产品简要
公司名称 :
Synaptic Systems
产品类型 :
抗体
产品名称 :
Gephyrin
目录 :
147 111
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
3B11
反应物种 :
人类, 小鼠, 大鼠, 斑马鱼
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
文章摘录数: 63
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 2e
Han W, Li J, Pelkey K, Pandey S, Chen X, Wang Y, et al. Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions. Science. 2019;366:246-250 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3g
Chmielewska J, Kuzniewska B, Milek J, Urbanska K, Dziembowska M. Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage. Mol Neurobiol. 2019;56:2741-2759 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 4b
Pellegrini L, Hauser D, Li Y, Mamais A, Beilina A, Kumaran R, et al. Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice. Hum Mol Genet. 2018;27:3257-3271 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 4e
  • 免疫印迹; 小鼠; 1:50; 图 4a
Kumar A, Dejanovic B, Hetsch F, Semtner M, Fusca D, Arjune S, et al. S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency. J Clin Invest. 2017;127:4365-4378 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000; 图 s2e
  • 免疫印迹; 小鼠; 1:10,000; 图 4c
Tanabe Y, Naito Y, Vasuta C, Lee A, Soumounou Y, Linhoff M, et al. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2?. Nat Commun. 2017;8:408 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3a
Daniel J, Cooper B, Palvimo J, Zhang F, Brose N, Tirard M. Analysis of SUMO1-conjugation at synapses. elife. 2017;6: pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 3-s1a
Ripamonti S, Ambrozkiewicz M, Guzzi F, Gravati M, Biella G, Bormuth I, et al. Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons. elife. 2017;6: pubmed 出版商
  • 免疫印迹; 小鼠; 图 s4b
Li J, Casteels T, Frogne T, Ingvorsen C, Honore C, Courtney M, et al. Artemisinins Target GABAA Receptor Signaling and Impair ? Cell Identity. Cell. 2017;168:86-100.e15 pubmed 出版商
  • 免疫组化; 大鼠; 图 s2
Ghosh H, Auguadri L, Battaglia S, Simone Thirouin Z, Zemoura K, Messner S, et al. Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission. Nat Commun. 2016;7:13365 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 1d
  • 免疫组化; 斑马鱼; 1:250; 图 4b
Gross G, Straub C, Perez Sanchez J, Dempsey W, Junge J, Roberts R, et al. An E3-ligase-based method for ablating inhibitory synapses. Nat Methods. 2016;13:673-8 pubmed 出版商
  • 免疫组化; 大鼠; 图 5e
  • 免疫印迹; 大鼠; 图 2b
Um J, Choii G, Park D, Kim D, Jeon S, Kang H, et al. IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation. J Biol Chem. 2016;291:10119-30 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6a
Valenza M, Chen J, Di Paolo E, Ruozi B, Belletti D, Ferrari Bardile C, et al. Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice. EMBO Mol Med. 2015;7:1547-64 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 7
Bender J, Engeholm M, Ederer M, Breu J, Møller T, Michalakis S, et al. Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. PLoS ONE. 2015;10:e0136768 pubmed 出版商
  • 免疫印迹; 小鼠; 1:3000
Chugh D, Ali I, Bakochi A, Bahonjic E, Etholm L, Ekdahl C. Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2. PLoS ONE. 2015;10:e0132366 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Antonelli R, Pizzarelli R, Pedroni A, Fritschy J, Del Sal G, Cherubini E, et al. Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction. Nat Commun. 2014;5:5066 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000; 图 e4
Karayannis T, Au E, Patel J, Kruglikov I, Markx S, Delorme R, et al. Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission. Nature. 2014;511:236-40 pubmed
Kim H, Yang Y, Hwang H, Lee H, Jang H, Kim J, et al. Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice. Sci Rep. 2019;9:17761 pubmed 出版商
Bessières B, Jia M, Travaglia A, Alberini C. Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat basolateral amygdala. Learn Mem. 2019;26:436-448 pubmed 出版商
Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, et al. SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring. Neuron. 2019;: pubmed 出版商
Terreros Roncal J, Flor García M, Moreno Jiménez E, Pallas Bazarra N, Rabano A, Sah N, et al. Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia. J Neurosci. 2019;: pubmed 出版商
