产品简要
公司名称 :
Synaptic Systems
产品类型 :
抗体
产品名称 :
Synaptotagmin 1
目录 :
105 011
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
41.1
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片
更多信息或购买 :
文章摘录数: 74
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 小鼠; 图 2f
  • 免疫印迹; 小鼠; 图 2d
Chen H, Zhang Brotzge X, Morozov Y, Li Y, Wang S, Zhang H, et al. Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. JCI Insight. 2021;6: pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 1j
Haytural H, Jordà Siquier T, Winblad B, Mulle C, Tjernberg L, Granholm A, et al. Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease. Brain Commun. 2021;3:fcab079 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 1b
Turecek J, Regehr W. Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5b
Sclip A, Sudhof T. LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses. elife. 2020;9: pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:200; 图 2d
Bouhours B, Gjoni E, Kochubey O, Schneggenburger R. Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons. J Neurosci. 2017;37:4604-4617 pubmed 出版商
  • 免疫印迹; 牛; 图 s1
Gümürdü A, Yildiz R, Eren E, Karakülah G, Unver T, Genc S, et al. MicroRNA exocytosis by large dense-core vesicle fusion. Sci Rep. 2017;7:45661 pubmed 出版商
  • 免疫印迹; 小鼠; 表 1
Cao M, Wu Y, Ashrafi G, McCartney A, Wheeler H, Bushong E, et al. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron. 2017;93:882-896.e5 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 2a
Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, et al. Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly. Neuron. 2017;93:854-866.e4 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 1a
Horvath P, Kavalali E, Monteggia L. CRISPR/Cas9 system-mediated impairment of synaptobrevin/VAMP function in postmitotic hippocampal neurons. J Neurosci Methods. 2017;278:57-64 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 5b
Wolfes A, Ahmed S, Awasthi A, Stahlberg M, Rajput A, Magruder D, et al. A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes. J Gen Physiol. 2017;149:149-170 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Bodaleo F, Montenegro Venegas C, Henríquez D, Court F, Gonzalez Billault C. Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology. Sci Rep. 2016;6:30069 pubmed 出版商
  • 免疫印迹; 大鼠; 图 6a
Villarroel Campos D, Henríquez D, Bodaleo F, Oguchi M, Bronfman F, Fukuda M, et al. Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B. J Neurosci. 2016;36:7298-313 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3a
Sclip A, Bacaj T, Giam L, Sudhof T. Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction. PLoS ONE. 2016;11:e0158295 pubmed 出版商
  • 免疫组化; 小鼠; 图 4a
  • 免疫印迹; 小鼠; 图 2b
Emanuele M, Esposito A, Camerini S, Antonucci F, Ferrara S, Seghezza S, et al. Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts. EBioMedicine. 2016;7:191-204 pubmed 出版商
  • 免疫印迹; 小鼠; 1:300; 图 5
Siegert S, Seo J, Kwon E, Rudenko A, Cho S, Wang W, et al. The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nat Neurosci. 2015;18:1008-16 pubmed 出版商
  • 免疫组化; 小鼠
Tyzack G, Sitnikov S, Barson D, Adams Carr K, Lau N, Kwok J, et al. Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression. Nat Commun. 2014;5:4294 pubmed 出版商
  • 免疫印迹; 大鼠
Wilhelm B, Mandad S, Truckenbrodt S, Kr hnert K, Sch fer C, Rammner B, et al. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science. 2014;344:1023-8 pubmed 出版商
  • 免疫印迹; 大鼠
Xu W, Tse Y, Dobie F, Baudry M, Craig A, Wong T, et al. Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression. J Neurosci. 2013;33:5867-5877 pubmed 出版商
  • 免疫印迹; 小鼠
Sharma M, Burr J, S dhof T. CSP? promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol. 2011;13:30-9 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Xue M, Craig T, Shin O, Li L, Brautigam C, Tomchick D, et al. Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. PLoS ONE. 2010;5: pubmed 出版商
Peixoto R, Chantranupong L, Hakim R, Levasseur J, Wang W, Merchant T, et al. Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B-/- Mice. Cell Rep. 2019;29:2016-2027.e4 pubmed 出版商
Kreutzberger A, Kiessling V, Stroupe C, Liang B, Preobraschenski J, Ganzella M, et al. In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties. Nat Commun. 2019;10:3904 pubmed 出版商
Zurawski Z, Thompson Gray A, Brady L, Page B, Church E, Harris N, et al. Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes. Sci Signal. 2019;12: pubmed 出版商
