产品简要
公司名称 :
St John's Laboratory
产品类型 :
抗体
产品名称 :
Anti-Neu antibody
目录 :
STJ94412
规格 :
100μl
价格 :
150美元
克隆性 :
多克隆
宿主 :
共轭标签 :
nonconjugated
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
图像
图像 1 :
St John's Laboratory STJ94412 图像 1
Western Blot (WB) analysis of specific cells using Neu Polyclonal Antibody.
产品信息
目录代码 :
STJ94412
产品名称 :
Anti-Neu antibody
产品类型 :
一抗
宿主物种 :
克隆性 :
多克隆
共轭 :
未共轭
抗体亚型 :
IgG
规格 :
100μl
标价 :
150美元
产品描述 :
Neu is a protein encoded by the ERBB2 gene which is approximately 137,9 kDa. Neu isoform 1 is localised to the cell membrane and isoform 2 and 3 are localised to the nucleus and cytoplasm. It is involved in RET signalling, the GPCR pathway, signalling by ERBB2 and glioma. It is a protein tyrosine kinase that is part of several cell surface receptor complexes. It has no ligand binding domain of its own and therefore cannot bind growth factors. It however does bind to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways. Neu is expressed in a variety of tumor tissues including primary breast tumors. Mutations in the ERBB2 gene may result in lung cancer and ovarian cancer. STJ94412 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Neu protein.
交叉活性 :
人类, 小鼠, 大鼠
别名 :
ERBB2 antibody, HER2 antibody, MLN19 antibody, NEU antibody, NGL antibody, Receptor tyrosine-protein kinase erbB-2 antibody, Metastatic lymph node gene 19 protein antibody, MLN 19 antibody, Proto-oncogene Neu antibody, Proto-oncogene c-ErbB-2 antibody, Tyrosine kinase-type cell surface receptor HER2 antibody, p185erbB2 antibody, CD antigen CD340 antibody
免疫原 :
Synthesized peptide derived from human Neu
表位 :
610-690氨基酸, 内部
定位 :
Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.; Isoform 2: Cytoplasm. Nucleus.; Isoform 3: Cytoplasm. Nucleus.
特异性 :
Neu Polyclonal Antibody detects endogenous levels of Neu protein.
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
缓冲液 :
液体PBS含50% 甘油, 0.5% BSA
防腐剂 :
0.02% 叠氮化钠
浓度 :
1毫克/毫升
应用摘要 :
免疫印迹, 免疫组化-p, IF, 酶联免疫吸附测定
储存 :
Store at -20°C, and avoid repeat freeze-thaw cycles.
更多信息或购买 :
公司信息
St John's Laboratory
Unit 31, 35 Evelyn Street
London, SE8 5RT
info@stjohnslabs.com
www.stjohnslabs.com
44-0-207-232-2321
公司总部: 英国