产品简要
公司名称 :
StressMarq Biosciences
产品类型 :
抗体
产品名称 :
p38甲(地图激酶)抗体
目录 :
SMC-152D
规格 :
100微克
价格 :
242.00美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
9F12
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫沉淀
更多信息或购买 :
产品信息
目录号 :
SMC-152D
产品名称 :
p38甲(地图激酶)抗体
描述 :
小鼠抗人类p38甲(地图激酶)单克隆IgG1
靶标 :
p38 MAPK
共轭标签 :
未共轭
2021标价 :
242.00美元
Currency :
美元
研究领域(s) :
Cell Signaling Post-translational Modifications Phosphorylation Cancer
别称(s) :
csaid结合蛋白1抗体, CSBP1抗体, CSBP2抗体, EXIP抗体, 地图激酶MXI2抗体, MAPkinase p38alpha抗体, MAPK14抗体, p38甲抗体, p38 MAP激酶抗体, p丝裂原活化蛋白激酶抗体, RK抗体, SAPK 2A抗体, 应激活化蛋白激酶2a抗体
规格 :
100微克
类别 :
抗体
产品类型 :
单克隆
克隆编号 :
9F12
免疫原 :
全长重组蛋白在大肠杆菌中表达细胞
免疫原物种 :
人类
登录号 :
NP_001306.1
Swiss Prot数据库 :
Q16539
应用 :
免疫印迹免疫组化免疫沉淀酶联免疫吸附测定艾姆斯氏试验
宿主物种 :
小鼠
抗体亚型 :
IgG1
物种活性缩写 :
Hu Ms Rt
物种活性全称 :
人类小鼠大鼠
抗体稀释 :
WB (1:1000), IHC (1:1000); optimal dilutions for assays should be determined by the user.
纯化 :
蛋白质G纯化
储存缓冲液 :
PBS, 50% 甘油, 0.09% 叠氮化钠
浓度 :
1毫克/毫升
特异性 :
Detects ~38kDa.
储存温度 :
-20ºC
运输温度 :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SMC-152D, RRID: AB_2141876
化验分析证明书 :
Detects ~38kDa protein corresponding to p38α MAPK when loaded with 6 ng of purified p38α by chemiluminescent immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cellular Localization :
Cytoplasm Nucleus
科研背景 :
The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2α translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (5). As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).
参考文献 :
1. Pearson, G. et al (2001). Endocrine Reviews 22 (2): 153-183. 2. Fan, Y. et al (2007) Mol. Cells 23 (1): 30-38. 3. Han, J. et al. (1994) Science 265: 808-811. 4. Van, L. A., et al. (2004) Faseb J. 18: 1946−1948. 5. Deng et al. (2003) Cell. 115: 61-70. 6. Salojin KV, et al. (2006) J Immunol. 176 (3):1899-907. 7. Medicherla S. et al. (2006). J Pharmacol Exp Ther.318(1): 99-107.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SMC-152_p38-MAPK_Antibody_9F12_IHC_Mouse_Retinal-Injury-Model_1.png SMC-152_p38-MAPK_Antibody_9F12_IHC_Human_colon-carcinoma_40x_1.png SMC-152_p38-MAPK_Antibody_9F12_WB_Human_Cell-lysates_1.png
更多信息或购买 :
公司信息
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
公司总部: 加拿大
StressMarq Biosciences Inc.是由Dr.Louwrier创建与温哥华的维多利亚,专注于热休克、细胞压力、离子通道及细胞信号研究领域,提供大量经过严格验证的抗体、蛋白及试剂盒。公司致力于提供高质量试剂以满足并超越客户期望。它也推出抗体试用项目,特别针对于新的研究领域,鼓励客户在购买之前先测试小规格试用产品。此外,公司提供采用新专利免疫组化技术的试剂盒,采用前所未有的抗体浓度进行实验。