产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
ICI 182, 780
目录 :
1047
规格 :
1 mg (also 10 mg, 50 mg)
价格 :
103美元
更多信息或购买 :
文章摘录数: 281
参考文献
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Ulhaq Z, Kishida M. Brain Aromatase Modulates Serotonergic Neuron by Regulating Serotonin Levels in Zebrafish Embryos and Larvae. Front Endocrinol (Lausanne). 2018;9:230 pubmed 出版商
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Lu J, Jin P, Gao W, Wang D, Sheng J. Estrogen enhances mismatch repair by induction of MLH1 expression via estrogen receptor-β. Oncotarget. 2017;8:38767-38779 pubmed 出版商
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Zhu Y, Kawaguchi K, Kiyama R. Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors. PLoS ONE. 2017;12:e0171390 pubmed 出版商
Wong C, Au C, Tsang S, Lau C, Yao X, Cai Z, et al. Role of inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in rat aorta. Br J Pharmacol. 2017;174:718-733 pubmed 出版商
Mao C, Livezey M, Kim J, Shapiro D. Antiestrogen Resistant Cell Lines Expressing Estrogen Receptor ? Mutations Upregulate the Unfolded Protein Response and are Killed by BHPI. Sci Rep. 2016;6:34753 pubmed 出版商
Diep C, Ahrendt H, Lange C. Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes. Steroids. 2016;114:48-58 pubmed 出版商
Pastore M, Talwar S, Conley M, Magness R. Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells. Biol Reprod. 2016;94:139 pubmed 出版商
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Peretz J, Pekosz A, Lane A, Klein S. Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors. Am J Physiol Lung Cell Mol Physiol. 2016;310:L415-25 pubmed 出版商
Shappell N, Flythe M, Aiken G. The Effects of Steroid Implant and Dietary Soybean Hulls on Estrogenic Activity of Sera of Steers Grazing Toxic Endophyte-Infected Tall Fescue Pasture. Front Vet Sci. 2015;2:30 pubmed 出版商
Bains M, Roberts J. Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway. Neurosci Lett. 2016;610:79-85 pubmed 出版商
Miyoshi N, Wittner B, Shioda K, Hitora T, Ito T, Ramaswamy S, et al. Nodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulvestrant action and breast cancer prognosis. Oncogenesis. 2015;4:e172 pubmed 出版商
Castro J, Araya G, Inostroza P, Hidalgo P, González Ramos R, Sovino H, et al. Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: estradiol regulation. Biol Res. 2015;48:56 pubmed 出版商
Xu Y, Morse L, da Silva R, Wang D, Battaglino R. A short report: PAMM, a novel antioxidant protein, induced by oxidative stress. Redox Biol. 2015;6:446-453 pubmed 出版商
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Wardell S, Nelson E, Chao C, Alley H, McDonnell D. Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. Endocr Relat Cancer. 2015;22:713-24 pubmed 出版商
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Cook K, Clarke R. Estrogen receptor-α signaling and localization regulates autophagy and unfolded protein response activation in ER+ breast cancer. Receptors Clin Investig. 2014;1: pubmed
Tomita S, Abdalla M, Fujiwara S, Matsumori H, Maehara K, Ohkawa Y, et al. A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation. Nat Commun. 2015;6:6966 pubmed 出版商
Wu Y, Shen Y, Kang K, Zhang Y, Ao F, Wan Y, et al. Effects of estrogen on growth and smooth muscle differentiation of vascular wall-resident CD34(+) stem/progenitor cells. Atherosclerosis. 2015;240:453-61 pubmed 出版商
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Kim S, Markosyan N, Pepe G, Duffy D. Estrogen promotes luteolysis by redistributing prostaglandin F2α receptors within primate luteal cells. Reproduction. 2015;149:453-64 pubmed 出版商
Luzhna L, Lykkesfeldt A, Kovalchuk O. Altered radiation responses of breast cancer cells resistant to hormonal therapy. Oncotarget. 2015;6:1678-94 pubmed
Wang W, Knosp E, Tai G, Zhao Y, Liang Q, Guo Y. Differential effects of estrogen and estrogen receptor antagonist, ICI 182 780, on the expression of calbindin-D9k in rat pituitary prolactinoma GH₃ cells. Int J Clin Exp Pathol. 2014;7:8498-505 pubmed
Zhou Y, Shen J, Xia L, Wang Y. Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling. Cancer Cell Int. 2014;14:540 pubmed 出版商
Hole S, Pedersen A, Hansen S, Lundqvist J, Yde C, Lykkesfeldt A. New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane. Int J Oncol. 2015;46:1481-90 pubmed 出版商
