产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
SB 203580
目录 :
1202/1
规格 :
1 mg (also 10 mg, 50 mg)
价格 :
148美元
更多信息或购买 :
文章摘录数: 106
参考文献
Sanit J, Prompunt E, Adulyaritthikul P, Nokkaew N, Mongkolpathumrat P, Kongpol K, et al. Combination of metformin and p38 MAPK inhibitor, SB203580, reduced myocardial ischemia/reperfusion injury in non-obese type 2 diabetic Goto-Kakizaki rats. Exp Ther Med. 2019;18:1701-1714 pubmed 出版商
Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis. 2019;25:329-344 pubmed
Neamatallah T, Jabbar S, Tate R, Schroeder J, Shweash M, Alexander J, et al. Whole Genome Microarray Analysis of DUSP4-Deletion Reveals A Novel Role for MAP Kinase Phosphatase-2 (MKP-2) in Macrophage Gene Expression and Function. Int J Mol Sci. 2019;20: pubmed 出版商
Moniruzzaman M, Wang R, Jeet V, McGuckin M, Hasnain S. Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway. Int J Mol Sci. 2019;20: pubmed 出版商
Ulzii D, Kido Nakahara M, Nakahara T, Tsuji G, Furue K, Hashimoto Hachiya A, et al. Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in Keratinocytes. Int J Mol Sci. 2019;20: pubmed 出版商
Zhou L, Peng J, Xu Y, Zeng W, Zhang J, Wei X, et al. Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. Cell Rep. 2019;27:3844-3859.e6 pubmed 出版商
Green M, Thayer S. HIV gp120 upregulates tonic inhibition through α5-containing GABAARs. Neuropharmacology. 2019;149:161-168 pubmed 出版商
Kim J, Pajarillo E, Rizor A, Son D, Lee J, Aschner M, et al. LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PLoS ONE. 2019;14:e0210248 pubmed 出版商
Kang Y, Ai Z, Duan K, Si C, Wang Y, Zheng Y, et al. Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys. Cell Rep. 2018;25:2563-2576.e9 pubmed 出版商
Guo Y, Chiu Y, Chen C, Wang H. Interleukin-1β induces CXCR3-mediated chemotaxis to promote umbilical cord mesenchymal stem cell transendothelial migration. Stem Cell Res Ther. 2018;9:281 pubmed 出版商
Andersson P, Yang Y, Hosaka K, Zhang Y, Fischer C, Braun H, et al. Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis. JCI Insight. 2018;3: pubmed 出版商
Simões Sousa S, Littler S, Thompson S, Minshall P, Whalley H, Bakker B, et al. The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α. Cell Rep. 2018;25:749-760.e6 pubmed 出版商
Xing Y, Ming J, Liu T, Zhang N, Zha D, Lin Y. Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment. Yonsei Med J. 2018;59:1131-1137 pubmed 出版商
Lin R, Wu I, Hong J, Liu B, Liang R, Yuan T, et al. Capsaicin-induced TRIB3 upregulation promotes apoptosis in cancer cells. Cancer Manag Res. 2018;10:4237-4248 pubmed 出版商
Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
Wan Q, Liu Z, Yang Y, Cui X. Suppressive effects of berberine on atherosclerosis via downregulating visfatin expression and attenuating visfatin-induced endothelial dysfunction. Int J Mol Med. 2018;41:1939-1948 pubmed 出版商
Singh R, Diwan M, Dastidar S, Najmi A. Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro. Hum Exp Toxicol. 2018;37:521-531 pubmed 出版商
Fish J, Cantu Gutierrez M, Dang L, Khyzha N, Chen Z, Veitch S, et al. Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development. 2017;144:2428-2444 pubmed 出版商
Wu I, Lin R, Wang H, Yuan T, Chuang S. TRIB3 downregulation enhances doxorubicin-induced cytotoxicity in gastric cancer cells. Arch Biochem Biophys. 2017;622:26-35 pubmed 出版商
Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169:243-257.e25 pubmed 出版商
Al Taei S, Salimu J, Spary L, Clayton A, Lester J, Tabi Z. Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer. Oncoimmunology. 2017;6:e1268308 pubmed 出版商
Han H, Liang X, Wang J, Zhao Q, Yang M, Rong W, et al. Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation. Brain Res. 2017;1663:132-140 pubmed 出版商
