产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
佛波醇12豆蔻酸13醋酸盐
目录 :
1201/1
规格 :
1 mg (also 5 mg)
价格 :
103美元
更多信息或购买 :
文章摘录数: 28
参考文献
Mestre L, Carrillo Salinas F, Mecha M, Feliú A, Espejo C, Alvarez Cermeño J, et al. Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis. Front Immunol. 2019;10:1374 pubmed 出版商
Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed 出版商
Liu T, Shi Y, Chan M, Peng G, Zhang Q, Sun X, et al. Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Transl Psychiatry. 2018;8:232 pubmed 出版商
Arnold C, Demirel E, Feldner A, Genove G, Zhang H, Sticht C, et al. Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5. FASEB J. 2017;: pubmed 出版商
Quizon P, Sun W, Yuan Y, Midde N, Zhan C, Zhu J. Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport. Sci Rep. 2016;6:39048 pubmed 出版商
Lo Cicero A, Jaskowiak A, Egesipe A, Tournois J, Brinon B, Pitrez P, et al. A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells. Sci Rep. 2016;6:34798 pubmed 出版商
Davis W. The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Curr Alzheimer Res. 2015;12:847-59 pubmed
Tasoglu S, Khoory J, Tekin H, Thomas C, Karnoub A, Ghiran I, et al. Levitational Image Cytometry with Temporal Resolution. Adv Mater. 2015;27:3901-8 pubmed 出版商
Hagen J, Zimmerman R, Goetz C, Bonnevier J, Houchins J, Reagan K, et al. Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays. Cells. 2015;4:84-95 pubmed 出版商
Bemben M, Nguyen Q, Wang T, Li Y, Nicoll R, Roche K. Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses. Proc Natl Acad Sci U S A. 2015;112:2551-6 pubmed 出版商
Brust T, Hayes M, Roman D, Watts V. New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Biochem Pharmacol. 2015;93:85-91 pubmed 出版商
Yu Y, Zhang M, Zhang X, Cai Q, Zhu Z, Jiang W, et al. Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. J Exp Clin Cancer Res. 2014;33:85 pubmed 出版商
Brown M, Dobrikov M, Gromeier M. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. J Virol. 2014;88:13149-60 pubmed 出版商
Li C, Peart N, Xuan Z, Lewis D, Xia Y, Jin J. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism. Cell Signal. 2014;26:1369-78 pubmed 出版商
Walsh T, Berndt M, Carrim N, Cowman J, Kenny D, Metharom P. The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol. 2014;2:178-86 pubmed 出版商
Baba K, Benleulmi Chaachoua A, Journé A, Kamal M, Guillaume J, Dussaud S, et al. Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. Sci Signal. 2013;6:ra89 pubmed 出版商
Gabriel L, Lvov A, Orthodoxou D, Rittenhouse A, Kobertz W, Melikian H. The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3?-dependent, protein kinase C (PKC)-mediated endocytic trafficking. J Biol Chem. 2012;287:32354-66 pubmed
Gao H, Miyata K, Bhaskaran M, Derbenev A, Zsombok A. Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse. Diabetes. 2012;61:1381-90 pubmed 出版商
Kapfhammer J, Gugger O. The analysis of purkinje cell dendritic morphology in organotypic slice cultures. J Vis Exp. 2012;: pubmed 出版商
Sakata I, Park W, Walker A, Piper P, Chuang J, Osborne Lawrence S, et al. Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells. Am J Physiol Endocrinol Metab. 2012;302:E1300-10 pubmed 出版商
Kaszas K, Keller J, Coddou C, Mishra S, Hoon M, Stojilkovic S, et al. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Pharmacol Exp Ther. 2012;340:152-60 pubmed 出版商
Zsombok A, Bhaskaran M, Gao H, Derbenev A, Smith B. Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice. J Neurosci. 2011;31:14024-31 pubmed 出版商
Navaroli D, Stevens Z, Uzelac Z, Gabriel L, King M, Lifshitz L, et al. The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. J Neurosci. 2011;31:13758-70 pubmed 出版商
Specht C, Grünewald N, Pascual O, Rostgaard N, Schwarz G, Triller A. Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C. EMBO J. 2011;30:3842-53 pubmed 出版商
Bohnekamp J, Böselt I, Saalbach A, Tönjes A, Kovacs P, Biebermann H, et al. Involvement of the chemokine-like receptor GPR33 in innate immunity. Biochem Biophys Res Commun. 2010;396:272-7 pubmed 出版商
Nishida H, Tatewaki N, Nakajima Y, Magara T, Ko K, Hamamori Y, et al. Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response. Nucleic Acids Res. 2009;37:5678-89 pubmed 出版商
Jones M, Craik J, Gibbins J, Poole A. Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus. J Biol Chem. 2004;279:40475-83 pubmed
Hirasawa M, Pittman Q. Nifedipine facilitates neurotransmitter release independently of calcium channels. Proc Natl Acad Sci U S A. 2003;100:6139-44 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1201
SKU号 :
1201/1
产品名称 :
佛波醇12豆蔻酸13醋酸盐
描述 :
Protein kinase C activator
靶标 :
Protein Kinase C Activators
类别 :
Small Molecules
单位尺寸 :
1 mg (also 5 mg)
纯度 :
98%
观察到的分子量 :
616.83
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Phorbol 12-myristate 13-acetate is an extensively used phorbol ester high affinity activator of protein kinase C (Ki = 2.6 nM as measured by displacement of [3H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes). It binds to the C1a and C1b domains of PKC inducing membrane translocation of PKC. Phorbol 12-myristate 13-acetate activates the PKC isoforms PKC , - , - , - , - , - , and - but not PKC or - / . Phorbol 12-myristate 13-acetate is a tumor promoter. Phorbol 12-myristate 13-acetate can also induce differentiation of THP-1 monocytes to a macrophage phenotype in vitro .
extended description :
Protein kinase C activator
化学品名文本 :
(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate
配方 :
C 36 H 56 O 8
配方文本 :
C36H56O8
cas num :
16561-29-8
美元 :
103美元
产品细节 :
Protein kinase C activator
别名 :
聚甲基丙烯酸酯
储存 :
存放在-20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国