Turecek J, Regehr W. Neuronal Regulation of Fast Synaptotagmin Isoforms Controls the Relative Contributions of Synchronous and Asynchronous Release. Neuron. 2019;101:938-949.e4 pubmed 出版商
Hoffmann S, Orlando M, Andrzejak E, Bruns C, Trimbuch T, Rosenmund C, et al. Light-Activated ROS Production Induces Synaptic Autophagy. J Neurosci. 2019;39:2163-2183 pubmed 出版商
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, et al. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science. 2019;363: pubmed 出版商
Peggion C, Stella R, Chemello F, Massimino M, Arrigoni G, Cagnin S, et al. The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis. Mol Neurobiol. 2019;56:3420-3436 pubmed 出版商
Nazir F, Becker B, Brinkmalm A, Höglund K, Sandelius Å, Bergström P, et al. Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons. Neurochem Int. 2018;121:38-49 pubmed 出版商
Bello O, Jouannot O, Chaudhuri A, Stroeva E, Coleman J, Volynski K, et al. Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis. Proc Natl Acad Sci U S A. 2018;115:E7624-E7631 pubmed 出版商
Balietti M, Fattorini G, Pugliese A, Marcotulli D, Bragina L, Conti F. Two Behavioral Tests Allow a Better Correlation Between Cognitive Function and Expression of Synaptic Proteins. Front Aging Neurosci. 2018;10:91 pubmed 出版商
Fernström E, Minta K, Andreasson U, Sandelius A, Wasling P, Brinkmalm A, et al. Cerebrospinal fluid markers of extracellular matrix remodelling, synaptic plasticity and neuroinflammation before and after cranial radiotherapy. J Intern Med. 2018;: pubmed 出版商
Farsi Z, Gowrisankaran S, Krunic M, Rammner B, Woehler A, Lafer E, et al. Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity. elife. 2018;7: pubmed 出版商
Houy S, Groffen A, Ziomkiewicz I, Verhage M, Pinheiro P, Sørensen J. Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs. elife. 2017;6: pubmed 出版商
Caswell P, Dickens M. JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells. Mol Cell Biochem. 2018;444:1-13 pubmed 出版商
Lüningschrör P, Binotti B, Dombert B, Heimann P, Pérez Lara A, Slotta C, et al. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017;8:678 pubmed 出版商
Tomatis V, Josh P, Papadopulos A, Gormal R, Lanoue V, Martin S, et al. ENA/VASP proteins regulate exocytosis by mediating myosin VI-dependent recruitment of secretory granules to the cortical actin network. Mol Cell Neurosci. 2017;84:100-111 pubmed 出版商
Liu T, Li H, Hong W, Han W. Brefeldin A-inhibited guanine nucleotide exchange protein 3 is localized in lysosomes and regulates GABA signaling in hippocampal neurons. J Neurochem. 2016;139:748-756 pubmed 出版商
Acuna C, Liu X, Sudhof T. How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs. Neuron. 2016;91:792-807 pubmed 出版商
Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni R, et al. PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery. Cell Rep. 2016;15:117-131 pubmed 出版商
Koo S, Kochlamazashvili G, Rost B, Puchkov D, Gimber N, Lehmann M, et al. Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission. Neuron. 2015;88:330-44 pubmed 出版商
Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes D, Anane D, et al. Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1. Nat Commun. 2015;6:8302 pubmed 出版商
Liu Y, Li H, Sugiura Y, Han W, Gallardo G, Khvotchev M, et al. Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice. J Neurosci. 2015;35:11514-31 pubmed 出版商
Patzke C, Han Y, Covy J, Yi F, Maxeiner S, Wernig M, et al. Analysis of conditional heterozygous STXBP1 mutations in human neurons. J Clin Invest. 2015;125:3560-71 pubmed 出版商
Liu H, Bai H, Xue R, Takahashi H, Edwardson J, Chapman E. Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission. Nat Neurosci. 2014;17:670-7 pubmed 出版商
Lobsiger C, Boillée S, Pozniak C, Khan A, McAlonis Downes M, Lewcock J, et al. C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A. 2013;110:E4385-92 pubmed 出版商
Kaeser Woo Y, Younts T, Yang X, Zhou P, Wu D, Castillo P, et al. Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP. J Neurosci. 2013;33:9769-80 pubmed 出版商
Honigmann A, van den Bogaart G, Iraheta E, Risselada H, Milovanovic D, Mueller V, et al. Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. Nat Struct Mol Biol. 2013;20:679-86 pubmed 出版商
Ahmed S, Holt M, Riedel D, Jahn R. Small-scale isolation of synaptic vesicles from mammalian brain. Nat Protoc. 2013;8:998-1009 pubmed 出版商
Jovicic A, Roshan R, Moisoi N, Pradervand S, Moser R, Pillai B, et al. Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes. J Neurosci. 2013;33:5127-37 pubmed 出版商
Zhou P, Pang Z, Yang X, Zhang Y, Rosenmund C, Bacaj T, et al. Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion. EMBO J. 2013;32:159-71 pubmed 出版商
