产品简要
公司名称 :
St John's Laboratory
产品类型 :
抗体
产品名称 :
Anti-Phospho-p70 S6 kinase α (S447) antibody
目录 :
STJ90374
规格 :
100μl
价格 :
150美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
抗原修饰 :
磷酸化
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化-石蜡切片
更多信息或购买 :
图像
图像 1 :
St John's Laboratory STJ90374 图像 1
Western Blot (WB) analysis of specific cells using Phospho-p70 S6 kinase alpha (S447) Polyclonal Antibody.
产品信息
目录代码 :
STJ90374
产品名称 :
Anti-Phospho-p70 S6 kinase α (S447) antibody
产品类型 :
一抗
宿主物种 :
克隆性 :
多克隆
共轭 :
未共轭
抗原修饰 :
磷酸化
抗体亚型 :
IgG
规格 :
100μl
标价 :
150美元
产品描述 :
Phospho-p70 S6 kinase alpha is a protein encoded by the RPS6KB1 gene which is approximately 59,2 kDa. Phospho-p70 S6 kinase alpha is localised to the mitochondrion and cell junctions. It is involved in pathways such as the common cytokine receptor gamma-c family signalling pathway, regulation of lipid metabolism insulin signalling-generic cascades, RET signalling and mTOR signalling. This protein falls under the ribosomal S6 kinase family of serine/threonine kinases. It responds to mTOR signalling and is activated in response to growth factors and nutrients to promote protein synthesis, cell growth, cell cycle progression and cell proliferation. It regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Phospho-p70 S6 kinase alpha is expressed in the cells of the eye, nervous system, muscle, heart and liver. Mutations in the RPS6KB1 gene result in diseases such as tuberous sclerosis which manifests as hamartoma formation in multiple organ systems and glioblastoma multiforme which is a central nervous system tumour of grade IV histological malignancy. STJ90374 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. The synthesized peptide derived from human p70 S6 kinase alpha around the phosphorylation site of S447. This primary antibody specifically binds to endogenous p70 S6 kinase α protein which only binds about S447 when S447 is phosphorylated.
交叉活性 :
人类, 小鼠, 大鼠
别名 :
RPS6KB1 antibody, STK14A antibody, Ribosomal protein S6 kinase beta-1 antibody, S6K-beta-1 antibody, S6K1 antibody, 70 kDa ribosomal protein S6 kinase 1 antibody, P70S6K1 antibody, p70-S6K 1 antibody, Ribosomal protein S6 kinase I antibody, Serine/threonine-protein kinase 14A antibody, p70 ribosomal S6 kinase alpha antibody, p70 S6 kinase alpha antibody, p70 S6K-alpha antibody, p70 S6KA antibody, Phospho-p70 S6 kinase α (S447) antibody
免疫原 :
Synthesized peptide derived from human p70 S6 kinase α around the phosphorylation site of S447.
表位 :
390-470氨基酸
定位 :
Cell junction, synapse, synaptosome Mitochondrion outer membrane. Mitochondrion. Note=Colocalizes with URI1 at mitochondrion.; Isoform Alpha I: Nucleus. Cytoplasm.; Isoform Alpha II: Cytoplasm.
特异性 :
Phospho-p70 S6 kinase α (S447) Polyclonal Antibody detects endogenous levels of p70 S6 kinase α protein only when phosphorylated at S447.
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
缓冲液 :
液体PBS含50% 甘油, 0.5% BSA
防腐剂 :
0.02% 叠氮化钠
浓度 :
1毫克/毫升
应用摘要 :
免疫印迹, 免疫组化-p, 酶联免疫吸附测定
储存 :
Store at -20°C, and avoid repeat freeze-thaw cycles.
更多信息或购买 :
公司信息
St John's Laboratory
Unit 31, 35 Evelyn Street
London, SE8 5RT
info@stjohnslabs.com
www.stjohnslabs.com
44-0-207-232-2321
公司总部: 英国