产品简要
公司名称 :
St John's Laboratory
产品类型 :
抗体
产品名称 :
抗磷酸化IκB-α(Y305)抗体
目录 :
STJ90912
规格 :
100μl
价格 :
150美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
nonconjugated
抗原修饰 :
磷酸化
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化-石蜡切片
更多信息或购买 :
St John's Laboratory 产品网页
图像
图像 1 :
St John's Laboratory STJ90912 图像 1
Immunohistochemical analysis of paraffin-embedded Human lung cancer. Antibody was diluted at 1:100 (4°,overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antibody retrieval. Negative control (right) obtained from antibody was pre-absorbed by immunogen peptide.
产品信息
目录代码 :
STJ90912
产品名称 :
抗磷酸化IκB-α(Y305)抗体
产品类型 :
一抗
宿主物种 :
兔
克隆性 :
多克隆
共轭 :
未共轭
抗原修饰 :
磷酸化
抗体亚型 :
IgG
规格 :
100μl
标价 :
150美元
产品描述 :
IκB-α is a protein encoded by the NFKBIA gene which is approximately 35,6 kDa. IκB-α is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the TNFR1 pathway, the 4-1BB pathway and toll-like receptor signalling pathways. This protein falls under the NF-kappa-B inhibitor family. Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals, this process is involved in inflammatory responses. IκB-α is induced in adherent monocytes. Mutations in the NFKBIA gene may result in ectodermal dysplasia with T-cell immunodeficiency. STJ90912 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous IκB-α protein which only binds about Y305 when Y305 is phosphorylated.
交叉活性 :
Human, Mouse, Rat, Monkey
别名 :
NFKBIA antibody, IKBA antibody, MAD3 antibody, NFKBI antibody, NF-kappa-B inhibitor alpha antibody, I-kappa-B-alpha antibody, IkB-alpha antibody, IkappaBalpha antibody, Major histocompatibility complex enhancer-binding protein MAD3 antibody, Phospho-IκB-α (Y305) antibody
免疫原 :
Synthesized peptide derived from human IκB-α around the phosphorylation site of Y305.
表位 :
240-320氨基酸
定位 :
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
特异性 :
Phospho-IκB-α (Y305) Polyclonal Antibody detects endogenous levels of IκB-α protein only when phosphorylated at Y305.
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
缓冲液 :
液体PBS含50% 甘油, 0.5% BSA
防腐剂 :
0.02% 叠氮化钠
浓度 :
1毫克/毫升
应用摘要 :
免疫印迹, 免疫组化-p, 酶联免疫吸附测定
储存 :
Store at -20°C, and avoid repeat freeze-thaw cycles.
更多信息或购买 :
St John's Laboratory 产品网页
公司信息
St John's Laboratory
Unit 31, 35 Evelyn Street
London, SE8 5RT
info@stjohnslabs.com
www.stjohnslabs.com
44-0-207-232-2321
公司总部: 英国