Chang W, Hwu Y, Xu J, Lin C, Wang S, Cheng A, et al. Derivation of Patient Specific Pluripotent Stem Cells Using Clinically Discarded Cumulus Cells. PLoS ONE. 2016;11:e0165715 pubmed 出版商
Rahman M, Bishayee K, Habib K, Sadra A, Huh S. 18?-Glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis. Biochem Pharmacol. 2016;117:97-112 pubmed 出版商
Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nat Commun. 2016;7:11385 pubmed 出版商
Brosig A, Kuhrt H, Wiedemann P, Kohen L, Bringmann A, Hollborn M. Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA. Mol Vis. 2015;21:1000-16 pubmed
Koerber R, Held S, Heine A, Kotthoff P, Daecke S, Bringmann A, et al. Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma. Exp Hematol Oncol. 2015;4:21 pubmed 出版商
Zebrowski D, Vergarajauregui S, Wu C, Piatkowski T, Becker R, Leone M, et al. Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes. elife. 2015;4: pubmed 出版商
Tang X, Basavarajappa D, Haeggström J, Wan M. P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance. J Immunol. 2015;195:1191-201 pubmed 出版商
Li Y, Zhang H, Kosturakis A, Cassidy R, Zhang H, Kennamer Chapman R, et al. MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy. Brain Behav Immun. 2015;49:255-66 pubmed 出版商
Liu Y, Huang C, Chang C, Chou C, Lin S, Wang I, et al. Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment. Cardiorenal Med. 2015;5:79-88 pubmed 出版商
Cervigni R, Bonavita R, Barretta M, Spano D, Ayala I, Nakamura N, et al. JNK2 controls fragmentation of the Golgi complex and the G2/M transition through phosphorylation of GRASP65. J Cell Sci. 2015;128:2249-60 pubmed 出版商
Aziz M, Yang W, Corbo L, Chaung W, Matsuo S, Wang P. MFG-E8 inhibits neutrophil migration through ?v??-integrin-dependent MAP kinase activation. Int J Mol Med. 2015;36:18-28 pubmed 出版商
Yang H, Long F, Zhang Y, Yu R, Zhang P, Li W, et al. 1?,25-Dihydroxyvitamin D3 Induces Neutrophil Apoptosis through the p38 MAPK Signaling Pathway in Chronic Obstructive Pulmonary Disease Patients. PLoS ONE. 2015;10:e0120515 pubmed 出版商
Hollborn M, Vogler S, Reichenbach A, Wiedemann P, Bringmann A, Kohen L. Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. Mol Vis. 2015;21:360-77 pubmed
Lourenço S, Teixeira V, Kalber T, José R, Floto R, Janes S. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol. 2015;194:3463-74 pubmed 出版商
Okada S, Han S, Patel E, Yang L, Chang L. STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells. Immunol Cell Biol. 2015;93:461-71 pubmed 出版商
Kim M, Lee J, Kim J, Lee L, Yang S, Park B, et al. Decrease of PKB/Akt Phosphorylation is Partially Mediated by SAPK/JNK Activation in Serum-free L6 Myoblasts Starved with Low Glucose. J Phys Ther Sci. 2014;26:1757-60 pubmed 出版商
Yu Y, Yip K, Tam I, Sam S, Ng C, Zhang W, et al. Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. PLoS ONE. 2014;9:e112989 pubmed 出版商
Caldwell A, Cheng Z, Vargas J, Birnbaum H, Hoffmann A. Network dynamics determine the autocrine and paracrine signaling functions of TNF. Genes Dev. 2014;28:2120-33 pubmed 出版商
Wei S, Zhang Z, Yu Y, Felder R. Central SDF-1/CXCL12 expression and its cardiovascular and sympathetic effects: the role of angiotensin II, TNF-α, and MAP kinase signaling. Am J Physiol Heart Circ Physiol. 2014;307:H1643-54 pubmed 出版商
Beermann S, Vauth M, Hein R, Seifert R, Neumann D. Distinct signalling pathways of murine histamine H1- and H4-receptors expressed at comparable levels in HEK293 cells. PLoS ONE. 2014;9:e107481 pubmed 出版商
Davis T, Tivey H, Brook A, Kipling D. Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBN(p70) protein undergo p38/MK2-dependent premature senescence. Biogerontology. 2015;16:43-51 pubmed 出版商
