产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
GF 109203X
目录 :
0741/1
规格 :
1 mg (also 10 mg)
价格 :
120美元
更多信息或购买 :
文章摘录数: 45
参考文献
Wijerathne T, Kim J, Kim M, Kim C, Chae M, Lee S, et al. Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner. Korean J Physiol Pharmacol. 2019;23:381-392 pubmed 出版商
Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed 出版商
O Neill N, Sylantyev S. Feature Article: Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C. Exp Biol Med (Maywood). 2018;243:1046-1055 pubmed 出版商
Zhong W, Chebolu S, Darmani N. Intracellular emetic signaling evoked by the L-type Ca2+ channel agonist FPL64176 in the least shrew (Cryptotis parva). Eur J Pharmacol. 2018;834:157-168 pubmed 出版商
Fish J, Cantu Gutierrez M, Dang L, Khyzha N, Chen Z, Veitch S, et al. Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development. 2017;144:2428-2444 pubmed 出版商
Jantarajit W, Lertsuwan K, Teerapornpuntakit J, Krishnamra N, Charoenphandhu N. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels. Am J Physiol Cell Physiol. 2017;313:C118-C129 pubmed 出版商
Al Bayati A, Lukka D, Brown A, Walker M. Effects of thrombin on insulin signalling and glucose uptake in cultured human myotubes. J Diabetes Complications. 2016;30:1209-16 pubmed 出版商
Qu M, Ji W, Zhao T, Fang C, Mao S, Gao Z. Neurophysiological mechanisms of bradykinin-evoked mucosal chloride secretion in guinea pig small intestine. World J Gastrointest Pathophysiol. 2016;7:150-9 pubmed 出版商
Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, et al. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB J. 2016;30:1534-47 pubmed 出版商
Seifert L, Deutsch M, Alothman S, Alqunaibit D, Werba G, Pansari M, et al. Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways. Cell Rep. 2015;13:1909-1921 pubmed 出版商
Davis W. The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Curr Alzheimer Res. 2015;12:847-59 pubmed
Yuan X, Chen H, Li X, Dai M, Zeng H, Shan L, et al. Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo. Sci Rep. 2015;5:12889 pubmed 出版商
Chen Y, Kan W. Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells. Biochim Biophys Acta. 2015;1853:2662-75 pubmed 出版商
Devinney M, Fields D, Huxtable A, Peterson T, Dale E, Mitchell G. Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons. J Neurosci. 2015;35:8107-17 pubmed 出版商
Lin T, Lu C, Wu C, Huang S, Wang S. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. Int J Mol Sci. 2015;16:5555-71 pubmed 出版商
Rattan S, Ali M. Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2015;308:G605-12 pubmed 出版商
Yu Y, Zhang M, Zhang X, Cai Q, Zhu Z, Jiang W, et al. Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. J Exp Clin Cancer Res. 2014;33:85 pubmed 出版商
Wouters E, Hudson C, McArdle C, Bernal A. Central role for protein kinase C in oxytocin and epidermal growth factor stimulated cyclooxygenase 2 expression in human myometrial cells. BMC Res Notes. 2014;7:357 pubmed 出版商
Guemez Gamboa A, Xu L, Meng D, Spitzer N. Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching. Neuron. 2014;82:1004-16 pubmed 出版商
Zhao L, Levine E. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 2014;111:1008-15 pubmed 出版商
Mitrugno A, Williams D, Kerrigan S, Moran N. A novel and essential role for Fc?RIIa in cancer cell-induced platelet activation. Blood. 2014;123:249-60 pubmed 出版商
Jahchan N, Dudley J, Mazur P, Flores N, Yang D, Palmerton A, et al. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov. 2013;3:1364-77 pubmed 出版商
Copits B, Swanson G. Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis. J Biol Chem. 2013;288:8952-65 pubmed 出版商
Oh W, Hill T, Zito K. Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening. Proc Natl Acad Sci U S A. 2013;110:E305-12 pubmed 出版商
Gao H, Miyata K, Bhaskaran M, Derbenev A, Zsombok A. Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse. Diabetes. 2012;61:1381-90 pubmed 出版商
Khuituan P, Teerapornpuntakit J, Wongdee K, Suntornsaratoon P, Konthapakdee N, Sangsaksri J, et al. Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D?-enhanced duodenal calcium transport in male mice. Am J Physiol Endocrinol Metab. 2012;302:E903-13 pubmed 出版商
