抗体

抗磷酸化IRF(S385)抗体

STJ91040

100μl

150美元

多克隆

兔

nonconjugated

磷酸化

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫组化-石蜡切片

抗磷酸化IRF(S385)抗体

一抗

兔

多克隆

未共轭

磷酸化

IgG

100μl

150美元

IRF-3 is a protein encoded by the IRF3 gene which is approximately 47,2 kDa. IRF-3 is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling and toll-like receptor signalling pathway. This protein falls under the interferon regulatory transcription factor family. It is found in an inactive form in the cytoplasm that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex is then translocated to the nucleus where it activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. IRF-3 is expressed constitutively in a variety of tissues. Mutations in the IRF3 gene may be involved in herpes simplex encephalitis. STJ91040 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous IRF-3 protein which only binds about S385 when S385 is phosphorylated.

人类

IRF3抗体, 干扰素调节因子3抗体, IRF-3抗体, 磷酸化IRF(S385)抗体

Synthesized peptide derived from human IRF-3 around the phosphorylation site of S385.

320-400氨基酸

Cytoplasm Nucleus Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

Phospho-IRF-3 (S385) Polyclonal Antibody detects endogenous levels of IRF-3 protein only when phosphorylated at S385.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

液体PBS含50% 甘油, 0.5% BSA

0.02% 叠氮化钠

1毫克/毫升

免疫印迹, 免疫组化-p, IF, 酶联免疫吸附测定

Store at -20°C, and avoid repeat freeze-thaw cycles.