产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
毛喉素
目录 :
1099/10
规格 :
10 mg (also 50 mg)
价格 :
203美元
更多信息或购买 :
文章摘录数: 85
参考文献
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Ehrlich A, Furuyashiki T, Kitaoka S, Kakizuka A, Narumiya S. Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(??) subunits in human embryonic kidney 293T cells. Mol Pharmacol. 2013;84:476-86 pubmed 出版商
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Byrnes K, Stoica B, Loane D, Riccio A, Davis M, Faden A. Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. Glia. 2009;57:550-60 pubmed 出版商
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产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1099
SKU号 :
1099/10
产品名称 :
毛喉素
描述 :
Adenylyl cyclase activator
靶标 :
Adenylyl Cyclase Activators
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
410.51
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Forskolin, or coleonol, is a cell-permeable, potent, reversible and rapid activator of adenylyl cyclase, an enzyme that converts ATP to cAMP and pyrophosphate (EC50 = 0.5 M). In combination with 5 other compounds, forskolin enables chemical reprogramming of mouse embryonic fibroblasts to pluripotent stem cells, without genetic factors: Valproic acid, sodium salt (Cat. No. 2815), RepSox (Cat. No. 3742), Tranylcypromine hydrochloride (Cat. No. 3852), CHIR 99021 (Cat. No. 4423) and 3-Deazaneplanocin A hydrochloride (Cat. No. 4703). In combination with IBMX (Cat. No. 2845), forskolin induces neural differentiation of mesenchymal stem cells by downregulating neuron restrictive silencer factor. In a rat model of Huntington s disease-like neurodegeneration, forskolin also exhibits neuroprotective effects. Hypotensive and vasodilatory agent. . Water-soluble analog, NKH 477 (Cat. No. 1603), and Forskolin synthesized to Ancillary Material Grade also available. . For more information about how Forskolin may be used, see our protocol: Transdifferentiating Fibroblasts into Neurons.
extended description :
Adenylyl cyclase activator
化学品名文本 :
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
配方 :
C 22 H 34 O 7
配方文本 :
C22H34O7
cas num :
66575-29-9
美元 :
203美元
产品细节 :
Adenylyl cyclase activator
储存 :
存放在-20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国