产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
老化490
目录 :
0414/10
规格 :
10 mg (also 50 mg)
价格 :
155美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 14
参考文献
Azad A, Yin Lim S, D Costa Z, Jones K, Diana A, Sansom O, et al. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO Mol Med. 2017;9:167-180 pubmed 出版商
Rogers S, Gahring L. Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways. PLoS ONE. 2015;10:e0143319 pubmed 出版商
Zhao L, Li J, Liao K, Luo N, Shi Q, Feng Z, et al. Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells. Int J Mol Sci. 2015;16:27411-21 pubmed 出版商
Jiang W, Ye L, Ruge F, Owen S, Martin T, Sun P, et al. YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells. J Transl Med. 2015;13:280 pubmed 出版商
Tactacan C, Phua Y, Liu L, Zhang L, Humphrey E, Cowley M, et al. The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling. Mol Cancer. 2015;14:139 pubmed 出版商
Shenoy A, Danial M, Blelloch R. Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis. EMBO J. 2015;34:1180-94 pubmed 出版商
Kubota H, Nagao S, Obata K, Hirono M. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS ONE. 2014;9:e106316 pubmed 出版商
Park S, Shin E, Min S, An J, Li Z, Hee Chung Y, et al. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology. 2013;38:1426-37 pubmed 出版商
Doulatov S, Notta F, Rice K, Howell L, Zelent A, Licht J, et al. PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes Dev. 2009;23:2076-87 pubmed 出版商
Fontaine R, Cases O, Lelievre V, Mesples B, Renauld J, Loron G, et al. IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis. Cell Death Differ. 2008;15:1542-52 pubmed 出版商
Lu Y, Zhou J, Xu C, Lin H, Xiao J, Wang Z, et al. JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes. Cell Physiol Biochem. 2008;21:305-14 pubmed 出版商
Jung S, Yang W, Kim J, Kim H, Kim E, Yun H, et al. Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis. 2008;29:713-21 pubmed 出版商
Gross E, Hsu A, Gross G. The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Am J Physiol Heart Circ Physiol. 2006;291:H827-34 pubmed
Bellik L, Vinci M, Filippi S, Ledda F, Parenti A. Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia. Br J Pharmacol. 2005;146:568-75 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
0414
SKU号 :
0414/10
产品名称 :
老化490
描述 :
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
靶标 :
EGF Receptor Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
294.31
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 u M for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo .
extended description :
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
化学品名文本 :
(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide
配方 :
C 17 H 14 N 2 O 3
配方文本 :
C17H14N2O3
cas num :
133550-30-8
美元 :
155美元
产品细节 :
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
别名 :
一类酪氨酸激酶抑制剂老化490
储存 :
存放在RT
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国