产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
PP 2
目录 :
1407/10
规格 :
10毫克
价格 :
358美元
更多信息或购买 :
文章摘录数: 51
参考文献
Dandoulaki M, Petsalaki E, Sumpton D, Zanivan S, Zachos G. Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis. J Cell Biol. 2018;217:3071-3089 pubmed 出版商
Poli G, Lapillo M, Granchi C, Caciolla J, Mouawad N, Caligiuri I, et al. Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors. J Enzyme Inhib Med Chem. 2018;33:956-961 pubmed 出版商
Li X, Chen W, Li P, Wei J, Cheng Y, Liu P, et al. Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression. Theranostics. 2017;7:4671-4688 pubmed 出版商
Hass H, Kipkeew F, Gauhar A, Bouché E, May P, Timmer J, et al. Mathematical model of early Reelin-induced Src family kinase-mediated signaling. PLoS ONE. 2017;12:e0186927 pubmed 出版商
Mittelman Smith M, Wong A, Micevych P. Estrogen and Progesterone Integration in an in vitro Model of RP3V Kisspeptin Neurons. Neuroendocrinology. 2018;106:101-115 pubmed 出版商
Walko G, Woodhouse S, Pisco A, Rognoni E, Liakath Ali K, Lichtenberger B, et al. A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells. Nat Commun. 2017;8:14744 pubmed 出版商
Zhu J, Li K, Cao S, Chen X, Shen C, Zhang Y, et al. Increased NRG1-ErbB4 signaling in human symptomatic epilepsy. Sci Rep. 2017;7:141 pubmed 出版商
Wang Y, Gratzke C, Tamalunas A, Rutz B, Ciotkowska A, Strittmatter F, et al. Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2. Br J Pharmacol. 2016;173:3342-3358 pubmed 出版商
Lotz Jenne C, Lüthi U, Ackerknecht S, Lehembre F, Fink T, Stritt M, et al. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. Oncotarget. 2016;7:25983-6002 pubmed 出版商
Berretta A, Gowing E, Jasoni C, Clarkson A. Sonic hedgehog stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis. Sci Rep. 2016;6:21896 pubmed 出版商
Delaney A, Crane J. Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep. 2016;6:19255 pubmed 出版商
Li X, Rhee D, Malhotra R, Mayeur C, Hurst L, Ager E, et al. Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest. 2016;126:389-401 pubmed 出版商
De Mario A, Castellani A, Peggion C, Massimino M, Lim D, Hill A, et al. The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase. Front Cell Neurosci. 2015;9:416 pubmed 出版商
Harazono Y, Kho D, Balan V, Nakajima K, Hogan V, Raz A. Extracellular galectin-3 programs multidrug resistance through Na+/K+-ATPase and P-glycoprotein signaling. Oncotarget. 2015;6:19592-604 pubmed
Rosas O, Torrado A, Santiago J, Rodríguez A, Salgado I, Miranda J. Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Neural Regen Res. 2014;9:2164-73 pubmed 出版商
Vijayakumar V, Monypenny J, Chen X, Machesky L, Lilla S, Thrasher A, et al. Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. J Cell Sci. 2015;128:251-65 pubmed 出版商
Di Angelantonio S, Murana E, Cocco S, Scala F, Bertollini C, Molinari M, et al. A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium. Cell Death Dis. 2014;5:e1501 pubmed 出版商
Kupferman J, Basu J, Russo M, Guevarra J, Cheung S, Siegelbaum S. Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment. Cell. 2014;158:1335-1347 pubmed 出版商
Kubota H, Nagao S, Obata K, Hirono M. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS ONE. 2014;9:e106316 pubmed 出版商
Cai Q, Yan L, Xu Y. Anoikis resistance is a critical feature of highly aggressive ovarian cancer cells. Oncogene. 2015;34:3315-24 pubmed 出版商
Moser R, Xu C, Kao M, Annis J, Lerma L, Schaupp C, et al. Functional kinomics identifies candidate therapeutic targets in head and neck cancer. Clin Cancer Res. 2014;20:4274-88 pubmed 出版商
Sato Y, Fujimoto S, Mukai E, Sato H, Tahara Y, Ogura K, et al. Palmitate induces reactive oxygen species production and ?-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling. J Diabetes Investig. 2014;5:19-26 pubmed 出版商
Chen W, Walwyn W, Ennes H, Kim H, McRoberts J, Marvizon J. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci. 2014;39:1439-54 pubmed 出版商
Wills M, Tong J, Tremblay S, Moran M, Jones N. The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor. Mol Biol Cell. 2014;25:739-52 pubmed 出版商
Bayliss A, Evans P. Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-dopamine-like G protein-coupled receptor. PLoS ONE. 2013;8:e80833 pubmed 出版商
Mitrugno A, Williams D, Kerrigan S, Moran N. A novel and essential role for Fc?RIIa in cancer cell-induced platelet activation. Blood. 2014;123:249-60 pubmed 出版商
Soltoff S, Lannon W. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells. PLoS ONE. 2013;8:e72881 pubmed 出版商
Joshi A, Dimitropoulou C, Thangjam G, Snead C, Feldman S, Barabutis N, et al. Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling. Am J Respir Cell Mol Biol. 2014;50:170-9 pubmed 出版商
van Vliet S, Vuist I, Lenos K, Tefsen B, Kalay H, Garcia Vallejo J, et al. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem. 2013;288:27519-32 pubmed 出版商