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T. Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission. Eur J Neurosci. 2012;36:3005-20 pubmed 出版商
Greif K, Asabere N, Lutz G, Gallo G. Synaptotagmin-1 promotes the formation of axonal filopodia and branches along the developing axons of forebrain neurons. Dev Neurobiol. 2013;73:27-44 pubmed 出版商
Bragina L, Fattorini G, Gioved S, Melone M, Bosco F, Benfenati F, et al. Analysis of Synaptotagmin, SV2, and Rab3 Expression in Cortical Glutamatergic and GABAergic Axon Terminals. Front Cell Neurosci. 2011;5:32 pubmed 出版商
Malarkey E, Parpura V. Temporal characteristics of vesicular fusion in astrocytes: examination of synaptobrevin 2-laden vesicles at single vesicle resolution. J Physiol. 2011;589:4271-300 pubmed 出版商
Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, et al. Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis. J Neurosci. 2011;31:4886-95 pubmed 出版商
Treppmann P, Brunk I, Afube T, Richter K, Ahnert Hilger G. Neurotoxic phospholipases directly affect synaptic vesicle function. J Neurochem. 2011;117:757-64 pubmed 出版商
Hoopmann P, Punge A, Barysch S, Westphal V, B ckers J, Opazo F, et al. Endosomal sorting of readily releasable synaptic vesicles. Proc Natl Acad Sci U S A. 2010;107:19055-60 pubmed 出版商
Beurg M, Michalski N, Safieddine S, Bouleau Y, Schneggenburger R, Chapman E, et al. Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells. J Neurosci. 2010;30:13281-90 pubmed 出版商
Xiao L, Han Y, Runne H, Murray H, Kochubey O, Luthi Carter R, et al. Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons. Mol Cell Neurosci. 2010;44:374-85 pubmed 出版商
Pang Z, Cao P, Xu W, Sudhof T. Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II. J Neurosci. 2010;30:4132-42 pubmed 出版商
Glyvuk N, Tsytsyura Y, Geumann C, D Hooge R, Hüve J, Kratzke M, et al. AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. EMBO J. 2010;29:1318-30 pubmed 出版商
Kosacka J, Gericke M, Nowicki M, Kacza J, Borlak J, Spanel Borowski K. Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures. Neuroscience. 2009;162:282-91 pubmed 出版商
Jockusch W, Speidel D, Sigler A, S rensen J, Varoqueaux F, Rhee J, et al. CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell. 2007;131:796-808 pubmed 出版商
Tabuchi K, Blundell J, Etherton M, Hammer R, Liu X, Powell C, et al. A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science. 2007;318:71-6 pubmed
Willig K, Rizzoli S, Westphal V, Jahn R, Hell S. STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis. Nature. 2006;440:935-9 pubmed 出版商
Yelamanchili S, Pendyala G, Brunk I, Darna M, Albrecht U, Ahnert Hilger G. Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2. J Biol Chem. 2006;281:15671-9 pubmed
Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W. Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis. J Neurochem. 2005;95:1732-45 pubmed
Bonanomi D, Menegon A, Miccio A, Ferrari G, Corradi A, Kao H, et al. Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synaptic vesicle dynamics in developing neurons. J Neurosci. 2005;25:7299-308 pubmed 出版商
Evans G, Morgan A. Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity. Eur J Neurosci. 2005;21:2671-80 pubmed 出版商
Lazzell D, Belizaire R, Thakur P, Sherry D, Janz R. SV2B regulates synaptotagmin 1 by direct interaction. J Biol Chem. 2004;279:52124-31 pubmed 出版商
Chieregatti E, Chicka M, Chapman E, Baldini G. SNAP-23 functions in docking/fusion of granules at low Ca2+. Mol Biol Cell. 2004;15:1918-30 pubmed
Ferguson S, Savchenko V, Apparsundaram S, Zwick M, Wright J, Heilman C, et al. Vesicular localization and activity-dependent trafficking of presynaptic choline transporters. J Neurosci. 2003;23:9697-709 pubmed
Hu K, Rickman C, Carroll J, Davletov B. A common mechanism for the regulation of vesicular SNAREs on phospholipid membranes. Biochem J. 2004;377:781-5 pubmed
Von Kriegstein K, Schmitz F, Link E, S dhof T. Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses. Eur J Neurosci. 1999;11:1335-48 pubmed
产品信息
Cat. Nr. :
105 011
抗原 :
Synaptotagmin 1
同义词 :
p65, 突触i, Syt1
宿主物种 :
小鼠
Tpye :
单克隆
形式 :
纯化IgG
细胞系 :
41.1
亚类 :
IgG2a
免疫原 :
Recombinant protein corresponding to AA 80 to 421 from rat Synaptotagmin1 (UniProt Id: P21707)
反应物种 :
人类, 大鼠, 小鼠, 哺乳动物, 斑马鱼
免疫印迹 :
免疫印迹
免疫沉淀 :
免疫沉淀
免疫细胞化学 :
免疫细胞化学
免疫组化 :
免疫组化
免疫组化P :
免疫组化-P
EM :
EM
酶联免疫吸附测定 :
酶联免疫吸附测定
KO :
yes
规格 :
100微克
更多信息或购买 :
公司信息
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
公司总部: 德国