Liang J, Chao D, Sandhu H, Yu Y, Zhang L, Balboni G, et al. ?-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes. Br J Pharmacol. 2014;171:5417-30 pubmed 出版商
Wan M, Soehnlein O, Tang X, van der Does A, Smedler E, Uhlen P, et al. Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo. FASEB J. 2014;28:3456-67 pubmed 出版商
Heckler M, Thakor H, Schafer C, Riggins R. ERK/MAPK regulates ERR? expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer. FEBS J. 2014;281:2431-42 pubmed 出版商
Bae J, Ricciardi C, Esposito D, Komarnytsky S, Hu P, Curry B, et al. Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration. Am J Physiol Cell Physiol. 2014;306:C918-30 pubmed 出版商
Kim M, Yun H, Kim D, Kang I, Choe W, Kim S, et al. AMP-activated protein kinase determines apoptotic sensitivity of cancer cells to ginsenoside-Rh2. J Ginseng Res. 2014;38:16-21 pubmed 出版商
Bernet J, Doles J, Hall J, Kelly Tanaka K, Carter T, Olwin B. p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Nat Med. 2014;20:265-71 pubmed 出版商
Enomoto T, Ohashi K, Shibata R, Kambara T, Uemura Y, Yuasa D, et al. Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 15. PLoS ONE. 2013;8:e83183 pubmed 出版商
Choi J, Devkota S, Sung Y, Lee H. EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-?B activity. Oncotarget. 2013;4:2383-96 pubmed
Gonsalves C, Crable S, Chandra S, Li W, Kalra V, Joiner C. Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1?. Am J Hematol. 2014;89:273-81 pubmed 出版商
Suk F, Lien G, Huang W, Chen C, Lu S, Yang Y, et al. A Taiwanese Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in Human Hepatoma Cells. Evid Based Complement Alternat Med. 2013;2013:658370 pubmed 出版商
Gafni O, Weinberger L, Mansour A, Manor Y, Chomsky E, Ben Yosef D, et al. Derivation of novel human ground state naive pluripotent stem cells. Nature. 2013;504:282-6 pubmed 出版商
Lang E, Modicano P, Arnold M, Bissinger R, Faggio C, Abed M, et al. Effect of thioridazine on erythrocytes. Toxins (Basel). 2013;5:1918-31 pubmed 出版商
Marlow R, Honeth G, Lombardi S, Cariati M, Hessey S, Pipili A, et al. A novel model of dormancy for bone metastatic breast cancer cells. Cancer Res. 2013;73:6886-99 pubmed 出版商
Kook S, Jeon Y, Lim S, Jang M, Cho E, Lee S, et al. Fibroblast growth factor-4 enhances proliferation of mouse embryonic stem cells via activation of c-Jun signaling. PLoS ONE. 2013;8:e71641 pubmed 出版商
Kim H, Montana V, Jang H, Parpura V, Kim J. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation. J Biol Chem. 2013;288:22693-705 pubmed 出版商
Sethi A, Wordinger R, Clark A. Gremlin utilizes canonical and non-canonical TGF? signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. Exp Eye Res. 2013;113:117-27 pubmed 出版商
Keasey M, Kang S, Lovins C, Hagg T. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal. 2013;11:35 pubmed 出版商
Koeglsperger T, Li S, Brenneis C, Saulnier J, Mayo L, Carrier Y, et al. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-?1 in the CNS. Glia. 2013;61:985-1002 pubmed 出版商
Jensen K, Garmaroudi F, Zhang J, Lin J, Boroomand S, Zhang M, et al. An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection. Cell Host Microbe. 2013;13:67-76 pubmed 出版商
Katholnig K, Kaltenecker C, Hayakawa H, Rosner M, Lassnig C, Zlabinger G, et al. p38? senses environmental stress to control innate immune responses via mechanistic target of rapamycin. J Immunol. 2013;190:1519-27 pubmed 出版商
Cai W, Rudolph J, Sengoku T, Andres D. Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway. Neurosci Lett. 2012;531:125-30 pubmed 出版商
Siegl S, Uhlig S. Using the one-lung method to link p38 to pro-inflammatory gene expression during overventilation in C57BL/6 and BALB/c mice. PLoS ONE. 2012;7:e41464 pubmed 出版商