Rhee H, Shaib A, Rehbach K, Lee C, Seif P, Thomas C, et al. An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons. Cell Rep. 2019;27:2212-2228.e7 pubmed 出版商
Petrov A, Lam M, Mast N, Moon J, Li Y, Maxfield E, et al. CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice. Neurotherapeutics. 2019;: pubmed 出版商
Dejanovic B, Huntley M, De Mazière A, Meilandt W, Wu T, Srinivasan K, et al. Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies. Neuron. 2018;100:1322-1336.e7 pubmed 出版商
Letellier M, Szíber Z, Chamma I, Saphy C, Papasideri I, Tessier B, et al. A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation. Nat Commun. 2018;9:3979 pubmed 出版商
Jia M, Travaglia A, Pollonini G, Fedele G, Alberini C. Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat medial prefrontal cortex. Learn Mem. 2018;25:533-543 pubmed 出版商
Trobiani L, Favaloro F, Di Castro M, Di Mattia M, Cariello M, Miranda E, et al. UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism. Neurobiol Dis. 2018;120:139-150 pubmed 出版商
Lee S, Shin S, Zhong P, Kim H, Kim D, Kim J, et al. Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes. Nat Commun. 2018;9:3434 pubmed 出版商
Früh S, Tyagarajan S, Campbell B, Bosshard G, Fritschy J. The catalytic function of the gephyrin-binding protein IQSEC3 regulates neurotransmitter-specific matching of pre- and post-synaptic structures in primary hippocampal cultures. J Neurochem. 2018;147:477-494 pubmed 出版商
Koga K, Shimoyama S, Yamada A, Furukawa T, Nikaido Y, Furue H, et al. Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex. Mol Pain. 2018;14:1744806918783478 pubmed 出版商
Li Y, Kim R, Cho Y, Song W, Kim D, Kim K, et al. Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and Inhibitory Synapse Development and Abnormal Social Communication and Startle Response. J Neurosci. 2018;38:5872-5887 pubmed 出版商
Mukherjee J, Cardarelli R, Cantaut Belarif Y, Deeb T, Srivastava D, Tyagarajan S, et al. Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses. Proc Natl Acad Sci U S A. 2017;114:11763-11768 pubmed 出版商
de Groot C, Floriou Servou A, Tsai Y, Früh S, Kohler M, Parkin G, et al. RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of ?2 GABAA receptors. PLoS Genet. 2017;13:e1007073 pubmed 出版商
Smith K, Jones K, Kopeikina K, Burette A, Copits B, Yoon S, et al. Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins. J Neurosci. 2017;37:11127-11139 pubmed 出版商
Hoon M, Krishnamoorthy V, Gollisch T, Falkenburger B, Varoqueaux F. Loss of Neuroligin3 specifically downregulates retinal GABAA?2 receptors without abolishing direction selectivity. PLoS ONE. 2017;12:e0181011 pubmed 出版商
Acuna C, Liu X, Sudhof T. How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs. Neuron. 2016;91:792-807 pubmed 出版商
Walker K, Modgil A, Albrecht D, Lomoio S, Haydon P, Moss S, et al. Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission. PLoS ONE. 2016;11:e0155799 pubmed 出版商
Ren Z, Pribiag H, Jefferson S, Shorey M, Fuchs T, Stellwagen D, et al. Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment. Biol Psychiatry. 2016;80:457-468 pubmed 出版商
Nakamura Y, Morrow D, Modgil A, Huyghe D, Deeb T, Lumb M, et al. Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged ?-Aminobutyric Acid Receptor, Type A (GABAA), ?2 Subunit Knock-in Mouse. J Biol Chem. 2016;291:12394-407 pubmed 出版商
O Sullivan G, Jedlicka P, Chen H, Kalbouneh H, Ippolito A, Deller T, et al. Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice. Mol Cell Neurosci. 2016;72:101-13 pubmed 出版商
Lenz M, Galanis C, Müller Dahlhaus F, Opitz A, Wierenga C, Szabó G, et al. Repetitive magnetic stimulation induces plasticity of inhibitory synapses. Nat Commun. 2016;7:10020 pubmed 出版商
Dejanovic B, Djémié T, Grünewald N, Suls A, Kress V, Hetsch F, et al. Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy. EMBO Mol Med. 2015;7:1580-94 pubmed 出版商
Jedlicka P, Vnencak M, Krueger D, Jungenitz T, Brose N, Schwarzacher S. Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo. Brain Struct Funct. 2015;220:47-58 pubmed
Papadopoulos T, Schemm R, Grubmüller H, Brose N. Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability. J Biol Chem. 2015;290:8256-70 pubmed 出版商
