产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
Pifithrin-a hydrobromide
目录 :
1267
规格 :
10 mg (also 50 mg)
价格 :
173美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 4
参考文献
Li H, Zhang J, Niswander L. Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Development. 2018;145: pubmed 出版商
Norlin S, Parekh V, Edlund H. The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018;145: pubmed 出版商
Guha G, Lu W, Li S, Liang X, Kulesz Martin M, Mahmud T, et al. Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells. PLoS ONE. 2015;10:e0125322 pubmed 出版商
Fraser M, Chan S, Chan S, Fiscus R, Tsang B. Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells. Oncogene. 2006;25:2203-12 pubmed
产品信息
品牌 :
Tocris
master code :
1267
SKU号 :
1267/10
产品名称 :
Pifithrin-a hydrobromide
描述 :
p53 inhibitor. Also aryl hydrocarbon receptor agonist
靶标 :
p53 Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
观察到的分子量 :
367.3
网址印刷 :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo ; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 u M). Cyclic analog available (Cat. No. 3843).
catalog number base :
1267
产品关键词 :
p53 inhibitors inhibits aryl hydrocarbon receptors agonists AHR Transcription Factors Pifithrin-alpha hydrobromide p53 Aryl Hydrocarbon Receptors Stem Cell Signaling Autophagy 1267,
extended description :
p53 inhibitor. Also aryl hydrocarbon receptor agonist
化学品名文本 :
1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
配方 :
C 16 H 18 N 2 OS.HBr
配方文本 :
C16H18N2OS.HBr
cas num :
63208-82-2
2020美元 :
166
2021美元 :
173美元
储存 :
Desiccate at -20°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国