产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
KB-R7943甲磺酸
目录 :
1244/10
规格 :
10 mg (also 50 mg)
价格 :
229美元
更多信息或购买 :
文章摘录数: 42
参考文献
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Hernandez Ojeda M, Ureña Guerrero M, Gutierrez Barajas P, Cardenas Castillo J, Camins A, Beas Zarate C. KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment. J Biomed Sci. 2017;24:27 pubmed 出版商
Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017;93:587-605.e7 pubmed 出版商
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Sabourin J, Bartoli F, Antigny F, Gomez A, Benitah J. Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES. J Biol Chem. 2016;291:13394-409 pubmed 出版商
Virsolvy A, Farah C, Pertuit N, Kong L, Lacampagne A, Reboul C, et al. Antagonism of Nav channels and α1-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine. Sci Rep. 2015;5:17969 pubmed 出版商
Vinberg F, Wang T, Molday R, Chen J, Kefalov V. A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. Hum Mol Genet. 2015;24:5915-29 pubmed 出版商
Wang Y, Chen Y, Cheng R, Huang R. Role of Na⁺/Ca²⁺ exchanger in Ca²⁺ homeostasis in rat suprachiasmatic nucleus neurons. J Neurophysiol. 2015;113:2114-26 pubmed 出版商
Bobkov Y, Corey E, Ache B. An inhibitor of Na(+)/Ca(2+) exchange blocks activation of insect olfactory receptors. Biochem Biophys Res Commun. 2014;450:1104-9 pubmed 出版商
Drumm B, Sergeant G, Hollywood M, Thornbury K, Matsuda T, Baba A, et al. The effect of high [K(+)]o on spontaneous Ca(2+) waves in freshly isolated interstitial cells of Cajal from the rabbit urethra. Physiol Rep. 2014;2:e00203 pubmed 出版商
Cuozzo F, Raciti M, Bertelli L, Parente R, Di Renzo L. Pro-death and pro-survival properties of ouabain in U937 lymphoma derived cells. J Exp Clin Cancer Res. 2012;31:95 pubmed 出版商
Yamamura A, Guo Q, Yamamura H, Zimnicka A, Pohl N, Smith K, et al. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ Res. 2012;111:469-81 pubmed 出版商
Pandit M, Strait K, Matsuda T, Kohan D. Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production. Am J Physiol Renal Physiol. 2012;302:F1325-30 pubmed 出版商
Chouhan A, Ivannikov M, Lu Z, Sugimori M, Llinas R, MacLeod G. Cytosolic calcium coordinates mitochondrial energy metabolism with presynaptic activity. J Neurosci. 2012;32:1233-43 pubmed 出版商
Yoshizumi M, Eisenach J, Hayashida K. Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes. Eur J Pharmacol. 2012;677:87-92 pubmed 出版商
Cheng H, Zhang Y, Du C, Dempsey C, Hancox J. High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943. Br J Pharmacol. 2012;165:2260-73 pubmed 出版商
Pan W, Borovac J, Spicer Z, Hoenderop J, Bindels R, Shull G, et al. The epithelial sodium/proton exchanger, NHE3, is necessary for renal and intestinal calcium (re)absorption. Am J Physiol Renal Physiol. 2012;302:F943-56 pubmed 出版商
Roberts D, Matsuda T, Bose R. Molecular and functional characterization of the human platelet Na(+) /Ca(2+) exchangers. Br J Pharmacol. 2012;165:922-36 pubmed 出版商
Poteser M, Schleifer H, Lichtenegger M, Schernthaner M, Stockner T, Kappe C, et al. PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes. Proc Natl Acad Sci U S A. 2011;108:10556-61 pubmed 出版商
Xu K, Zhu W, Chen L, deFilippi C, Zhang J, Xiao R. Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPase-mediated Ca2+ influx in cardiomyocytes. Biochem Biophys Res Commun. 2011;406:200-3 pubmed 出版商
Cheng H, Smith G, Hancox J, Orchard C. Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca(2+) ATPase. Cell Calcium. 2011;49:56-65 pubmed 出版商
Hamming K, Soliman D, Webster N, Searle G, Matemisz L, Liknes D, et al. Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion. Diabetes. 2010;59:1686-93 pubmed 出版商
