产品简要
公司名称 :
StressMarq Biosciences
产品类型 :
抗体
产品名称 :
钙联接蛋白CT抗体
目录 :
SPC-108B
规格 :
200微升
价格 :
334.00美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 犬, 牛
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
StressMarq Biosciences 产品网页
文章摘录数: 7
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 1:200; 图 4
Jansen J, Cirak S, van Scherpenzeel M, Timal S, Reunert J, Rust S, et al. CCDC115 Deficiency Causes a Disorder of Golgi Homeostasis with Abnormal Protein Glycosylation. Am J Hum Genet. 2016;98:310-21 pubmed 出版商
Quintas A, Pérez Núñez D, Sánchez E, Nogal M, Hentze M, Castelló A, et al. Characterization of the African Swine Fever Virus Decapping Enzyme during Infection. J Virol. 2017;91: pubmed 出版商
Hernandez Tiedra S, Fabrias G, Davila D, Salanueva I, Casas J, Montes L, et al. Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy. 2016;12:2213-2229 pubmed
Martín Acebes M, Blázquez A, Cañas Arranz R, Vázquez Calvo Ã, Merino Ramos T, Escribano Romero E, et al. A recombinant DNA vaccine protects mice deficient in the alpha/beta interferon receptor against lethal challenge with Usutu virus. Vaccine. 2016;34:2066-73 pubmed 出版商
Gordo Gilart R, Andueza S, Hierro L, Jara P, Alvarez L. Functional Rescue of Trafficking-Impaired ABCB4 Mutants by Chemical Chaperones. PLoS ONE. 2016;11:e0150098 pubmed 出版商
Tulke S, Williams P, Hellysaz A, Ilegems E, Wendel M, Broberger C. Nucleobindin 1 (NUCB1) is a Golgi-resident marker of neurons. Neuroscience. 2016;314:179-88 pubmed 出版商
Gordo Gilart R, Hierro L, Andueza S, Muñoz Bartolo G, López C, Díaz C, et al. Heterozygous ABCB4 mutations in children with cholestatic liver disease. Liver Int. 2016;36:258-67 pubmed 出版商
产品信息
目录号 :
SPC-108B
产品名称 :
钙联接蛋白CT抗体
描述 :
兔抗狗钙联接蛋白CT多克隆
靶标 :
钙联接蛋白
共轭标签 :
未共轭
2021标价 :
334.00美元
Currency :
美元
研究领域(s) :
Cell Signaling Tags and Cell Markers Organelle Markers
别称(s) :
Calnexin antibody, CALX_HUMAN antibody, CANX antibody, CNX antibody, FLJ26570 antibody, Histocompatibility complex class I antigen binding protein p88 antibody, IP90 antibody, Major histocompatibility complex class I antigen-binding protein p88 antibody, P90 antibody
规格 :
200微升
类别 :
抗体
产品类型 :
多克隆
免疫原 :
Dog calnexin C-terminal synthetic peptide conjugated to KLH. Identical to human, mouse and rat calnexin sequences over these residues.
免疫原物种 :
狗
登录号 :
NP_001003232.1
Swiss Prot数据库 :
P24643
应用 :
免疫印迹免疫细胞化学/IF免疫组化
宿主物种 :
兔
物种活性缩写 :
Hu Ms Rt Bv Mk Ck Dg GP Hm Pg Qu Rb Sh Dr Xe
物种活性全称 :
Human Mouse Rat Bovine Monkey Chicken Dog Guinea Pig (Cavia porcellus) Hamster Pig Avian Quail Rabbit Sheep Fruit Fly (Drosophila melanogaster) African clawed frog (Xenopus laevis)
抗体稀释 :
WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
纯化 :
肽亲和纯化
储存缓冲液 :
PBS pH7.4, 50% 甘油, 0.09% 叠氮化钠
浓度 :
1毫克/毫升
特异性 :
Detects the C-terminal domain of Calnexin ~90kDa. Weak detection in Chicken, Drosophila, and Xenopus tissues
储存温度 :
-20ºC
运输温度 :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SPC-108B, RRID: AB_2069000
化验分析证明书 :
A 1:1000 dilution of SPC-108 was sufficient for detection of Calnexin in 10 µg of HeLa cell lysate by ECL immunoblot analysis.
Cellular Localization :
Endoplasmic Reticulum Endoplasmic Reticulum Lumen Melanosome Cytoplasm
科研背景 :
Calnexin, an abundant ~90kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 (1). It consists of a large 50kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail (2, 3). Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention (4), calnexin has positively charged cytosolic residues that do the same thing (3). Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multi-subunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their mono-glycosylated glycans (5, 6). Calnexin has also been shown to associate with the major histocompatibility complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin (7).
参考文献 :
1. Rajagopalan S., Xu Y., and Brenner M.B. (1994) Science 263(5145): 387-90. 2. Tjoelker L.W., et al. (1994) Biochemistry 33: 3229. 3. Schrag J. et al. (2001) Molecular Cell 8(3): 633-644. 4. Janiszewski M. (2005) J. Biol Chem. 280(49): 40813-40819. 5. Elagoz A., Callejo M., Armstrong J., and Rokeach L. A. (1999) J. Cell Sci. 112: 4449-4460. 6. Otteken A. and Moss B. (1996) J Bio Chem. 271(1): 97-103. 7. Galvin K. et al. (1992) Proc Natl Acad Sci USA. 89(18): 8452-6.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SPC-108_Calnexin_Antibody_WB_Rat_Tissue-lysates_1.png
SPC-108_Calnexin_Antibody_IHC_Mouse_bac
kskin_1.png
SPC-108_Calnexin_Antibody_ICC-IF_Human_HeLa-cells_1.png SPC-108_Calnexin_Antibody_WB_Human_HeLa-cell-lysates_2.png
Image Alternative Text :
Rabbit Anti-Calnexin Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Cervical cancer cell line (HeLa) (SPC-108) Rabbit Anti-Calnexin Antibody used in Western blot (WB) on Human Cervical cancer cell line (HeLa) lysate (SPC-108) Rabbit Anti-Calnexin Antibody used in Immunohistochemistry (IHC) on Mouse backskin (SPC-108) Rabbit Anti-Calnexin Antibody used in Western blot (WB) on Rat Tissue lysates (SPC-108)
更多信息或购买 :
StressMarq Biosciences 产品网页
公司信息
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
公司总部: 加拿大
StressMarq Biosciences Inc.是由Dr.Louwrier创建与温哥华的维多利亚，专注于热休克、细胞压力、离子通道及细胞信号研究领域，提供大量经过严格验证的抗体、蛋白及试剂盒。公司致力于提供高质量试剂以满足并超越客户期望。它也推出抗体试用项目，特别针对于新的研究领域，鼓励客户在购买之前先测试小规格试用产品。此外，公司提供采用新专利免疫组化技术的试剂盒，采用前所未有的抗体浓度进行实验。