产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
GW 5074
目录 :
1381/10
规格 :
10 mg (also 50 mg)
价格 :
242美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 8
参考文献
Kaiserman J, O Hara B, Garabian K, Lukacher A, Haley S, Atwood W. The Oxindole GW-5074 Inhibits JC Polyomavirus Infection and Spread by Antagonizing the MAPK-ERK Signaling Pathway. MBio. 2023;:e0358322 pubmed 出版商
Li C, Wood D, Huang J, Bhatia S. Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments. Lab Chip. 2013;13:1969-78 pubmed 出版商
Cooper O, Seo H, Andrabi S, Guardia Laguarta C, Graziotto J, Sundberg M, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med. 2012;4:141ra90 pubmed 出版商
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed 出版商
Schaertl S, Prime M, Wityak J, Dominguez C, Munoz Sanjuan I, Pacifici R, et al. A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen. 2010;15:478-87 pubmed 出版商
Kim S, Thanh Thuy T, Lee J, Ro J, Bae Y, Kong Y, et al. Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract. Exp Mol Med. 2009;41:277-87 pubmed 出版商
Magro F, Fraga S, Soares da Silva P. Signaling of short- and long-term regulation of intestinal epithelial type 1 Na+/H+ exchanger by interferon-gamma. Br J Pharmacol. 2005;145:93-103 pubmed
Magro F, Fraga S, Ribeiro T, Soares da Silva P. Intestinal Na+-K+-ATPase activity and molecular events downstream of interferon-gamma receptor stimulation. Br J Pharmacol. 2004;142:1281-92 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1381
SKU号 :
1381/10
产品名称 :
GW 5074
描述 :
Potent, selective c-Raf1 kinase inhibitor
靶标 :
Raf Kinase Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
520.94
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). GW 5074 displays 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW 5074 binds mutant huntingtin (mHTT) and decreases levels of mHTT in cultured hippocampal neurons and fibroblasts from patients with Huntington s disease. Brain penetrant.
extended description :
Potent, selective c-Raf1 kinase inhibitor
化学品名文本 :
3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one
配方 :
C 15 H 8 Br 2 INO 2
配方文本 :
C15H8Br2INO2
cas num :
220904-83-6
美元 :
242美元
产品细节 :
Potent, selective c-Raf1 kinase inhibitor
储存 :
Desiccate at -20°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国