产品简要
公司名称 :
St John's Laboratory
产品类型 :
抗体
产品名称 :
抗HIF-1α抗体
目录 :
STJ93498
规格 :
100μl
价格 :
150美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化-石蜡切片
更多信息或购买 :
图像
图像 1 :
St John's Laboratory STJ93498 图像 1
Western blot (WB) analysis of HIF-1alpha Polyclonal Antibody.
产品信息
目录代码 :
STJ93498
产品名称 :
抗HIF-1α抗体
产品类型 :
一抗
宿主物种 :
克隆性 :
多克隆
共轭 :
未共轭
抗体亚型 :
IgG
规格 :
100μl
标价 :
150美元
产品描述 :
HIF-1α is a protein encoded by the HIF1A gene which is approximately 92, 6 kDa. HIF-1α is localised to the cytoplasm and nucleus. It is involved in CDK-mediated phosphorylation, removal of Cdc6, HIF repressor pathways, signalling by PTK6 and the notch signalling pathway. It functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1α is expressed in most tissues with highest levels in kidney and heart. Mutations in the HIF1A gene may result in hypoxia and retinal ischemia. STJ93498 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of HIF-1α protein.
交叉活性 :
人类, 小鼠, 大鼠
别名 :
HIF1A antibody, BHLHE78 antibody, MOP1 antibody, PASD8 antibody, Hypoxia-inducible factor 1-alpha antibody, HIF-1-alpha antibody, HIF1-alpha antibody, ARNT-interacting protein antibody, Basic-helix-loop-helix-PAS protein MOP1 antibody, Class E basic helix-loop-helix protein 78 antibody, bHLHe78 antibody, Member of PAS protein 1 antibody, PAS domain-containing protein 8 antibody
免疫原 :
Synthesized peptide derived from human HIF-1α.
表位 :
内部
定位 :
Cytoplasm Nucleus Nucleus speckle Note=Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia .
特异性 :
HIF-1α多克隆抗体检测内生水平HIF-1α蛋白
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
缓冲液 :
液体PBS含50% 甘油, 0.5% BSA
防腐剂 :
0.02% 叠氮化钠
浓度 :
1毫克/毫升
应用摘要 :
免疫印迹, 免疫组化-p, 酶联免疫吸附测定
储存 :
Store at -20°C, and avoid repeat freeze-thaw cycles.
更多信息或购买 :
公司信息
St John's Laboratory
Unit 31, 35 Evelyn Street
London, SE8 5RT
info@stjohnslabs.com
www.stjohnslabs.com
44-0-207-232-2321
公司总部: 英国