产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
GR 127935 hydrochloride
目录 :
1477/10
规格 :
10 mg (also 50 mg)
价格 :
264美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 8
参考文献
Li Y, Lucas Osma A, Black S, Bandet M, Stephens M, Vavrek R, et al. Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nat Med. 2017;23:733-741 pubmed 出版商
Akerman S, Holland P, Lasalandra M, Goadsby P. Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and "triptan" receptors: implications in migraine. J Neurosci. 2013;33:14869-77 pubmed 出版商
Khatri N, Simpson K, Lin R, Paul I. Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders. Psychopharmacology (Berl). 2014;231:1191-200 pubmed 出版商
Eriksson T, Alvarsson A, Stan T, Zhang X, Hascup K, Hascup E, et al. Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Mol Psychiatry. 2013;18:1096-105 pubmed 出版商
Baillie L, Ahn A, Mulligan S. Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. Neuropharmacology. 2012;63:362-7 pubmed 出版商
Masterson C, Durham P. DHE repression of ATP-mediated sensitization of trigeminal ganglion neurons. Headache. 2010;50:1424-39 pubmed 出版商
Wei L, Liu Y, Kaneto H, Fanburg B. JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2010;298:L863-9 pubmed 出版商
Morikawa T, Matsuzawa Y, Makita K, Katayama Y. Antimigraine drug, zolmitriptan, inhibits high-voltage activated calcium currents in a population of acutely dissociated rat trigeminal sensory neurons. Mol Pain. 2006;2:10 pubmed
产品信息
品牌 :
Tocris
MasterCode :
1477
SKU号 :
1477/10
产品名称 :
GR 127935 hydrochloride
靶标 :
5-HT1D Receptor Antagonists
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
534.06
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
GR 127935 hydrochloride is a potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration.
extended description :
Potent and selective 5-HT1B and 5-HT1D antagonist
化学品名文本 :
N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2 -methyl-4 -(5-methyl-1,2,4-oxadiazol-3-yl)-1,1 -biphenyl-4-carboxamide hydrochloride
配方 :
C 29 H 31 N 5 O 3。 氯化氢
配方文本 :
C29H31N5O3.氯化氢
cas num :
148642-42-6
美元 :
264美元
产品细节 :
Potent and selective 5-HT1B and 5-HT1D antagonist
储存 :
Desiccate at RT
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国