产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
AG 1478 hydrochloride
目录 :
1276/10
规格 :
10 mg (also 50 mg)
价格 :
229美元
更多信息或购买 :
文章摘录数: 20
参考文献
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Hosseini Z, Nelson D, Moskwa N, Sfakis L, Castracane J, Larsen M. FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids. J Cell Sci. 2018;131: pubmed 出版商
Gillman A, Breshears L, Kistler C, Finnegan P, Torres V, Schlievert P, et al. Epidermal Growth Factor Receptor Signaling Enhances the Proinflammatory Effects of Staphylococcus aureus Gamma-Toxin on the Mucosa. Toxins (Basel). 2017;9: pubmed 出版商
Zhu J, Li K, Cao S, Chen X, Shen C, Zhang Y, et al. Increased NRG1-ErbB4 signaling in human symptomatic epilepsy. Sci Rep. 2017;7:141 pubmed 出版商
Leonetti C, Macrez R, Pruvost M, Hommet Y, Bronsard J, Fournier A, et al. Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination. Mol Neurodegener. 2017;12:20 pubmed 出版商
Breshears L, Gillman A, Stach C, Schlievert P, Peterson M. Local Epidermal Growth Factor Receptor Signaling Mediates the Systemic Pathogenic Effects of Staphylococcus aureus Toxic Shock Syndrome. PLoS ONE. 2016;11:e0158969 pubmed 出版商
Bertrand T, Lesept F, Chevilley A, Lenoir S, Aimable M, Briens A, et al. Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR. Cell Death Dis. 2015;6:e1924 pubmed 出版商
Mathew L, Huangyang P, Mucaj V, Lee S, Skuli N, Eisinger Mathason T, et al. Feedback circuitry between miR-218 repression and RTK activation in glioblastoma. Sci Signal. 2015;8:ra42 pubmed 出版商
Ledonne A, Nobili A, Latagliata E, Cavallucci V, Guatteo E, Puglisi Allegra S, et al. Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons. Mol Psychiatry. 2015;20:959-73 pubmed 出版商
Pandya C, Pillai A. TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis. Cell Commun Signal. 2014;12:47 pubmed 出版商
Bayliss A, Evans P. Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-dopamine-like G protein-coupled receptor. PLoS ONE. 2013;8:e80833 pubmed 出版商
Voon D, Wang H, Koo J, Chai J, Hor Y, Tan T, et al. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway. PLoS ONE. 2013;8:e70427 pubmed 出版商
Akhtar S, Yousif M, Dhaunsi G, Sarkhouh F, Chandrasekhar B, Attur S, et al. Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction. PLoS ONE. 2013;8:e67813 pubmed 出版商
Ayoub M, See H, Seeber R, Armstrong S, Pfleger K. Profiling epidermal growth factor receptor and heregulin receptor 3 heteromerization using receptor tyrosine kinase heteromer investigation technology. PLoS ONE. 2013;8:e64672 pubmed 出版商
Breshears L, Schlievert P, Peterson M. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem. 2012;287:32578-87 pubmed
O Keeffe G, Tyers P, Aarsland D, Dalley J, Barker R, Caldwell M. Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc Natl Acad Sci U S A. 2009;106:8754-9 pubmed 出版商
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产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1276
SKU号 :
1276/10
产品名称 :
AG 1478 hydrochloride
描述 :
Highly potent EGFR-kinase inhibitor
靶标 :
EGF Receptor Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
352.22
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
AG 1478 hydrochloride is a potent and selective inhibitor of epidermal growth factor receptor kinase (IC50 values 3 nM for EGFR and 100 u M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC50 = 1 M).
extended description :
Highly potent EGFR-kinase inhibitor
化学品名文本 :
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride
配方 :
C 16 H 14 ClN 3 O 2 .HCl
配方文本 :
C16H14ClN3O2.氯化氢
cas num :
170449-18-0
美元 :
229美元
产品细节 :
Highly potent EGFR-kinase inhibitor
别名 :
一类酪氨酸激酶抑制剂老化1478
储存 :
Desiccate at -20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国