Segovia Mendoza M, Jurado R, Mir R, Medina L, Prado Garcia H, Garcia Lopez P. Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo study. BMC Cancer. 2015;15:21 pubmed 出版商
Albanito L, Lappano R, Madeo A, Chimento A, Prossnitz E, Cappello A, et al. Effects of atrazine on estrogen receptor α- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts. Environ Health Perspect. 2015;123:493-9 pubmed 出版商
Harvey C, Chen J, Bagnell C, Uzumcu M. Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro. Reprod Toxicol. 2015;51:72-8 pubmed 出版商
Yi J, Do I, Jang J, Kim S, Kim K, Park S, et al. Anti-tumor efficacy of fulvestrant in estrogen receptor positive gastric cancer. Sci Rep. 2014;4:7592 pubmed 出版商
Bean J, Hosford S, Symonds L, Owens P, Dillon L, Yang W, et al. The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer. Breast Cancer Res Treat. 2015;149:69-79 pubmed 出版商
Alao J, Michlikova S, Dinér P, Grøtli M, Sunnerhagen P. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014;14:853 pubmed 出版商
Hu R, Warri A, Jin L, Zwart A, Riggins R, Fang H, et al. NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer. Mol Cell Biol. 2015;35:379-90 pubmed 出版商
Gottardo M, Jaita G, Magri M, Zárate S, Moreno Ayala M, Ferraris J, et al. Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis. PLoS ONE. 2014;9:e111548 pubmed 出版商
Fan P, Agboke F, Cunliffe H, Ramos P, Jordan V. A molecular model for the mechanism of acquired tamoxifen resistance in breast cancer. Eur J Cancer. 2014;50:2866-76 pubmed 出版商
Oróstica M, Lopez J, Rojas I, Rocco J, Diaz P, Reuquén P, et al. Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism. Reproduction. 2014;148:285-94 pubmed 出版商
Liang X, Deng W, Li M, Zhao Z, Wang T, Feng X, et al. Egr1 protein acts downstream of estrogen-leukemia inhibitory factor (LIF)-STAT3 pathway and plays a role during implantation through targeting Wnt4. J Biol Chem. 2014;289:23534-45 pubmed 出版商
Kastrati I, Canestrari E, Frasor J. PHLDA1 expression is controlled by an estrogen receptor-NF?B-miR-181 regulatory loop and is essential for formation of ER+ mammospheres. Oncogene. 2015;34:2309-16 pubmed 出版商
Giretti M, Montt Guevara M, Cecchi E, Mannella P, Palla G, Spina S, et al. Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton. Front Endocrinol (Lausanne). 2014;5:80 pubmed 出版商
Colciago A, Ruscica M, Mornati O, Piccolella M, Montagnani Marelli M, Eberini I, et al. In vitro chronic administration of ERbeta selective ligands and prostate cancer cell growth: hypotheses on the selective role of 3beta-adiol in AR-positive RV1 cells. Biomed Res Int. 2014;2014:801473 pubmed 出版商
Myers S, Yang C, Bittner G, Witt K, Tice R, Baird D. Estrogenic and anti-estrogenic activity of off-the-shelf hair and skin care products. J Expo Sci Environ Epidemiol. 2015;25:271-7 pubmed 出版商
Adomas A, Grimm S, Malone C, Takaku M, Sims J, Wade P. Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278 pubmed 出版商
Seo H, Choi Y, Shim J, Yoo I, Ka H. Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs. Biol Reprod. 2014;90:99 pubmed 出版商
Hill B, Muldrew E. Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries. Clin Exp Pharmacol Physiol. 2014;41:430-6 pubmed 出版商
Haagenson K, Zhang J, Xu Z, Shekhar M, Wu G. Functional analysis of MKP-1 and MKP-2 in breast cancer tamoxifen sensitivity. Oncotarget. 2014;5:1101-10 pubmed
Nag S, Mokha S. Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates ?2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat. Neuroscience. 2014;267:122-34 pubmed 出版商
Yonova I, Osborne C, Morrissette N, Jarvo E. Diaryl and heteroaryl sulfides: synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents. J Org Chem. 2014;79:1947-53 pubmed 出版商
Jafaar Z, Litchfield L, Ivanova M, Radde B, Al Rayyan N, Klinge C. β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression. Int J Oncol. 2014;44:1365-75 pubmed 出版商
Choi S, Shin H, Song H, Lim H. Suppression of autophagic activation in the mouse uterus by estrogen and progesterone. J Endocrinol. 2014;221:39-50 pubmed 出版商
Fan P, Agboke F, McDaniel R, Sweeney E, Zou X, Creswell K, et al. Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells. Eur J Cancer. 2014;50:457-68 pubmed 出版商
