产品简要
公司名称 :
StressMarq Biosciences
产品类型 :
抗体
产品名称 :
Toll样受体4抗体
目录 :
SPC-200D
规格 :
100微克
价格 :
268.00美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 流式细胞仪
更多信息或购买 :
StressMarq Biosciences 产品网页
文章摘录数: 2
参考文献
Yanagawa M, Uchida K, Ando Y, Tomiyama T, Yamaguchi T, Ikeura T, et al. Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis. J Gastroenterol. 2018;53:449-460 pubmed 出版商
Kuwabara Y, Katayama A, Kurihara S, Ito M, Yonezawa M, Ouchi N, et al. Diversity of progesterone action on lipopolysaccharide-induced expression changes in cultured human cervical fibroblasts according to inflammation and treatment timing. Am J Reprod Immunol. 2017;78: pubmed 出版商
产品信息
目录号 :
SPC-200D
产品名称 :
Toll样受体4抗体
描述 :
兔抗人类Toll样受体4多克隆
靶标 :
Toll样受体4
共轭标签 :
未共轭
2021标价 :
268.00美元
Currency :
美元
研究领域(s) :
Immunology Innate Immunity Macrophage Immunology Immunoglobulins Immunoglobulin Receptors Cardiovascular System Atherosclerosis Vascular Inflammation Inflammatory Mediators Immunology Adaptive Immunity Regulatory T Cells Immunology Innate Immunity TLR Signaling
别称(s) :
ARMD10抗体, CD284抗体, TLR 4抗体, TOLL抗体, Toll样受体4抗体
规格 :
100微克
类别 :
抗体
产品类型 :
多克隆
免疫原 :
Developed against a synthetic peptide corresponding to amino acids 420-435 of human TLR4
免疫原物种 :
人类
登录号 :
NP_612564.1
Swiss Prot数据库 :
O00206
应用 :
免疫印迹免疫组化免疫细胞化学/IF FCM流式细胞仪
宿主物种 :
兔
物种活性缩写 :
Hu Ms
物种活性全称 :
人类小鼠
抗体稀释 :
WB (1:500), IHC (1:50); optimal dilutions for assays should be determined by the user.
纯化 :
蛋白质A纯化
储存缓冲液 :
PBS, 50% 甘油, 0.09% 叠氮化钠
浓度 :
1毫克/毫升
特异性 :
Detects ~75-80kDa when tested against partial recombinant mouse TLR4 (extra-cellular portion plus His-tag).
储存温度 :
-20ºC
运输温度 :
Blue Ice or 4ºC
Cite this Product :
StressMarq Biosciences Cat# SPC-200D, RRID: AB_2204998
化验分析证明书 :
2 µg/ml of SPC-200 was sufficient for detection of TLR4 in 100 ng of partial recombinant mouse TLR4 protein by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Cellular Localization :
膜
科研背景 :
The Toll-like receptor (TLR) family in mammal comprises a family of trans-membrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and 1L-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylo-genetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Amount this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The mouse TLR4 cDNA codes for a protein consisting of 839 amino acids, with an approximate molecular weight of 90kDa (6).
参考文献 :
1. Muzio M., Natoli G., Saccan S., Levrero M., and Mantovani A. (1998) J. Exp. Med. 187: 2097-2101. 2. Medzhitov R. and Janeway C.A (1997) Cell. 91: 295-298. 3. Chuang T.H. and Ulevitch R.J. (2001) Biochim. Biophys. Acta. 1518(1-2): 157-161. 4. Takeuchi O., et al. (1999) Immunity. 11: 443. 5. Poltorak A., Riccardi-Castagnoli P., Citterio S., and Butler B. (2000) Proc. Natl. Acad. Sci USA. 97: 2163-2167. 6. Medzhitov R., Preston-Hurlburt P. and Janeway C.A. (1997) Jr. Nature. 388(6640): 394-397.
Field of Use :
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Image Filenames :
SPC-200_TLR4_Antibody_IHC_Mouse_colon-colitis_1.png SPC-200_TLR4_Antibody_WB_Human_Mouse_Cell-line-lysates_1.png SPC-200_TLR4_Antibody_FCM_Human_Monocytic-Leukemia-cells-THP-1_1.png SPC-200_TLR4_Antibody_IHC_Mouse_Spleen-tissue_1.png SPC-200_TLR4_Antibody_IHC_Mouse_spleen-tissue_2.png
Image Alternative Text :
Rabbit Anti-TLR4 Antibody used in Immunohistochemistry (IHC) on Mouse colon colitis (SPC-200) Rabbit Anti-TLR4 Antibody used in Western blot (WB) on Human, Mouse Cell line lysates (SPC-200) Rabbit Anti-TLR4 Antibody used in Flow Cytometry (FCM) on Human Monocytic Leukemia cells (THP-1) (SPC-200) Rabbit Anti-TLR4 Antibody used in Immunohistochemistry (IHC) on Mouse Spleen tissue (SPC-200) Rabbit Anti-TLR4 Antibody used in Immunohistochemistry (IHC) on Mouse spleen tissue (SPC-200)
更多信息或购买 :
StressMarq Biosciences 产品网页
公司信息
StressMarq Biosciences
PO Box 55036 CADBORO BAY
3825 Cadboro Bay Road
Victoria BC V8N 4G0
info@stressmarq.com
http://www.stressmarq.com
1-250-294-9065
公司总部: 加拿大
StressMarq Biosciences Inc.是由Dr.Louwrier创建与温哥华的维多利亚，专注于热休克、细胞压力、离子通道及细胞信号研究领域，提供大量经过严格验证的抗体、蛋白及试剂盒。公司致力于提供高质量试剂以满足并超越客户期望。它也推出抗体试用项目，特别针对于新的研究领域，鼓励客户在购买之前先测试小规格试用产品。此外，公司提供采用新专利免疫组化技术的试剂盒，采用前所未有的抗体浓度进行实验。