产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
NF 023
目录 :
1240/10
规格 :
10 mg (also 50 mg)
价格 :
212美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 10
参考文献
Su L, Bryan N, Battista S, Freitas J, Garabedian A, D Alessio F, et al. Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci Rep. 2020;10:18850 pubmed 出版商
Gao J, Xin W, Huang J, Ji B, Gao S, Chen L, et al. Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors. Virulence. 2018;9:1601-1614 pubmed 出版商
Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, et al. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 2015;11:e1005184 pubmed 出版商
Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, et al. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016;213:456-64 pubmed 出版商
Ren P, Zou G, Bailly B, Xu S, Zeng M, Chen X, et al. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo. Emerg Microbes Infect. 2014;3:e62 pubmed 出版商
Beckham T, Cheng J, Lu P, Shao Y, Troyer D, Lance R, et al. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis. 2013;2:e49 pubmed 出版商
Manohar M, Hirsh M, Chen Y, Woehrle T, Karande A, Junger W. ATP release and autocrine signaling through P2X4 receptors regulate ?? T cell activation. J Leukoc Biol. 2012;92:787-94 pubmed 出版商
Donnelly Roberts D, Namovic M, Han P, Jarvis M. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol. 2009;157:1203-14 pubmed 出版商
Gallego D, Gil V, Aleu J, Aulí M, Clave P, Jiménez M. Purinergic and nitrergic junction potential in the human colon. Am J Physiol Gastrointest Liver Physiol. 2008;295:G522-33 pubmed 出版商
Labrakakis C, Tong C, Weissman T, Torsney C, Macdermott A. Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat. J Physiol. 2003;549:131-42 pubmed
产品信息
品牌 :
Tocris
master code :
1240
SKU号 :
1240/10
产品名称 :
NF 023
描述 :
Selective and competitive P2X1 antagonist
靶标 :
P2X Receptor Antagonists
类别 :
Small Molecules
sizes available :
10 mg (also 50 mg)
观察到的分子量 :
1162.86
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
NF 023 is an a subtype-selective, competitive and reversible P2X1 receptor antagonist. Displays IC50 values of 0.21, 28.9, 50 and 100 u M for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the -subunit of Go/i (EC50 ~300 nM). Also inhibits DNA-binding activity of HMGA2 (IC50 = 10.63 M).
extended description :
Selective and competitive P2X1 antagonist
化学品名文本 :
8,8 -[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt
配方 :
C 35 H 20 N 4 Na 6 O 21 S 6
配方文本 :
C35H20N4Na6O21S6
cas num :
104869-31-0
美元 :
201
美元2023 :
212美元
产品细节 :
Selective and competitive P2X1 antagonist
储存 :
Desiccate at RT
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国