Cleaved-Notch 1 (V1754) Polyclonal Antibody.
产品信息
目录代码 :
STJ90066
产品名称 :
Anti-Cleaved-Notch 1 (V1754) antibody
产品类型 :
一抗
宿主物种 :
兔
克隆性 :
多克隆
共轭 :
未共轭
抗原修饰 :
切断的
抗体亚型 :
IgG
规格 :
100μl
标价 :
150美元
产品描述 :
Notch 1 is a protein encoded by the NOTCH1 gene which is approximately 272,5 kDa. Notch 1 is localised to the cell membrane. It is involved in the notch signalling pathway and Notch 2 activation and transmission of signal to the nucleus. It functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch 1 is expressed in most adult tissues but is found mainly in lymphoid tissues. Mutations in the NOTCH1 gene may result in aortic valve disease and Adams-Oliver syndrome. STJ90066 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment of activated Notch 1 protein resulting from cleavage adjacent to V1754.
交叉活性 :
人类, 小鼠, 大鼠
别名 :
NOTCH1 antibody, TAN1 antibody, Neurogenic locus notch homolog protein 1 antibody, Notch 1 antibody, hN1 antibody, Translocation-associated notch protein TAN-1 antibody, Notch 1 extracellular truncation antibody, NEXT antibody, Notch 1 intracellular domain antibody, NICD antibody, Cleaved-Notch 1 (V1754) antibody
免疫原 :
Synthesized peptide derived from human Notch 1
表位 :
1710-1790氨基酸, 内部
定位 :
Cell membrane ; Notch 1 intracellular domain: Nucleus Note=Following proteolytical processing NICD is translocated to the nucleus.
特异性 :
Cleaved-Notch 1 (V1754) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 1 protein resulting from cleavage adjacent to V1754.
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
缓冲液 :
液体PBS含50% 甘油, 0.5% BSA
防腐剂 :
0.02% 叠氮化钠
浓度 :
1毫克/毫升
应用摘要 :
免疫印迹, 酶联免疫吸附测定
储存 :
Store at -20°C, and avoid repeat freeze-thaw cycles.
更多信息或购买 :
公司信息
St John's Laboratory
Unit 31, 35 Evelyn Street
London, SE8 5RT
London, SE8 5RT
info@stjohnslabs.com
www.stjohnslabs.com44-0-207-232-2321
公司总部: 英国