产品简要
公司名称 :
StressMarq Biosciences
产品类型 :
抗体
产品名称 :
PSD95抗体
目录 :
SMC-122D
规格 :
100微克
价格 :
278.00美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
6G6
反应物种 :
人类, 小鼠, 大鼠, 牛
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
StressMarq Biosciences 产品网页
产品信息
目录号 :
SMC-122D
产品名称 :
PSD95抗体
描述 :
小鼠抗大鼠PSD95单克隆IgG2a
靶标 :
PSD95
共轭标签 :
未共轭
2021标价 :
278.00美元
Currency :
美元
研究领域(s) :
Neuroscience Cell Markers Neuron Markers Postsynaptic Markers Cell Signaling Organelle Markers
别称(s) :
PSD 95 Antibody, PSD-95 Antibody, DLG4 Antibody, SAP90 Antibody, Synapse-associated protein 90 Antibody, Postsynaptic density protein 95 Antibody, Disks large homolog 4 Antibody
规格 :
100微克
类别 :
抗体
产品类型 :
单克隆
克隆编号 :
6G6
免疫原 :
重组大鼠PSD-95
免疫原物种 :
大鼠
登录号 :
NP_062567.1
Swiss Prot数据库 :
P31016
应用 :
免疫印迹免疫组化免疫细胞化学/IF艾姆斯氏试验
宿主物种 :
小鼠
抗体亚型 :
IgG2a
物种活性缩写 :
Hu Ms Rt Bv
物种活性全称 :
人类小鼠大鼠牛
抗体稀释 :
WB (1:250), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
纯化 :
蛋白质G纯化
储存缓冲液 :
PBS pH7.4, 50% 甘油, 0.09% 叠氮化钠
浓度 :
1毫克/毫升
特异性 :
Detects ~100kDa. An additional protein of >100kDa is also detected. Additional cross-reactive bands are detected at ~75kDa and 50kDa in rat and mouse samples.
储存温度 :
-20ºC
运输温度 :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-122D, RRID: AB_2300386
化验分析证明书 :
1 µg/ml was sufficient for detection of PSD-95 on 20 µg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse IgG: HRP as the secondary.
Cellular Localization :
Cell Membrane Cell Junction Synapse Postsynaptic Cell Membrane Postsynaptic Density Cell Projection Axon
科研背景 :
Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3, 4). PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD95 are associated with autism (7).
参考文献 :
1. Chetkovich D.M., Bunn R.C., Kuo S.H., Kawasaki Y., Kohwi M., and Bredt D.S. (2002) J Neurosci. 22(15): 6415-25. 2. Cao J., Viholainen J.I., Dart C., Warwick H.K., Levland M.L. and Courtney M.J. (2005) J Cell Biol. 168(1): 117-26. 3. Kennedy M. (1997) Trends in Neurosci. 6: 264-268. 4. Irie M. et al. (1997) Science 277(5331): 1511-5. 5. Cai C. et al. (2006) J Biol Chem. 281: 4267-73. 6. Yao W.D. et al. (2004) Neuron 41: 625-38. 7. Cline H. (2005) Curr Biol. 15: R203-5.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-122_PSD95_Antibody_6G6_ICC-IF_Human_HaCaT-cells_1.png SMC-122_PSD95_Antibody_6G6_ICC-IF_Rat_dissociated-hippocampal-neurons_10X_1.png SMC-122_PSD95_Antibody_6G6_WB_Rat_brain-membrane-lysate_1.png
更多信息或购买 :
StressMarq Biosciences 产品网页
公司信息
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
公司总部: 加拿大
StressMarq Biosciences Inc.是由Dr.Louwrier创建与温哥华的维多利亚，专注于热休克、细胞压力、离子通道及细胞信号研究领域，提供大量经过严格验证的抗体、蛋白及试剂盒。公司致力于提供高质量试剂以满足并超越客户期望。它也推出抗体试用项目，特别针对于新的研究领域，鼓励客户在购买之前先测试小规格试用产品。此外，公司提供采用新专利免疫组化技术的试剂盒，采用前所未有的抗体浓度进行实验。