产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
NS 398
目录 :
0942/10
规格 :
10 mg (also 50 mg)
价格 :
238美元
更多信息或购买 :
文章摘录数: 14
参考文献
Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis. 2019;25:329-344 pubmed
Bonfill Teixidor E, Otxoa de Amezaga A, Font Nieves M, Sans Fons M, Planas A. Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide. J Neuroinflammation. 2017;14:3 pubmed 出版商
Tunaru S, Chennupati R, Nusing R, Offermanns S. Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor. PLoS ONE. 2016;11:e0163633 pubmed 出版商
Ho Y, Lin Y, Wu C, Chao Y, Chang A, Chan J. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. J Biomed Sci. 2015;22:46 pubmed 出版商
Wei S, Yu Y, Zhang Z, Felder R. Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat. Hypertension. 2015;65:1126-33 pubmed 出版商
Liu L, Liu J, Tian X, Wong W, Lau C, Xu A, et al. Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress. Antioxid Redox Signal. 2014;21:1571-81 pubmed 出版商
Sugiyama T, Meakin L, Galea G, Lanyon L, Price J. The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice. Osteoporos Int. 2013;24:383-8 pubmed 出版商
Font Nieves M, Sans Fons M, Gorina R, Bonfill Teixidor E, Salas Perdomo A, Márquez Kisinousky L, et al. Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes. J Biol Chem. 2012;287:6454-68 pubmed 出版商
Chia E, Kagota S, Wijekoon E, McGuire J. Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol. 2011;11:10 pubmed 出版商
Buenestado A, Grassin Delyle S, Guitard F, Naline E, Faisy C, Israel Biet D, et al. Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide. Br J Pharmacol. 2012;165:1877-1890 pubmed 出版商
Bourquin C, Hotz C, Noerenberg D, Voelkl A, Heidegger S, Roetzer L, et al. Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance. Cancer Res. 2011;71:5123-33 pubmed 出版商
Sunters A, Armstrong V, Zaman G, Kypta R, Kawano Y, Lanyon L, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 r. J Biol Chem. 2010;285:8743-58 pubmed 出版商
Wong S, Leung F, Lau C, Au C, Yung L, Yao X, et al. Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res. 2009;104:228-35 pubmed 出版商
Ray N, Bisher M, Enquist L. Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. J Virol. 2004;78:12964-74 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
0942
SKU号 :
0942/10
产品名称 :
NS 398
描述 :
Cyclooxygenase-2 (COX-2) inhibitor
靶标 :
环氧合酶抑制剂
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
314.36
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
NS 398 is a selective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and 100 u M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .
extended description :
Cyclooxygenase-2 (COX-2) inhibitor
化学品名文本 :
N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide
配方 :
C 13 H 18 N 2 O 5秒
配方文本 :
C13H18N2O5S
cas num :
123653-11-2
美元 :
238美元
产品细节 :
Cyclooxygenase-2 (COX-2) inhibitor
储存 :
存放在RT
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国