Kim C, Majdi M, Xia P, Wei K, Talantova M, Spiering S, et al. Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation. Stem Cells Dev. 2010;19:783-95 pubmed 出版商
Barrientos G, Bose D, Feng W, Padilla I, Pessah I. The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. Mol Pharmacol. 2009;76:560-8 pubmed 出版商
Chao D, Balboni G, Lazarus L, Salvadori S, Xia Y. Na+ mechanism of delta-opioid receptor induced protection from anoxic K+ leakage in the cortex. Cell Mol Life Sci. 2009;66:1105-15 pubmed 出版商
Pezier A, Bobkov Y, Ache B. The Na+/Ca2+ exchanger inhibitor, KB-R7943, blocks a nonselective cation channel implicated in chemosensory transduction. J Neurophysiol. 2009;101:1151-9 pubmed 出版商
Poburko D, Liao C, van Breemen C, Demaurex N. Mitochondrial regulation of sarcoplasmic reticulum Ca2+ content in vascular smooth muscle cells. Circ Res. 2009;104:104-12 pubmed 出版商
Xu Y, Tappia P, Goyal R, Dhalla N. Mechanisms of the lysophosphatidic acid-induced increase in [Ca(2+)](i) in skeletal muscle cells. J Cell Mol Med. 2008;12:942-54 pubmed 出版商
Baltan S, Besancon E, Mbow B, Ye Z, Hamner M, Ransom B. White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity. J Neurosci. 2008;28:1479-89 pubmed 出版商
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Algara Suárez P, Romero Méndez C, Chrones T, Sánchez Armass S, Meza U, Sims S, et al. Functional coupling between the Na+/Ca2+ exchanger and nonselective cation channels during histamine stimulation in guinea pig tracheal smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2007;293:L191-8 pubmed
Takeuchi A, Tatsumi S, Sarai N, Terashima K, Matsuoka S, Noma A. Ionic mechanisms of cardiac cell swelling induced by blocking Na+/K+ pump as revealed by experiments and simulation. J Gen Physiol. 2006;128:495-507 pubmed
Honda E, Ono K, Kataoka S, Inenaga K. Activation of subfornical organ neurons in rats through pre- and postsynaptic alpha-adrenoceptors. Am J Physiol Regul Integr Comp Physiol. 2006;290:R1646-53 pubmed
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Kohlmeier K, Inoue T, Leonard C. Hypocretin/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum. J Neurophysiol. 2004;92:221-35 pubmed
Spencer C, Sham J. Effects of Na+/Ca2+ exchange induced by SR Ca2+ release on action potentials and afterdepolarizations in guinea pig ventricular myocytes. Am J Physiol Heart Circ Physiol. 2003;285:H2552-62 pubmed
Su Y, Vacquier V. A flagellar K(+)-dependent Na(+)/Ca(2+) exchanger keeps Ca(2+) low in sea urchin spermatozoa. Proc Natl Acad Sci U S A. 2002;99:6743-8 pubmed 出版商
Vines C, Yoshida K, Griffin F, Pillai M, Morisawa M, Yanagimachi R, et al. Motility initiation in herring sperm is regulated by reverse sodium-calcium exchange. Proc Natl Acad Sci U S A. 2002;99:2026-31 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1244
SKU号 :
1244/10
产品名称 :
KB-R7943甲磺酸
描述 :
Na+/Ca2+ exchange inhibitor (reverse mode)
靶标 :
Na+/Ca2+ Exchanger Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
427.49
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
KB-R7943 mesylate is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 M). Also inhibits the mitochondrial Ca2+ uniporter (MCU; IC50 = 5.5 M). Does not affect Na+-dependent transport systems or ionotropic glutamate receptors.
extended description :
Na+/Ca2+ exchange inhibitor (reverse mode)
化学品名文本 :
2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate
配方 :
C 16 H 17 N 3 O 3 secondsCH 3 SO 3 H
配方文本 :
C16H17N3O3S.CH3SO3H
cas num :
182004-65-5
美元 :
229美元
产品细节 :
Na+/Ca2+ exchange inhibitor (reverse mode)
储存 :
存放在RT
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国