产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
GW 9662
目录 :
1508/10
规格 :
10 mg (also 50 mg)
价格 :
202美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 13
参考文献
Smith D, Martinelli R, Besra G, Illarionov P, Szatmari I, Brazda P, et al. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology (Berl). 2019;: pubmed 出版商
Guo B, Huang X, Lee M, Lee S, Broxmeyer H. Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nat Med. 2018;24:360-367 pubmed 出版商
Helmy M, Helmy M, El Mas M. Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs. PLoS ONE. 2015;10:e0142303 pubmed 出版商
Kotla S, Rao G. Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation. J Biol Chem. 2015;290:30306-20 pubmed 出版商
Chen T, Shih C, Hsu W, Chou T. Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets. PLoS ONE. 2015;10:e0127054 pubmed 出版商
Shih C, Lin I, Ding J, Chen F, Chou T. Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity. Br J Pharmacol. 2014;171:1490-1500 pubmed 出版商
Ramachandran L, Manu K, Shanmugam M, Li F, Siveen K, Vali S, et al. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor ? activation pathway in gastric cancer. J Biol Chem. 2012;287:38028-40 pubmed 出版商
Mottillo E, Bloch A, Leff T, Granneman J. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply. J Biol Chem. 2012;287:25038-48 pubmed 出版商
Scuderi C, Valenza M, Stecca C, Esposito G, Carratu M, Steardo L. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-?. J Neuroinflammation. 2012;9:49 pubmed 出版商
Esposito G, Scuderi C, Valenza M, Togna G, Latina V, De Filippis D, et al. Cannabidiol reduces A?-induced neuroinflammation and promotes hippocampal neurogenesis through PPAR? involvement. PLoS ONE. 2011;6:e28668 pubmed 出版商
Ali F, Armstrong P, Dhanji A, Tucker A, Paul Clark M, Mitchell J, et al. Antiplatelet actions of statins and fibrates are mediated by PPARs. Arterioscler Thromb Vasc Biol. 2009;29:706-11 pubmed 出版商
Postea O, Koenen R, Hristov M, Weber C, Ludwig A. Homocysteine up-regulates vascular transmembrane chemokine CXCL16 and induces CXCR6+ lymphocyte recruitment in vitro and in vivo. J Cell Mol Med. 2008;12:1700-9 pubmed 出版商
Ali F, Davidson S, Moraes L, Traves S, Paul Clark M, Bishop Bailey D, et al. Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARbeta. FASEB J. 2006;20:326-8 pubmed
产品信息
品牌 :
Tocris
MasterCode :
1508
SKU号 :
1508/10
产品名称 :
GW 9662
靶标 :
PPAR gamma Receptor Antagonists
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
276.68
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
GW 9662 is a selective irreversible PPAR antagonist (IC50 values are 3.3, 32 and 2000 nM for PPAR , PPAR and PPAR respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 u M), therefore is more potent than BADGE. Anticancer, inhibits growth of human mammary tumor cell lines.
extended description :
Selective covalent PPAR antagonist
化学品名文本 :
2-Chloro-5-nitro-N-phenylbenzamide
配方 :
C 13 H 9 N 2 O 3 Cl
配方文本 :
C13H9N2O3Cl
cas num :
22978-25-2
美元 :
202美元
产品细节 :
Selective covalent PPAR antagonist
储存 :
存放在RT
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国