产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
AG 1478 hydrochloride
目录 :
1276/10
规格 :
10 mg (also 50 mg)
价格 :
229美元
更多信息或购买 :
文章摘录数: 20
参考文献 |
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Breshears L, Schlievert P, Peterson M. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem. 2012;287:32578-87 pubmed
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Fang Y, Ferrie A, Fontaine N, Mauro J, Balakrishnan J. Resonant waveguide grating biosensor for living cell sensing. Biophys J. 2006;91:1925-40 pubmed
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Belcher S, Le H, Spurling L, Wong J. Rapid estrogenic regulation of extracellular signal- regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A. Endocrinology. 2005;146:5397-406 pubmed
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Maggiolini M, Vivacqua A, Fasanella G, Recchia A, Sisci D, Pezzi V, et al. The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004;279:27008-16 pubmed
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Atherton H, Jones G, Danahay H. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol. 2003;285:L730-9 pubmed
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产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1276
SKU号 :
1276/10
产品名称 :
AG 1478 hydrochloride
描述 :
Highly potent EGFR-kinase inhibitor
靶标 :
EGF Receptor Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
352.22
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
AG 1478 hydrochloride is a potent and selective inhibitor of epidermal growth factor receptor kinase (IC50 values 3 nM for EGFR and 100 u M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC50 = 1 M).
extended description :
Highly potent EGFR-kinase inhibitor
化学品名文本 :
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride
配方 :
C 16 H 14 ClN 3 O 2 .HCl
配方文本 :
C16H14ClN3O2.氯化氢
cas num :
170449-18-0
美元 :
229美元
产品细节 :
Highly potent EGFR-kinase inhibitor
别名 :
一类酪氨酸激酶抑制剂老化1478
储存 :
Desiccate at -20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
公司总部: 英国