产品简要
公司名称 :
StressMarq Biosciences
产品类型 :
抗体
产品名称 :
GRP78抗体
目录 :
SPC-107B
规格 :
200微升
价格 :
314.00美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 犬, 牛
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
StressMarq Biosciences 产品网页
文章摘录数: 1
参考文献
Ronzitti G, Bortolussi G, van Dijk R, Collaud F, Charles S, Leborgne C, et al. A translationally optimized AAV-UGT1A1 vector drives safe and long-lasting correction of Crigler-Najjar syndrome. Mol Ther Methods Clin Dev. 2016;3:16049 pubmed
产品信息
目录号 :
SPC-107B
产品名称 :
GRP78抗体
描述 :
兔抗大鼠GRP78多克隆
靶标 :
GRP78
共轭标签 :
未共轭
2021标价 :
314.00美元
Currency :
美元
研究领域(s) :
Cancer Heat Shock Cell Signaling Protein Trafficking Chaperone Proteins Tags and Cell Markers Organelle Markers
别称(s) :
78 kDa glucose regulated protein Antibody, 78 kDa glucose-regulated protein Antibody, AL022860 Antibody, AU019543 Antibody, BIP Antibody, D2Wsu141e Antibody, D2Wsu17e Antibody, Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 Antibody, Endoplasmic reticulum lumenal Antibody, Ca2+ binding protein grp78 Antibody, FLJ26106 Antibody, Glucose Regulated Protein 78kDa Antibody, GRP 78 Antibody, GRP-78 Antibody, GRP78_HUMAN Antibody, Heat shock 70 kDa protein 5 Antibody, Heat Shock 70kDa Protein 5 Antibody, HSCe70 Antibody, HSPA 5 Antibody, HSPA5 Antibody, Immunoglobulin Heavy Chain Binding Protein Antibody, Immunoglobulin heavy chain-binding protein Antibody, mBiP Antibody, MIF2 Antibody, Sez7 Antibody
规格 :
200微升
类别 :
抗体
产品类型 :
多克隆
免疫原 :
Rat GRP78 (Bip) synthetic peptide conjugated to KLH
免疫原物种 :
大鼠
登录号 :
NP_037215.1
Swiss Prot数据库 :
P06761
应用 :
免疫印迹免疫组化免疫细胞化学/IF免疫沉淀
宿主物种 :
兔
物种活性缩写 :
Hu Ms Rt Bv Fu Hm Mk Rb Xe Dg
物种活性全称 :
Human Mouse Rat Bovine Fungi Chestnut Blight (Cryphonectria parasitica) Hamster Monkey Rabbit African clawed frog (Xenopus laevis) Dog
抗体稀释 :
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
纯化 :
肽亲和纯化
储存缓冲液 :
PBS pH7.4, 50% 甘油, 0.09% 叠氮化钠
浓度 :
1毫克/毫升
特异性 :
Detects ~78kDa.
储存温度 :
-20ºC
运输温度 :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SPC-107B, RRID: AB_2119986
化验分析证明书 :
A 1:1000 dilution of SPC-107 was sufficient for detection of Grp78 in 10 µg of rat tissue lysate by ECL immunoblot analysis.
Cellular Localization :
Endoplasmic Reticulum Endoplasmic Reticulum Lumen Melanosome Cytoplasm
科研背景 :
GRP78 is a ubiquitously expressed, 78-kDa glucose regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1). GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3). In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer's patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7).
参考文献 :
1. Cho, S. et al. (2007). Mol Cell Biol 27(1): 368-83. 2. Yang, Y. et al. (1998) J Biol Chem 273: 25552-25555. 3. Luo, S. et al (2006) 26 (15): 5688-97. 4. Yu, Z. et al. (1999) Exp Neurol. 15: 302-314. 5. Koomagi, R. et al. (1999) Anticancer Res. 19:4333-4336. 6. Laquerre, S. et al. (1998) J. Virology 72: 4940-4949. 7. Dong, D. et al. (2005) Cancer Res 65(13): 5785-91.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SPC-107_GRP78_Antibody_WB_Human_Dog_Mouse_Cell-line-lysates_1.png SPC-107_GRP78_Antibody_ICC-IF_Human_Heat-Shocked-HeLa-Cells_100x_Composite.png SPC-107_GRP78_Antibody_ICC-IF_Human_Heat-Shocked-HeLa-Cells_20x_Composite.png SPC-107_GRP78_Antibody_WB_Rat_Tissue-lysates_1.png
SPC-107_GRP78_Antibody_IHC_Mouse_Hippoc
ampal-Section_20x_1.png
Image Alternative Text :
Rabbit Anti-GRP78 Antibody used in Immunohistochemistry (IHC) on Mouse Hippocampal Section (SPC-107) Rabbit Anti-GRP78 Antibody used in Western blot (WB) on Human, Dog, Mouse Cell line lysates (SPC-107) Rabbit Anti-GRP78 Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Heat Shocked Cervical cancer cell line (HeLa) (SPC-107) Rabbit Anti-GRP78 Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Heat Shocked Cervical cancer cell line (HeLa) (SPC-107) Rabbit Anti-GRP78 Antibody used in Western blot (WB) on Rat Tissue lysates (SPC-107)
更多信息或购买 :
StressMarq Biosciences 产品网页
公司信息
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
公司总部: 加拿大
StressMarq Biosciences Inc.是由Dr.Louwrier创建与温哥华的维多利亚，专注于热休克、细胞压力、离子通道及细胞信号研究领域，提供大量经过严格验证的抗体、蛋白及试剂盒。公司致力于提供高质量试剂以满足并超越客户期望。它也推出抗体试用项目，特别针对于新的研究领域，鼓励客户在购买之前先测试小规格试用产品。此外，公司提供采用新专利免疫组化技术的试剂盒，采用前所未有的抗体浓度进行实验。