PP 1 | Tocris Bioscience 1397/10 产品信息

产品简要

公司名称 :

Tocris Bioscience

产品类型 :

化学品

产品名称 :

PP 1

1397/10

规格 :

10毫克

价格 :

353美元

更多信息或购买 :

Tocris Bioscience 产品网页

文章摘录数: 13

参考文献
Kurz J, Barthelmes J, Blum L, Ulshöfer T, Wegner M, Ferreirós N, et al. Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes. Sci Rep. 2019;9:747 pubmed 出版商
Ferland D, Darios E, Neubig R, Sjögren B, Truong N, Torres R, et al. Chemerin-induced arterial contraction is Gi- and calcium-dependent. Vascul Pharmacol. 2017;88:30-41 pubmed 出版商
Mace E, Gunesch J, Dixon A, Orange J. Human NK cell development requires CD56-mediated motility and formation of the developmental synapse. Nat Commun. 2016;7:12171 pubmed 出版商
Lotz Jenne C, Lüthi U, Ackerknecht S, Lehembre F, Fink T, Stritt M, et al. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. Oncotarget. 2016;7:25983-6002 pubmed 出版商
Koutsioumpa M, Poimenidi E, Pantazaka E, Theodoropoulou C, Skoura A, Megalooikonomou V, et al. Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor. Mol Cancer. 2015;14:19 pubmed 出版商
Pham H, Chen M, Takahashi H, King J, Reber H, HINES O, et al. Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells. Pancreas. 2012;41:1306-15 pubmed 出版商
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed 出版商
Hildebrand M, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, et al. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci. 2009;29:9668-82 pubmed 出版商
Eum S, Andras I, Hennig B, Toborek M. NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells. Toxicol Appl Pharmacol. 2009;240:299-305 pubmed 出版商
Mikelis C, Sfaelou E, Koutsioumpa M, Kieffer N, Papadimitriou E. Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta. FASEB J. 2009;23:1459-69 pubmed 出版商
Alonso Magdalena P, Ropero A, Carrera M, Cederroth C, Baquie M, Gauthier B, et al. Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS ONE. 2008;3:e2069 pubmed 出版商
Lee Y, Kayyali U, Sousa A, Rajan T, Lechleider R, Day R. Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src. Am J Respir Cell Mol Biol. 2007;37:485-93 pubmed
Zhang J, Kalyankrishna S, Wislez M, Thilaganathan N, Saigal B, Wei W, et al. SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. Am J Pathol. 2007;170:366-76 pubmed

产品信息

品牌 :

Tocris, a Bio-Techne Brand

catalog number base :

1397

SKU号 :

1397/10

产品名称 :

PP 1

描述 :

Potent, selective Src family kinase inhibitor

靶标 :

Src Family Kinase Inhibitors

类别 :

Small Molecules

单位尺寸 :

10毫克

纯度 :

99%

观察到的分子量 :

281.36

网址印刷 :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

功能细节 :

PP 1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.

extended description :

Potent, selective Src family kinase inhibitor

化学品名文本 :

1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

配方 :

C 16 H 19 N 5

配方文本 :

C16H19N5

cas num :

172889-26-8

美元 :

353美元

产品细节 :

Potent, selective Src family kinase inhibitor

储存 :

Desiccate at +4°C

更多信息或购买 :

Tocris Bioscience 产品网页

公司信息

Tocris Bioscience

The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD

info@bio-techne.com

https://www.tocris.com

800-343-7475

公司总部: 英国