产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
1400W dihydrochloride
目录 :
1415/10
规格 :
10 mg (also 50 mg)
价格 :
150美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 9
参考文献
Müller E, Speth M, Christopoulos P, Lunde A, Avdagic A, Øynebråten I, et al. Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation. Front Immunol. 2018;9:2520 pubmed 出版商
Staunton C, Barrett Jolley R, Djouhri L, Thippeswamy T. Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model. Exp Physiol. 2018;103:535-544 pubmed 出版商
Kuen J, Darowski D, Kluge T, Majety M. Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model. PLoS ONE. 2017;12:e0182039 pubmed 出版商
Clark A, Gruber Schoffnegger D, Drdla Schutting R, Gerhold K, Malcangio M, Sandkühler J. Selective activation of microglia facilitates synaptic strength. J Neurosci. 2015;35:4552-70 pubmed 出版商
Gross G, Hsu A, Pfeiffer A, Nithipatikom K. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol. 2013;59:20-9 pubmed 出版商
Gresa Arribas N, Viéitez C, Dentesano G, Serratosa J, Saura J, Solà C. Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents. PLoS ONE. 2012;7:e45227 pubmed 出版商
Al Shalmani S, Suri S, Hughes D, Kroon P, Needs P, Taylor M, et al. Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery. Br J Pharmacol. 2011;162:1485-97 pubmed 出版商
Tsuda M, Toyomitsu E, Kometani M, Tozaki Saitoh H, Inoue K. Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways. J Cell Mol Med. 2009;13:3251-9 pubmed 出版商
Ashrafpour H, Huang N, Neligan P, Forrest C, Addison P, Moses M, et al. Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature. Am J Physiol Heart Circ Physiol. 2004;286:H946-54 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1415
SKU号 :
1415/10
产品名称 :
1400W dihydrochloride
描述 :
Potent, highly selective iNOS inhibitor
靶标 :
iNOS Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
250.17
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
1400W dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 u M respectively). Cell-permeable and active in vivo . Neuroprotective in epilepsy models and has analgesic effects in models of mechanical and heat hypersensitivity.
extended description :
Potent, highly selective iNOS inhibitor
化学品名文本 :
N-[[3-(Aminomethyl)phenyl]methyl]-ethanimidamide dihydrochloride
配方 :
C 10 H 15 N 3。 2HCl
配方文本 :
C10H15N3.2HCl
cas num :
214358-33-5
美元 :
150美元
产品细节 :
Potent, highly selective iNOS inhibitor
储存 :
Desiccate at RT
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国