Meotti F, Campos R, da Silva K, Paszcuk A, Costa R, Calixto J. Inflammatory muscle pain is dependent on the activation of kinin B? and B? receptors and intracellular kinase pathways. Br J Pharmacol. 2012;166:1127-39 pubmed 出版商
Hudson C, Heesom K, Lopez Bernal A. Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1). Mol Hum Reprod. 2012;18:265-79 pubmed 出版商
Zsombok A, Bhaskaran M, Gao H, Derbenev A, Smith B. Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice. J Neurosci. 2011;31:14024-31 pubmed 出版商
Ajiro Y, Saegusa N, Giles W, Stafforini D, Spitzer K. Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. Am J Physiol Heart Circ Physiol. 2011;301:H2395-401 pubmed 出版商
Poteser M, Schleifer H, Lichtenegger M, Schernthaner M, Stockner T, Kappe C, et al. PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes. Proc Natl Acad Sci U S A. 2011;108:10556-61 pubmed 出版商
Barbaric I, Jones M, Harley D, Gokhale P, Andrews P. High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival. J Biomol Screen. 2011;16:603-17 pubmed 出版商
Lau C, Lytle C, Straus D, DeFea K. Apical and basolateral pools of proteinase-activated receptor-2 direct distinct signaling events in the intestinal epithelium. Am J Physiol Cell Physiol. 2011;300:C113-23 pubmed 出版商
Riedl M, Braun P, Kitto K, ROIKO S, Anderson L, Honda C, et al. Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. J Neurosci. 2009;29:13377-88 pubmed 出版商
Freitas M, Eto M, Kirkbride J, Schott C, Sassard J, Stoclet J. Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle. Fundam Clin Pharmacol. 2009;23:169-78 pubmed 出版商
Kim S, Danilenko M, Kim T. Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds. Br J Pharmacol. 2008;155:814-25 pubmed 出版商
Brager D, Johnston D. Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons. J Neurosci. 2007;27:13926-37 pubmed
Zapata A, Kivell B, Han Y, Javitch J, Bolan E, Kuraguntla D, et al. Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. J Biol Chem. 2007;282:35842-54 pubmed
Chung H, Seo S, Moon M, Park S. IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4. J Endocrinol. 2007;194:77-85 pubmed
Cobine C, Callaghan B, Keef K. Role of L-type calcium channels and PKC in active tone development in rabbit coronary artery. Am J Physiol Heart Circ Physiol. 2007;292:H3079-88 pubmed
O Riordan K, Huang I, Pizzi M, Spano P, Boroni F, Egli R, et al. Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors. J Neurosci. 2006;26:4870-9 pubmed
Jackson E, Gao L, Zhu C. Mechanism of the vascular angiotensin II/alpha2-adrenoceptor interaction. J Pharmacol Exp Ther. 2005;314:1109-16 pubmed
Corsini E, Viviani B, Zancanella O, Lucchi L, Visioli F, Serrero G, et al. Induction of adipose differentiation related protein and neutral lipid droplet accumulation in keratinocytes by skin irritants. J Invest Dermatol. 2003;121:337-44 pubmed
Wibberley A, Chen Z, Hu E, Hieble J, Westfall T. Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle. Br J Pharmacol. 2003;138:757-66 pubmed
Sano S, Kira M, Takagi S, Yoshikawa K, Takeda J, Itami S. Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2000;97:13824-9 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
0741
SKU号 :
0741/1
产品名称 :
GF 109203X
描述 :
Protein kinase C inhibitor
靶标 :
Protein Kinase C Inhibitors
类别 :
Small Molecules
单位尺寸 :
1 mg (also 10 mg)
纯度 :
98%
观察到的分子量 :
412.49
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
GF 109203X is a very potent and selective inhibitor of protein kinase C, selective for the and 1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 u M for , 1, , and isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 u M respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Anti-inflammatory in vivo .
extended description :
Protein kinase C inhibitor
化学品名文本 :
2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide
配方 :
C 25 H 24 N 4 O 2
配方文本 :
C25H24N4O2
cas num :
133052-90-1
美元 :
120美元
产品细节 :
Protein kinase C inhibitor
别名 :
G 6850, Bisindolylmaleimide I
储存 :
存放在RT
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国