Mobasher M, Gonzalez Rodriguez A, Santamaria B, Ramos S, Martin M, Goya L, et al. Protein tyrosine phosphatase 1B modulates GSK3?/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity. Cell Death Dis. 2013;4:e626 pubmed 出版商
Cho I, Kim D, Lee M, Bae J, Lee K, Song W. SPIN90 phosphorylation modulates spine structure and synaptic function. PLoS ONE. 2013;8:e54276 pubmed 出版商
Leoni G, Alam A, Neumann P, Lambeth J, Cheng G, McCoy J, et al. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest. 2013;123:443-54 pubmed 出版商
Byun S, Park J, Lee E, Lim S, Yu J, Lee S, et al. Src kinase is a direct target of apigenin against UVB-induced skin inflammation. Carcinogenesis. 2013;34:397-405 pubmed 出版商
Pham H, Chen M, Takahashi H, King J, Reber H, HINES O, et al. Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells. Pancreas. 2012;41:1306-15 pubmed 出版商
Nebieridze N, Zhang X, Chachua T, VELISEK L, Stanton P, VELISKOVA J. ?-Estradiol unmasks metabotropic receptor-mediated metaplasticity of NMDA receptor transmission in the female rat dentate gyrus. Psychoneuroendocrinology. 2012;37:1845-54 pubmed 出版商
Bigford G, Chaudhry N, Keane R, Holohean A. 5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization. J Biol Chem. 2012;287:11049-59 pubmed 出版商
Zhou L, Too H. Mitochondrial localized STAT3 is involved in NGF induced neurite outgrowth. PLoS ONE. 2011;6:e21680 pubmed 出版商
Zhang D, Wu W, Deng X, Lau C, Li G. Genistein and tyrphostin AG556 inhibit inwardly-rectifying Kir2.1 channels expressed in HEK 293 cells via protein tyrosine kinase inhibition. Biochim Biophys Acta. 2011;1808:1993-9 pubmed 出版商
Zhang D, Zhang Y, Sun H, Lau C, Li G. Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium K(IR)2.3 channel, stably expressed in HEK 293 cells. Br J Pharmacol. 2011;164:1469-78 pubmed 出版商
Ivanova M, Luken K, Zimmer A, Lenzo F, Smith R, Arteel M, et al. Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites. FASEB J. 2011;25:1402-16 pubmed 出版商
Töyli M, Rosberg Kulha L, Capra J, Vuoristo J, Eskelinen S. Different responses in transformation of MDCK cells in 2D and 3D culture by v-Src as revealed by microarray techniques, RT-PCR and functional assays. Lab Invest. 2010;90:915-28 pubmed 出版商
Dong M, Sun H, Tang Q, Tse H, Lau C, Li G. Regulation of human cardiac KCNQ1/KCNE1 channel by epidermal growth factor receptor kinase. Biochim Biophys Acta. 2010;1798:995-1001 pubmed 出版商
Deuretzbacher A, Czymmeck N, Reimer R, Tr lzsch K, Gaus K, Hohenberg H, et al. Beta1 integrin-dependent engulfment of Yersinia enterocolitica by macrophages is coupled to the activation of autophagy and suppressed by type III protein secretion. J Immunol. 2009;183:5847-60 pubmed 出版商
Hildebrand M, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, et al. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci. 2009;29:9668-82 pubmed 出版商
Grodzki A, Moon K, Berenstein E, Siraganian R. FcepsilonRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation. Mol Immunol. 2009;46:2539-47 pubmed 出版商
Melis M, Pillolla G, Luchicchi A, Muntoni A, Yasar S, Goldberg S, et al. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. J Neurosci. 2008;28:13985-94 pubmed 出版商
Stramiello M, Wagner J. D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. Neuropharmacology. 2008;55:871-7 pubmed 出版商
Scheiderer C, Smith C, McCutchen E, MCCOY P, Thacker E, Kolasa K, et al. Coactivation of M(1) muscarinic and alpha1 adrenergic receptors stimulates extracellular signal-regulated protein kinase and induces long-term depression at CA3-CA1 synapses in rat hippocampus. J Neurosci. 2008;28:5350-8 pubmed 出版商
Gonzalez Maeso J, Weisstaub N, Zhou M, Chan P, Ivic L, Ang R, et al. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron. 2007;53:439-52 pubmed
Belcher S, Le H, Spurling L, Wong J. Rapid estrogenic regulation of extracellular signal- regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A. Endocrinology. 2005;146:5397-406 pubmed
Du X, Gao Z, Lau C, Chiu S, Tse H, Baumgarten C, et al. Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases. J Gen Physiol. 2004;123:427-39 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1407
SKU号 :
1407/10
产品名称 :
PP 2
描述 :
Potent, selective Src family kinase inhibitor
靶标 :
Src Family Kinase Inhibitors
类别 :
Small Molecules
单位尺寸 :
10毫克
纯度 :
99%
观察到的分子量 :
301.78
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
PP 2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 M). . Negative Control also available.
extended description :
Potent, selective Src family kinase inhibitor
化学品名文本 :
3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
配方 :
C 15 H 16 ClN 5
配方文本 :
C15H16ClN5
cas num :
172889-27-9
美元 :
358美元
产品细节 :
Potent, selective Src family kinase inhibitor
储存 :
Desiccate at +4°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国