Park J, Kim D, Ahn H, Song Y, Lee Y, Ryu J. Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia. Biomol Ther (Seoul). 2012;20:183-8 pubmed 出版商
Johansson H, Sanchez B, Mundt F, Forshed J, Kovács A, Panizza E, et al. Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Nat Commun. 2013;4:2175 pubmed 出版商
Smith A, Bosch M, Wagner E, Rønnekleiv O, Kelly M. The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-estradiol. Am J Physiol Endocrinol Metab. 2013;305:E632-40 pubmed 出版商
Greaves E, Collins F, Critchley H, Saunders P. ER?-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1. Hum Reprod. 2013;28:2490-501 pubmed 出版商
Shim M, Lee Y. Estrogen receptor is activated by korean red ginseng in vitro but not in vivo. J Ginseng Res. 2012;36:169-75 pubmed 出版商
Aupperlee M, Leipprandt J, Bennett J, Schwartz R, Haslam S. Amphiregulin mediates progesterone-induced mammary ductal development during puberty. Breast Cancer Res. 2013;15:R44 pubmed 出版商
Zhang X, Diaz M, Yee D. Fulvestrant regulates epidermal growth factor (EGF) family ligands to activate EGF receptor (EGFR) signaling in breast cancer cells. Breast Cancer Res Treat. 2013;139:351-60 pubmed 出版商
Speroni L, Whitt G, Xylas J, Quinn K, Jondeau Cabaton A, Barnes C, et al. Hormonal regulation of epithelial organization in a three-dimensional breast tissue culture model. Tissue Eng Part C Methods. 2014;20:42-51 pubmed 出版商
Morandi A, Martin L, Gao Q, Pancholi S, Mackay A, Robertson D, et al. GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. Cancer Res. 2013;73:3783-95 pubmed 出版商
Giordano G, Tait L, Furlong C, Cole T, Kavanagh T, Costa L. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Free Radic Biol Med. 2013;58:98-108 pubmed 出版商
Aida Yasuoka K, Peoples C, Yasuoka H, Hershberger P, Thiel K, Cauley J, et al. Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis. Arthritis Res Ther. 2013;15:R10 pubmed 出版商
Varea O, Escoll M, Diez H, Garrido J, Wandosell F. Oestradiol signalling through the Akt-mTORC1-S6K1. Biochim Biophys Acta. 2013;1833:1052-64 pubmed 出版商
Lee Y, Kim J, Bae J, Lee J, Kim P, Jang H, et al. Estrogen-like activity of aqueous extract from Agrimonia pilosa Ledeb. in MCF-7 cells. BMC Complement Altern Med. 2012;12:260 pubmed 出版商
Camacho Leal M, Pincini A, Tornillo G, Fiorito E, Bisaro B, Di Luca E, et al. p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. PLoS ONE. 2012;7:e49817 pubmed 出版商
Kim H, Kim Y, Ku S, Kim S, Choi Y, Moon S. The effect of estrogen compounds on human embryoid bodies. Reprod Sci. 2013;20:661-9 pubmed 出版商
Ruiz M, Rigalli J, Arias A, Villanueva S, Banchio C, Vore M, et al. Induction of hepatic multidrug resistance-associated protein 3 by ethynylestradiol is independent of cholestasis and mediated by estrogen receptor. Drug Metab Dispos. 2013;41:275-80 pubmed 出版商
Privette Vinnedge L, Ho S, Wikenheiser Brokamp K, Wells S. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLoS ONE. 2012;7:e46985 pubmed 出版商
Teng Y, Manavalan T, Hu C, Medjakovic S, Jungbauer A, Klinge C. Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells. Toxicol Sci. 2013;131:71-83 pubmed 出版商
Cruz P, Torres C, Ramírez M, Epuñan M, Valladares L, Sierralta W. Proliferation of human mammary cancer cells exposed to 27-hydroxycholesterol. Exp Ther Med. 2010;1:531-536 pubmed
Sievers C, Shanle E, Bradfield C, Xu W. Differential action of monohydroxylated polycyclic aromatic hydrocarbons with estrogen receptors ? and ?. Toxicol Sci. 2013;132:359-67 pubmed 出版商
Mahmoodzadeh S, Pham T, Kuehne A, Fielitz B, Dworatzek E, Kararigas G, et al. 17?-Estradiol-induced interaction of ER? with NPPA regulates gene expression in cardiomyocytes. Cardiovasc Res. 2012;96:411-21 pubmed 出版商
Niu K, Zhang Y, Ro J. Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats. Pain. 2012;153:2283-91 pubmed 出版商
Wen S, Cao G, Bao T, Cheng L, Li H, Du C, et al. Modulation of ovine SBD-1 expression by 17beta-estradiol in ovine oviduct epithelial cells. BMC Vet Res. 2012;8:143 pubmed 出版商
Antoon J, Bratton M, Guillot L, Wadsworth S, Salvo V, Burow M. Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation. Cancer Biol Ther. 2012;13:1026-33 pubmed 出版商
Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ER?) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 pubmed 出版商
