St John's Laboratory
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫组化-石蜡切片
图像 1 :
Western Blot (WB) analysis of specific cells using Neu Polyclonal Antibody.
Neu is a protein encoded by the ERBB2 gene which is approximately 137,9 kDa. Neu isoform 1 is localised to the cell membrane and isoform 2 and 3 are localised to the nucleus and cytoplasm. It is involved in RET signalling, the GPCR pathway, signalling by ERBB2 and glioma. It is a protein tyrosine kinase that is part of several cell surface receptor complexes. It has no ligand binding domain of its own and therefore cannot bind growth factors. It however does bind to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways. Neu is expressed in a variety of tumor tissues including primary breast tumors. Mutations in the ERBB2 gene may result in lung cancer and ovarian cancer. STJ94412 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Neu protein.
人类, 小鼠, 大鼠
ERBB2 antibody, HER2 antibody, MLN19 antibody, NEU antibody, NGL antibody, Receptor tyrosine-protein kinase erbB-2 antibody, Metastatic lymph node gene 19 protein antibody, MLN 19 antibody, Proto-oncogene Neu antibody, Proto-oncogene c-ErbB-2 antibody, Tyrosine kinase-type cell surface receptor HER2 antibody, p185erbB2 antibody, CD antigen CD340 antibody
Synthesized peptide derived from human Neu
Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.; Isoform 2: Cytoplasm. Nucleus.; Isoform 3: Cytoplasm. Nucleus.
Neu Polyclonal Antibody detects endogenous levels of Neu protein.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
液体PBS含50% 甘油, 0.5% BSA
免疫印迹, 免疫组化-p, IF, 酶联免疫吸附测定
Store at -20°C, and avoid repeat freeze-thaw cycles.