Purvalanol A | Tocris Bioscience 1580/10 产品信息

产品简要

公司名称 :

Tocris Bioscience

产品类型 :

化学品

产品名称 :

Purvalanol A

1580/10

规格 :

10 mg (also 50 mg)

价格 :

252美元

更多信息或购买 :

Tocris Bioscience 产品网页

文章摘录数: 8

参考文献
Karayel Ö, Sanal E, Giese S, Üretmen Kagıalı Z, Polat A, Hu C, et al. Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis. Sci Rep. 2018;8:2269 pubmed 出版商
Gayek A, Ohi R. CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis. PLoS ONE. 2016;11:e0157491 pubmed 出版商
Seldin L, Poulson N, Foote H, Lechler T. NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. Mol Biol Cell. 2013;24:3651-62 pubmed 出版商
Origanti S, Cai S, Munir A, White L, Piwnica Worms H. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene. 2013;32:577-88 pubmed 出版商
Fabritius A, Flynn J, McNally F. Initial diameter of the polar body contractile ring is minimized by the centralspindlin complex. Dev Biol. 2011;359:137-148 pubmed 出版商
Rowe J, Greenblatt R, Liu D, Moffat J. Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice. Antiviral Res. 2010;86:276-85 pubmed 出版商
Ozlu N, Monigatti F, Renard B, Field C, Steen H, Mitchison T, et al. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics. 2010;9:336-50 pubmed 出版商
Pennati M, Campbell A, Curto M, Binda M, Cheng Y, Wang L, et al. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005;4:1328-37 pubmed

产品信息

品牌 :

Tocris

MasterCode :

1580

SKU号 :

1580/10

产品名称 :

Purvalanol A

靶标 :

Cyclin-dependent Kinase Inhibitors

类别 :

Small Molecules

单位尺寸 :

10 mg (also 50 mg)

纯度 :

98%

观察到的分子量 :

388.9

网址印刷 :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

功能细节 :

Purvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 4, 4 - 70, 75 - 240 and 100 nM for cdk1, cdk2, cdk5 and cdk 7, respectively). Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

extended description :

Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

化学品名文本 :

(2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

配方 :

C 19 H 25 ClN 6 O

配方文本 :

C19H25ClN6O

cas num :

212844-53-6

美元 :

252美元

产品细节 :

Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

别名 :

NG 60

储存 :

存放在+4°C

更多信息或购买 :

Tocris Bioscience 产品网页

公司信息

Tocris Bioscience

The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD

info@bio-techne.com

https://www.tocris.com

800-343-7475

公司总部: 英国