产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
紫杉醇
目录 :
1097/10
规格 :
10 mg (also 50 mg)
价格 :
190美元
更多信息或购买 :
文章摘录数: 28
参考文献
Villalba Riquelme E, de la Torre Martínez R, Fernández Carvajal A, Ferrer Montiel A. Paclitaxel in vitro reversibly sensitizes the excitability of IB4(-) and IB4(+) sensory neurons from male and female rats. Br J Pharmacol. 2022;: pubmed 出版商
Wang D, Hou Q, Zhao L, Gao J, Xiao Y, Wang A. Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol. Oncol Lett. 2019;18:1402-1408 pubmed 出版商
Ayoub N, Al Shami K, Alqudah M, Mhaidat N. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents. Onco Targets Ther. 2017;10:4869-4883 pubmed 出版商
Kyte S, Toma W, Bagdas D, Meade J, SCHURMAN L, Lichtman A, et al. Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN. J Pharmacol Exp Ther. 2018;364:110-119 pubmed 出版商
Wang J, Kong D, Hoerner C, Loncarek J, Stearns T. Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells. elife. 2017;6: pubmed 出版商
Zhang H, Patel A, Wang Y, Zhang Y, Kathawala R, Qiu L, et al. The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors. Mol Cancer Ther. 2017;16:1021-1030 pubmed 出版商
Masocha W. Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice. Peerj. 2016;4:e2702 pubmed
Rennekamp A, Huang X, Wang Y, Patel S, Lorello P, Cade L, et al. ?1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 2016;12:552-8 pubmed 出版商
Masocha W. Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice. Peerj. 2015;3:e1350 pubmed 出版商
Haghshenas B, Nami Y, Haghshenas M, Abdullah N, Rosli R, Radiah D, et al. Bioactivity characterization of Lactobacillus strains isolated from dairy products. Microbiologyopen. 2015;4:803-13 pubmed 出版商
Parvathy S, Masocha W. Coadministration of indomethacin and minocycline attenuates established paclitaxel-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors. Sci Rep. 2015;5:10541 pubmed 出版商
Akita K, Higaki T, Kutsuna N, Hasezawa S. Quantitative analysis of microtubule orientation in interdigitated leaf pavement cells. Plant Signal Behav. 2015;10:e1024396 pubmed 出版商
Kathawala R, Wang Y, Shukla S, Zhang Y, Alqahtani S, Kaddoumi A, et al. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel. Chin J Cancer. 2015;34:115-20 pubmed 出版商
Goldmacher V, Audette C, Guan Y, Sidhom E, Shah J, Whiteman K, et al. High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction. PLoS ONE. 2015;10:e0117523 pubmed 出版商
Vergara D, De Domenico S, Maffia M, Piro G, Di Sansebastiano G. Transgenic plants as low-cost platform for chemotherapeutic drugs screening. Int J Mol Sci. 2015;16:2174-86 pubmed 出版商
Stephan S, Taber A, Jileaeva I, Pegues E, Sentman C, Stephan M. Biopolymer implants enhance the efficacy of adoptive T-cell therapy. Nat Biotechnol. 2015;33:97-101 pubmed 出版商
Kathawala R, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, et al. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 2015;6:510-21 pubmed
Del Nagro C, Xiao Y, Rangell L, Reichelt M, O BRIEN T. Depletion of the central metabolite NAD leads to oncosis-mediated cell death. J Biol Chem. 2014;289:35182-92 pubmed 出版商
Habu T, Matsumoto T. p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs. Springerplus. 2013;2:562 pubmed 出版商
Floyd S, Whiffin N, Gavilan M, Kutscheidt S, De Luca M, Marcozzi C, et al. Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1. J Cell Sci. 2013;126:2845-56 pubmed 出版商
Lin Y, Richards F, Krippendorff B, Bramhall J, Harrington J, Bapiro T, et al. Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells. Br J Cancer. 2012;107:1692-701 pubmed 出版商
Natrajan R, Mackay A, Wilkerson P, Lambros M, Wetterskog D, Arnedos M, et al. Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res. 2012;14:R53 pubmed
Gärtner A, Fornasiero E, Munck S, Vennekens K, Seuntjens E, Huttner W, et al. N-cadherin specifies first asymmetry in developing neurons. EMBO J. 2012;31:1893-903 pubmed 出版商
Hahm E, Hammond D, PROUDFIT H. Substance P induces the reversible formation of varicosities in the dendrites of rat brainstem neurons. Brain Res. 2011;1369:36-45 pubmed 出版商
He M, Zhang Z, Guan C, Xia D, Yuan X. Leading tip drives soma translocation via forward F-actin flow during neuronal migration. J Neurosci. 2010;30:10885-98 pubmed 出版商
Lim S, Choi M, Kim M, Kim J. Alpha-tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells. Exp Mol Med. 2009;41:737-45 pubmed 出版商
Nieto F, Entrena J, Cendan C, Del Pozo E, Vela J, Baeyens J. Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice. Pain. 2008;137:520-531 pubmed 出版商
Pennati M, Campbell A, Curto M, Binda M, Cheng Y, Wang L, et al. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005;4:1328-37 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1097
SKU号 :
1097/10
产品名称 :
紫杉醇
描述 :
Promotes assembly and inhibits disassembly of microtubules
靶标 :
Microtubule Binding Compounds
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
853.92
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Taxol, also known as paclitaxel, promotes and stabilizes tubulin polymerization, causing cell cycle arrest. In CCRF-HSB-2 cells, Taxol induces autocatalytic activation of caspase-10, triggering apoptosis. Taxol is an antitumor agent. In a mouse model of bladder cancer Taxol decreases tumor growth. Taxol also prolongs survival of mice transplanted with human ovarian carcinoma xenografts. Taxol improves neurological outcome and magnetic resonance imaging biomarkers after traumatic brain injury in mice.
extended description :
Promotes assembly and inhibits disassembly of microtubules
化学品名文本 :
[2aR-[2a ,4 ,4a ,6 ,9 ( R*, S*),11 ,12 ,12a ,12b ]]- -(Benzoylamino)- -hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetr
配方 :
C 47 H 51 NO 14
配方文本 :
C47H51NO14
cas num :
33069-62-4
美元 :
190美元
产品细节 :
Promotes assembly and inhibits disassembly of microtubules
别名 :
紫杉醇
储存 :
存放在+4°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国