Ju W, Zhihong Y, Zhiyou Z, Qin H, Dingding W, Li S, et al. Inhibition of ?-SMA by the ectodomain of FGFR2c attenuates lung fibrosis. Mol Med. 2012;18:992-1002 pubmed 出版商
Santos D, Xavier J, Morgado A, Sola S, Rodrigues C. Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation. PLoS ONE. 2012;7:e33468 pubmed 出版商
Yi L, Chandrasekaran P, Venkatesan S. TLR signaling paralyzes monocyte chemotaxis through synergized effects of p38 MAPK and global Rap-1 activation. PLoS ONE. 2012;7:e30404 pubmed 出版商
Gardoni F, Saraceno C, Malinverno M, Marcello E, Verpelli C, Sala C, et al. The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway. J Cell Sci. 2012;125:1401-6 pubmed 出版商
Trendelenburg A, Meyer A, Jacobi C, Feige J, Glass D. TAK-1/p38/nNF?B signaling inhibits myoblast differentiation by increasing levels of Activin A. Skelet Muscle. 2012;2:3 pubmed 出版商
Khuituan P, Teerapornpuntakit J, Wongdee K, Suntornsaratoon P, Konthapakdee N, Sangsaksri J, et al. Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D?-enhanced duodenal calcium transport in male mice. Am J Physiol Endocrinol Metab. 2012;302:E903-13 pubmed 出版商
Meotti F, Campos R, da Silva K, Paszcuk A, Costa R, Calixto J. Inflammatory muscle pain is dependent on the activation of kinin B? and B? receptors and intracellular kinase pathways. Br J Pharmacol. 2012;166:1127-39 pubmed 出版商
Isfort K, Ebert F, Bornhorst J, Sargin S, Kardakaris R, Pasparakis M, et al. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. J Biol Chem. 2011;286:44776-87 pubmed 出版商
Tsai C, Lin C, Wang Y. Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway. J Nutr. 2011;141:2119-25 pubmed 出版商
Kovac A, Erickson M, Banks W. Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J Neuroinflammation. 2011;8:139 pubmed 出版商
Kim J, Lee J, Kim S, Choi Y, Lee W, Jeong M, et al. Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells. Korean J Physiol Pharmacol. 2011;15:211-6 pubmed 出版商
Suh B, Jung J, Park N, Seong C, Im H, Kwon Y, et al. Induction of steroid sulfatase expression by tumor necrosis factor-? through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells. Exp Mol Med. 2011;43:646-52 pubmed 出版商
Chen L, Sooranna S, Lei K, Kandola M, Bennett P, Liang Z, et al. Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells. J Cell Mol Med. 2012;16:1447-60 pubmed 出版商
Zhou L, Too H. Mitochondrial localized STAT3 is involved in NGF induced neurite outgrowth. PLoS ONE. 2011;6:e21680 pubmed 出版商
Makhortova N, Hayhurst M, Cerqueira A, Sinor Anderson A, Zhao W, Heiser P, et al. A screen for regulators of survival of motor neuron protein levels. Nat Chem Biol. 2011;7:544-52 pubmed 出版商
Sethi A, Jain A, Zode G, Wordinger R, Clark A. Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins. Invest Ophthalmol Vis Sci. 2011;52:5251-9 pubmed 出版商
Kang J, Lee E, Park S, Chung I. MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways. J Immunol. 2011;187:222-9 pubmed 出版商
Hecker L, Jagirdar R, Jin T, Thannickal V. Reversible differentiation of myofibroblasts by MyoD. Exp Cell Res. 2011;317:1914-21 pubmed 出版商
Zhou H, Huang X, Cui H, Luo X, Tang Y, Chen S, et al. miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells. Blood. 2010;116:5885-94 pubmed 出版商
Yoo D, Kim C, Lee S, Kim H, Cho E, Park M, et al. Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells. Korean J Physiol Pharmacol. 2010;14:139-44 pubmed 出版商
Pera T, Gosens R, Lesterhuis A, Sami R, van der Toorn M, Zaagsma J, et al. Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype. Respir Res. 2010;11:48 pubmed 出版商
Novoyatleva T, Diehl F, van Amerongen M, Patra C, Ferrazzi F, Bellazzi R, et al. TWEAK is a positive regulator of cardiomyocyte proliferation. Cardiovasc Res. 2010;85:681-90 pubmed 出版商
Yeligar S, Machida K, Tsukamoto H, Kalra V. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol. 2009;183:5964-76 pubmed 出版商
