产品简要
公司名称 :
St John's Laboratory
产品类型 :
抗体
产品名称 :
抗核纤层蛋白A/C抗体
目录 :
STJ93885
规格 :
100μl
价格 :
150美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
图像
图像 1 :
St John's Laboratory STJ93885 图像 1
Western blot (WB) analysis of Lamin A/C Polyclonal Antibody.
产品信息
目录代码 :
STJ93885
产品名称 :
抗核纤层蛋白A/C抗体
产品类型 :
一抗
宿主物种 :
克隆性 :
多克隆
共轭 :
未共轭
抗体亚型 :
IgG
规格 :
100μl
标价 :
150美元
产品描述 :
Lamin A/C is a protein encoded by the LMNA gene which is approximately 74,1 kDa. Lamin A/C is localised to the nucleus and nuclear envelope. It is involved in the apoptosis and survival caspase cascade, mitotic cell cycle, unfolded protein response and arrhythmogenic right ventricular cardiomyopathy. It plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics and is required for normal development of the peripheral nervous system and skeletal muscle. It is also required for osteoblasto genesis and bone formation. Lamin A/C is expressed in the arteries. Mutations in the LMNA gene can result in Emery-Dreifuss muscular dystrophy 2. The antibody STJ93885 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at S392.
交叉活性 :
人类, 小鼠, 大鼠
别名 :
LMNA antibody, LMN1 antibody, Prelamin-A/C antibody, Lamin-A/C antibody, 70 kDa lamin antibody, Renal carcinoma antigen NY-REN-32 antibody
免疫原 :
Synthesized peptide derived from human Lamin A/C around the non-phosphorylation site of S392.
表位 :
330-410氨基酸
定位 :
Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.; Isoform C: Nucleus speckle
特异性 :
核纤层蛋白A/C多克隆抗体检测内生水平核纤层蛋白A/C蛋白
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
缓冲液 :
液体PBS含50% 甘油, 0.5% BSA
防腐剂 :
0.02% 叠氮化钠
浓度 :
1毫克/毫升
应用摘要 :
免疫印迹, 免疫组化-p, IF, 酶联免疫吸附测定
储存 :
Store at -20°C, and avoid repeat freeze-thaw cycles.
更多信息或购买 :
公司信息
St John's Laboratory
Unit 31, 35 Evelyn Street
London, SE8 5RT
info@stjohnslabs.com
www.stjohnslabs.com
44-0-207-232-2321
公司总部: 英国