产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
SB 224289 hydrochloride
目录 :
1221/10
规格 :
10 mg (also 50 mg)
价格 :
264美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 8
参考文献
Hirono M, Nagao S, Yanagawa Y, Konishi S. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology. 2017;118:79-89 pubmed 出版商
Cassilly C, Maddox M, Cherian P, Bowling J, Hamann M, Lee R, et al. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. PLoS ONE. 2016;11:e0154932 pubmed 出版商
Baillie L, Ahn A, Mulligan S. Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. Neuropharmacology. 2012;63:362-7 pubmed 出版商
Morecroft I, White K, Caruso P, Nilsen M, Loughlin L, Alba R, et al. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. Mol Ther. 2012;20:1516-28 pubmed 出版商
Murray K, Stephens M, Rank M, D Amico J, Gorassini M, Bennett D. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011;106:925-43 pubmed 出版商
Hampson L, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 2007;50:1743-51 pubmed
Siddiqui E, Shabbir M, Mikhailidis D, Thompson C, Mumtaz F. The role of serotonin (5-hydroxytryptamine1A and 1B) receptors in prostate cancer cell proliferation. J Urol. 2006;176:1648-53 pubmed
Heisler L, Jobst E, Sutton G, Zhou L, Borok E, Thornton Jones Z, et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006;51:239-49 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1221
SKU号 :
1221/10
产品名称 :
SB 224289 hydrochloride
描述 :
Selective 5-HT1B antagonist
靶标 :
5-HT1B Receptor Antagonists
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
95%
观察到的分子量 :
557.09
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
SB 224289 hydrochloride is a selective 5-HT1B receptor antagonist (pKi = 8.2). Displays 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo .
extended description :
Selective 5-HT1B antagonist
化学品名文本 :
1 -Methyl-5-[[2 -methyl-4 -(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4 -piperidine hydrochloride
配方 :
C 32 H 32 N 4 O 3。 氯化氢
配方文本 :
C32H32N4O3.氯化氢
cas num :
180084-26-8
美元 :
264美元
产品细节 :
Selective 5-HT1B antagonist
储存 :
存放在-20°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国