产品简要
公司名称 :
Synaptic Systems
产品类型 :
抗体
产品名称 :
Abeta-pE3
目录 :
218 011
规格 :
100微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Feb 48
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 20
参考文献
Nie R, Wu Z, Ni J, Zeng F, Yu W, Zhang Y, et al. Porphyromonas gingivalis Infection Induces Amyloid-β Accumulation in Monocytes/Macrophages. J Alzheimers Dis. 2019;72:479-494 pubmed 出版商
Wang X, Wang L, Yu X, Li Y, Liu Z, Zou Y, et al. Glutaminyl cyclase inhibitor exhibits anti-inflammatory effects in both AD and LPS-induced inflammatory model mice. Int Immunopharmacol. 2019;75:105770 pubmed 出版商
Murray C, Gami Patel P, Gkanatsiou E, Brinkmalm G, Portelius E, Wirths O, et al. The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease. Acta Neuropathol Commun. 2018;6:62 pubmed 出版商
Schmidt F, Boltze J, Jäger C, Hofmann S, Willems N, Seeger J, et al. Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines. J Neuropathol Exp Neurol. 2015;74:912-23 pubmed 出版商
Hartlage Rübsamen M, Waniek A, Meissner J, Morawski M, Schilling S, Jäger C, et al. Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease. Acta Neuropathol. 2015;129:565-83 pubmed 出版商
Waniek A, Hartlage Rübsamen M, Höfling C, Kehlen A, Schilling S, Demuth H, et al. Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes. Biochim Biophys Acta. 2015;1852:146-55 pubmed 出版商
Sieczkowski E, Milenkovic I, Venkataramani V, Giera R, Ströbel T, Höftberger R, et al. I716F AβPP mutation associates with the deposition of oligomeric pyroglutamate amyloid-β and α-synucleinopathy with Lewy bodies. J Alzheimers Dis. 2015;44:103-14 pubmed 出版商
Bayer T, Wirths O. Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease. Acta Neuropathol. 2014;127:787-801 pubmed 出版商
Kalimo H, Lalowski M, Bogdanovic N, Philipson O, Bird T, Nochlin D, et al. The Arctic A?PP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated A?. Acta Neuropathol Commun. 2013;1:60 pubmed 出版商
Morawski M, Schilling S, Kreuzberger M, Waniek A, Jäger C, Koch B, et al. Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-? load and cognitive decline in Alzheimer's disease. J Alzheimers Dis. 2014;39:385-400 pubmed 出版商
Becker A, Kohlmann S, Alexandru A, Jagla W, Canneva F, B uscher C, et al. Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration. BMC Neurosci. 2013;14:108 pubmed 出版商
Wirths O, Hillmann A, Pradier L, Hartig W, Bayer T. Oligomeric pyroglutamate amyloid-? is present in microglia and a subfraction of vessels in patients with Alzheimer's disease: implications for immunotherapy. J Alzheimers Dis. 2013;35:741-9 pubmed 出版商
Wittnam J, Portelius E, Zetterberg H, Gustavsson M, Schilling S, Koch B, et al. Pyroglutamate amyloid ? (A?) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease. J Biol Chem. 2012;287:8154-62 pubmed 出版商
Morawski M, Brückner G, Jäger C, Seeger G, Matthews R, Arendt T. Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology. Brain Pathol. 2012;22:547-61 pubmed 出版商
Hartlage Rübsamen M, Morawski M, Waniek A, Jäger C, Zeitschel U, Koch B, et al. Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-A? deposits in hippocampus via distinct cellular mechanisms. Acta Neuropathol. 2011;121:705-19 pubmed 出版商
Jawhar S, Trawicka A, Jenneckens C, Bayer T, Wirths O. Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal A? aggregation in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Aging. 2012;33:196.e29-40 pubmed 出版商
Morawski M, Hartlage Rübsamen M, Jäger C, Waniek A, Schilling S, Schwab C, et al. Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. Acta Neuropathol. 2010;120:195-207 pubmed 出版商
Hartig W, Goldhammer S, Bauer U, Wegner F, Wirths O, Bayer T, et al. Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice. J Chem Neuroanat. 2010;40:82-92 pubmed 出版商
Wirths O, Bethge T, Marcello A, Harmeier A, Jawhar S, Lucassen P, et al. Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases. J Neural Transm (Vienna). 2010;117:85-96 pubmed 出版商
Wirths O, Breyhan H, Cynis H, Schilling S, Demuth H, Bayer T. Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model. Acta Neuropathol. 2009;118:487-96 pubmed 出版商
产品信息
Cat. Nr. :
218 011
抗原 :
Abeta-pE3
同义词 :
pE3-Abeta, Abeta(3(pE)-40/42), pGlu-Abeta, Abeta(3(pE)-40/42) pyro-Glu-Abeta, pyro-Glu-Abeta
宿主物种 :
小鼠
Tpye :
单克隆
形式 :
纯化IgG
细胞系 :
Feb 48
亚类 :
IgG1
免疫原 :
Synthetic peptide corresponding to AA 3 to 7 from human Abeta-pE3 (UniProt Id: P05067)
反应物种 :
human, rat, mouse, monkey
免疫印迹 :
免疫印迹
免疫组化 :
免疫组化
免疫组化P :
免疫组化-P
酶联免疫吸附测定 :
酶联免疫吸附测定
规格 :
100微克
更多信息或购买 :
公司信息
Synaptic Systems
Rudolf-Wissell-Str. 28
37079 Goettingen
lab@sysy.com
http://www.sysy.com
49-551-50556-0
公司总部: 德国