Brady M, Jacob T. Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation. Dev Neurobiol. 2015;75:1241-51 pubmed 出版商
Flores C, Nikonenko I, Mendez P, Fritschy J, Tyagarajan S, Muller D. Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation. Proc Natl Acad Sci U S A. 2015;112:E65-72 pubmed 出版商
La Fata G, Gärtner A, Domínguez Iturza N, Dresselaers T, Dawitz J, Poorthuis R, et al. FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry. Nat Neurosci. 2014;17:1693-700 pubmed 出版商
Dejanovic B, Schwarz G. Neuronal nitric oxide synthase-dependent S-nitrosylation of gephyrin regulates gephyrin clustering at GABAergic synapses. J Neurosci. 2014;34:7763-8 pubmed 出版商
Petrini E, Ravasenga T, Hausrat T, Iurilli G, Olcese U, Racine V, et al. Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP. Nat Commun. 2014;5:3921 pubmed 出版商
Han K, Holder J, Schaaf C, Lu H, Chen H, Kang H, et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013;503:72-7 pubmed 出版商
Hoy J, Haeger P, Constable J, Arias R, McCallum R, Kyweriga M, et al. Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions. J Neurosci. 2013;33:9364-84 pubmed 出版商
Schubert T, Hoon M, Euler T, Lukasiewicz P, Wong R. Developmental regulation and activity-dependent maintenance of GABAergic presynaptic inhibition onto rod bipolar cell axonal terminals. Neuron. 2013;78:124-37 pubmed 出版商
Tyagarajan S, Ghosh H, Yevenes G, Imanishi S, Zeilhofer H, Gerrits B, et al. Extracellular signal-regulated kinase and glycogen synthase kinase 3? regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. J Biol Chem. 2013;288:9634-47 pubmed 出版商
Nair R, Lauks J, Jung S, Cooke N, de Wit H, Brose N, et al. Neurobeachin regulates neurotransmitter receptor trafficking to synapses. J Cell Biol. 2013;200:61-80 pubmed 出版商
Su J, Stenbjorn R, Gorse K, Su K, Hauser K, Ricard Blum S, et al. Target-derived matricryptins organize cerebellar synapse formation through ?3?1 integrins. Cell Rep. 2012;2:223-30 pubmed 出版商
Murk K, Wittenmayer N, Michaelsen Preusse K, Dresbach T, Schoenenberger C, Korte M, et al. Neuronal profilin isoforms are addressed by different signalling pathways. PLoS ONE. 2012;7:e34167 pubmed 出版商
Varley Z, Pizzarelli R, Antonelli R, Stancheva S, Kneussel M, Cherubini E, et al. Gephyrin regulates GABAergic and glutamatergic synaptic transmission in hippocampal cell cultures. J Biol Chem. 2011;286:20942-51 pubmed 出版商
Hoon M, Soykan T, Falkenburger B, Hammer M, Patrizi A, Schmidt K, et al. Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina. Proc Natl Acad Sci U S A. 2011;108:3053-8 pubmed 出版商
Förstera B, Belaidi A, Jüttner R, Bernert C, Tsokos M, Lehmann T, et al. Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy. Brain. 2010;133:3778-94 pubmed 出版商
Ogino K, Ramsden S, Keib N, Schwarz G, Harvey R, Hirata H. Duplicated gephyrin genes showing distinct tissue distribution and alternative splicing patterns mediate molybdenum cofactor biosynthesis, glycine receptor clustering, and escape behavior in zebrafish. J Biol Chem. 2011;286:806-17 pubmed 出版商
Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton M, Südhof T. Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science. 2010;329:1663-7 pubmed 出版商
Waldvogel H, Baer K, Eady E, Allen K, Gilbert R, Mohler H, et al. Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study. J Comp Neurol. 2010;518:305-28 pubmed 出版商
Baer K, Waldvogel H, Faull R, Rees M. Localization of glycine receptors in the human forebrain, brainstem, and cervical spinal cord: an immunohistochemical review. Front Mol Neurosci. 2009;2:25 pubmed 出版商
Smolinsky B, Eichler S, Buchmeier S, Meier J, Schwarz G. Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis. J Biol Chem. 2008;283:17370-9 pubmed 出版商
产品信息
Cat. Nr. :
147 111
抗原 :
Gephyrin
同义词 :
Gphn
宿主物种 :
小鼠
Tpye :
单克隆
形式 :
纯化IgG
细胞系 :
3B11
亚类 :
IgG1
免疫原 :
Recombinant protein corresponding to AA 307 to 735 from rat Gephyrin (UniProt Id: Q03555)
反应物种 :
人类, 大鼠, 小鼠, 斑马鱼
免疫印迹 :
免疫印迹
免疫沉淀 :
免疫沉淀
免疫细胞化学 :
免疫细胞化学
免疫组化 :
免疫组化
酶联免疫吸附测定 :
酶联免疫吸附测定
KO :
yes
规格 :
100微克
更多信息或购买 :
公司信息
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
公司总部: 德国