Cook K, Shajahan A, Warri A, Jin L, Hilakivi Clarke L, Clarke R. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness. Cancer Res. 2012;72:3337-49 pubmed 出版商
Peretz J, Craig Z, Flaws J. Bisphenol A inhibits follicle growth and induces atresia in cultured mouse antral follicles independently of the genomic estrogenic pathway. Biol Reprod. 2012;87:63 pubmed
Cao D, Ji Y, Tang B, Traub R. Estrogen receptor ? activation is antinociceptive in a model of visceral pain in the rat. J Pain. 2012;13:685-94 pubmed 出版商
Collins Burow B, Antoon J, Frigo D, Elliott S, Weldon C, Boue S, et al. Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha. J Steroid Biochem Mol Biol. 2012;132:186-93 pubmed 出版商
Brion F, Le Page Y, Piccini B, Cardoso O, Tong S, Chung B, et al. Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos. PLoS ONE. 2012;7:e36069 pubmed 出版商
Youn J, Nguyen A, Cai H. Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis. Clin Sci (Lond). 2012;123:509-18 pubmed 出版商
Bobustuc G, Smith J, Maddipatla S, Jeudy S, Limaye A, Isley B, et al. MGMT inhibition restores ER? functional sensitivity to antiestrogen therapy. Mol Med. 2012;18:913-29 pubmed 出版商
Zuloaga K, O Connor D, Handa R, Gonzales R. Estrogen receptor beta dependent attenuation of cytokine-induced cyclooxygenase-2 by androgens in human brain vascular smooth muscle cells and rat mesenteric arteries. Steroids. 2012;77:835-44 pubmed 出版商
Richardson T, Yu A, Wen Y, Yang S, Simpkins J. Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts. PLoS ONE. 2012;7:e34600 pubmed 出版商
Ropero A, Alonso Magdalena P, Soriano S, Juan Pico P, Roepke T, Kelly M, et al. Insulinotropic effect of the non-steroidal compound STX in pancreatic β-cells. PLoS ONE. 2012;7:e34650 pubmed 出版商
Babu P, Si H, Fu Z, Zhen W, Liu D. Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice. J Nutr. 2012;142:724-30 pubmed 出版商
Spink B, Bennett J, Lostritto N, Cole J, Spink D. Expression of the aryl hydrocarbon receptor is not required for the proliferation, migration, invasion, or estrogen-dependent tumorigenesis of MCF-7 breast cancer cells. Mol Carcinog. 2013;52:544-54 pubmed 出版商
Wang Y, Kuehl Kovarik M. Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons. Brain Res. 2012;1436:81-91 pubmed 出版商
González Arenas A, Hansberg Pastor V, Hernández Hernández O, González García T, Henderson Villalpando J, Lemus Hernández D, et al. Estradiol increases cell growth in human astrocytoma cell lines through ER? activation and its interaction with SRC-1 and SRC-3 coactivators. Biochim Biophys Acta. 2012;1823:379-86 pubmed 出版商
Ahn H, Yang H, An B, Choi K, Jeung E. Expression and regulation of Enpp2 in rat uterus during the estrous cycle. J Vet Sci. 2011;12:379-85 pubmed
Rodriguez Ubreva J, Ciudad L, Gomez Cabrero D, Parra M, Bussmann L, di Tullio A, et al. Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes. Nucleic Acids Res. 2012;40:1954-68 pubmed 出版商
Shanle E, Hawse J, Xu W. Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands. Biochem Pharmacol. 2011;82:1940-9 pubmed 出版商
Hsu H, Hu W, Lin Y, Kuo W, Chen L, Chen W, et al. JNK suppression is essential for 17?-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. J Biomed Sci. 2011;18:61 pubmed 出版商
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产品信息
品牌 :
Tocris
master code :
1047
SKU号 :
1047/1
产品名称 :
ICI 182, 780
描述 :
Estrogen receptor antagonist
靶标 :
Estrogen and Related Receptor Antagonists
类别 :
Small Molecules
单位尺寸 :
1 mg (also 10 mg, 50 mg)
纯度 :
99%
观察到的分子量 :
606.77
网址印刷 :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
A high affinity estrogen receptor antagonist (IC50 = 0.29 nM), devoid of any partial agonism both in vitro and in vivo . Also high affinity agonist at the membrane estrogen receptor GPER.
catalog number base :
1047
产品关键词 :
High affinity GPR30 agonist Estrogen receptors antagonists ER ERR ICI182780 AstraZeneca GPER Fulvestrant Estrogen and Related Receptors Estrogen (GPER) Receptors 1047,
extended description :
Estrogen receptor antagonist
化学品名文本 :
7 ,17 -[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
配方 :
C 32 H 47 F 5 O 3秒
配方文本 :
C32H47F5O3S
cas num :
129453-61-8
2020美元 :
98
2021美元 :
103美元
别名 :
Fulvestrant
储存 :
存放在RT
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国