产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
老化825
目录 :
1555/10
规格 :
10 mg (also 50 mg)
价格 :
189美元
更多信息或购买 :
文章摘录数: 5
参考文献
Wu L, Ramirez S, Andrews A, Leung W, Itoh K, Wu J, et al. Neuregulin1-β decreases interleukin-1β-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability. J Neurochem. 2016;136:250-7 pubmed 出版商
Lee C, Lin Y, Bratman S, Feng W, Kuo A, Scheeren F, et al. Neuregulin autocrine signaling promotes self-renewal of breast tumor-initiating cells by triggering HER2/HER3 activation. Cancer Res. 2014;74:341-52 pubmed 出版商
Akhtar S, Yousif M, Dhaunsi G, Sarkhouh F, Chandrasekhar B, Attur S, et al. Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction. PLoS ONE. 2013;8:e67813 pubmed 出版商
Lucchetti C, Caligiuri I, Toffoli G, Giordano A, Rizzolio F. The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor ? in breast cancer. PLoS ONE. 2013;8:e55355 pubmed 出版商
Kedrin D, Wyckoff J, Boimel P, Coniglio S, Hynes N, Arteaga C, et al. ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation. Clin Cancer Res. 2009;15:3733-9 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
1555
SKU号 :
1555/10
产品名称 :
老化825
靶标 :
EGF Receptor Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
观察到的分子量 :
397.47
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
AG 825 is a selective ErbB2 inhibitor (IC50 values are 0.15 and 19 M at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.
extended description :
Selective ErbB2 inhibitor
化学品名文本 :
3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide
配方 :
C 19 H 15 N 3 O 3秒2
配方文本 :
C19H15N3O3S2
cas num :
149092-50-2
美元 :
189美元
产品细节 :
Selective ErbB2 inhibitor
别名 :
一类酪氨酸激酶抑制剂老化825
储存 :
存放在+4°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国