Doulatov S, Notta F, Rice K, Howell L, Zelent A, Licht J, et al. PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes Dev. 2009;23:2076-87 pubmed 出版商
Steubesand N, Kiehne K, Brunke G, Pahl R, Reiss K, Herzig K, et al. The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis. BMC Immunol. 2009;10:36 pubmed 出版商
Sutcliffe A, Clarke D, Bradbury D, Corbett L, Patel J, Knox A. Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1. Br J Pharmacol. 2009;157:436-50 pubmed 出版商
Davis T, Kipling D. Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of ataxia telangiectasia and Werner syndrome fibroblasts. Biogerontology. 2009;10:253-66 pubmed 出版商
Coba M, Valor L, Kopanitsa M, Afinowi N, Grant S. Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus. J Biol Chem. 2008;283:34101-7 pubmed 出版商
Wei S, Yu Y, Zhang Z, Weiss R, Felder R. Mitogen-activated protein kinases mediate upregulation of hypothalamic angiotensin II type 1 receptors in heart failure rats. Hypertension. 2008;52:679-86 pubmed 出版商
Jung S, Yang W, Kim J, Kim H, Kim E, Yun H, et al. Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis. 2008;29:713-21 pubmed 出版商
Toyoda H, Zhao M, Xu H, Wu L, Ren M, Zhuo M. Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex. Mol Pain. 2007;3:36 pubmed
Zhou J, Yu D, Cheng J, Shapiro D. Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death. Steroids. 2007;72:765-77 pubmed
Schlee M, Wehkamp J, Altenhoefer A, Oelschlaeger T, Stange E, Fellermann K. Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin. Infect Immun. 2007;75:2399-407 pubmed
Katiyar S, Jiao X, Wagner E, Lisanti M, Pestell R. Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor. Mol Cell Biol. 2007;27:1356-69 pubmed
Alao J, Stavropoulou A, Lam E, Coombes R. Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. Mol Cancer. 2006;5:40 pubmed
O Riordan K, Huang I, Pizzi M, Spano P, Boroni F, Egli R, et al. Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors. J Neurosci. 2006;26:4870-9 pubmed
Kauppinen T, Chan W, Suh S, Wiggins A, Huang E, Swanson R. Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc Natl Acad Sci U S A. 2006;103:7136-41 pubmed
Sunters A, Madureira P, Pomeranz K, Aubert M, Brosens J, Cook S, et al. Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. Cancer Res. 2006;66:212-20 pubmed
Aiston S, Hampson L, Arden C, Iynedjian P, Agius L. The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes. Diabetologia. 2006;49:174-82 pubmed
Tyszkiewicz J, Yan Z. beta-Amyloid peptides impair PKC-dependent functions of metabotropic glutamate receptors in prefrontal cortical neurons. J Neurophysiol. 2005;93:3102-11 pubmed
Gallagher S, Daly C, Bear M, Huber K. Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1. J Neurosci. 2004;24:4859-64 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1202
SKU号 :
1202/1
产品名称 :
SB 203580
描述 :
Selective inhibitor of p38 MAPK
靶标 :
p38 Inhibitors
类别 :
Small Molecules
单位尺寸 :
1 mg (also 10 mg, 50 mg)
纯度 :
98%
观察到的分子量 :
377.44
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
SB 203580 is a selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3 and PKB . Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. SB 203580 is an essential component of medium for maintaining stem cells in naive pluripotent state and can be used to promote expansion of HSCs ex vivo . . Water-soluble Salt also available.
extended description :
Selective inhibitor of p38 MAPK
化学品名文本 :
4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
配方 :
C 21 H 16 FN 3 OS
配方文本 :
C21H16FN3OS
cas num :
152121-47-6
美元 :
148美元
产品细节 :
Selective inhibitor of p38 MAPK
储存 :
存放在+4°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国